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99,167 grants found
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Role of Hypothalamic Adgrl1 in Counteracting Hypoglycemia
The hypothalamus is a hub for counteracting dangerously low blood glucose levels by stimulating the counterregulatory response (CRR) to subsequently restore normal blood glucose le...
Provider and Survivor Perspectives on Screening for Intimate Partner Violence During Pregnancy and Postpartum
PROJECT ABSTRACT Homicide is a leading cause of death among women who are pregnant and within 1-year postpartum in the US. A majority of cases involve intimate partner violence (IP...
Adeno-associated virus-mediated SGPL1 gene therapy as a first-in-class treatment for idiopathic pulmonary fibrosis that acts by reducing sphingosine-1-phosphate and downstream profibrotic signaling
Summary Idiopathic pulmonary fibrosis (IPF) is a severe age-related lung disease that affects millions of people worldwide. It causes progressive lung dysfunction leading to death,...
Mechanisms of ciliopathy associated structural birth defects
PROJECT SUMMARY/ABSTRACT Cilia are complex structures with more than 1,300 proteins involved in their formation and function. During development, disruption of cilia function cause...
SUNBEAM Birth Cohort: Deciphering the role of early life skin dysfunction in development of the allergic march
PROJECT SUMMARY/ABSTRACT Allergic diseases, including atopic dermatitis (AD), food allergies (FA), and asthma are common in young children and are often co-morbid, suggesting a sha...
Role of ERK1/2 signaling in SARS-CoV-2 -induced dysregulated immunity and lung pathology.
Project Summary (Abstract): Emerging and re-emerging respiratory viruses such as SARS-CoV, MERS-CoV, SARS-CoV-2, and avian and swine influenza viruses continue to pose a significan...
Developing Human Pluripotent Stem Cell Tools for Region-Specific Pain Circuits
PROJECT SUMMARY/ABSTRACT Species-specific differences and the complexity of cellular interactions involved in human pain perception have created challenges relying on conventional...
Genetic editing and cell therapy for correction of CLCN7 mutations in osteopetrosis
Project Summary: Osteopetrosis is a heritable skeletal disorder characterized by abnormal systemic increase in bone mass density, bone marrow failure, bone fractures, osteomyelitis...
Social Determinants of Adolescent and Young Adult Mortality: New Evidence from Large-Scale Administrative Data
Concerns about deteriorating mental health, substance use disorders, early development of chronic conditions, exposure to economic shocks, and to violence---causes that may all lea...
Investigation of blood fitness genes in the tsetse fly symbiont Sodalis glossinidius
Project summary/abstract: Tsetse flies (Genus: Glossina) are cyclic vectors of protozoan African trypanosomes (Trypanosoma sp.), the causative agents of human and animal African tr...
Pathways regulating profibrotic macrophages in a novel explant model of systemic sclerosis-associated interstitial lung disease
Systemic sclerosis (SSc) is a complex disease involving multiple cell types, leading to a plethora of clinical manifestations. SSc-associated interstitial lung disease (SSc-ILD) is...
Electrified cryo-EM: a new tool to capture metastable neuron structures during an action potential
Project Summary:There remains a critical blind spot in the study of biological systems. In situ imaging techniques like super-resolution microscopy can elucidate cellular dynamics...
Exploring cortical inhibitory circuit design in the human brain
PROJECT SUMMARY A basic understanding of human neural circuit design is essential to grasping neurological disease processes and developing targeted brain therapies. However, due t...
Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN)
OVERALL – ABSTRACT Chicago, one of the most diverse yet segregated cities in the US, is characterized by egregious cancer health inequities. We propose to establish the Advancing C...
Administrative Core
ADMINISTRATIVE CORE – ABSTRACT To support the mission of the Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN) Center as a...
Research Methods, Measures, and Data Management Core
RESEARCH METHODS, MEASURES AND DATA MANAGEMENT CORE – ABSTRACT The Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation Center (ACCERT PN...
Advancing Innovations in Patient Navigation and Implementation Science to Address Structural Racism and Social Determinants of Health
SOCIAL DETERMINANTS OF HEALTH RESEARCH PROJECT – ABSTRACT Cancer is a leading cause of death in Chicago, and Black, Latinx and low-income Chinese communities in Chicago face signif...
Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation - Community Responsive Projects
COMMUNITY RESPONSIVE PROJECTS – ABSTRACT Community Responsive Projects within the Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (A...
Brain Metabolites and Temperature Changes in Obstructive Sleep Apnea Adults
PROJECT SUMMARY/ ABSTRACT Obstructive sleep apnea (OSA), a life-threatening condition, affects ~10% adults in the United States. The condition is accompanied by multiple symptoms (...
Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health
PROJECT SUMMARY Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however, we do not understand their long-term health effects. Although ENDS use deliv...