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99,167 grants found
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Social media support groups for adolescent vaping cessation
ABSTRACT Tobacco use causes one third of cancer-related mortality. Decades of tobacco control progress are threatened by the promotion and popularity of e-cigarettes (colloquially...
Promoting algorithmic equity in in-hospital mortality prediction
Project Summary/Abstract In-hospital mortality prediction models (MPMs) are widely used in clinical research and practice; but existing MPMs suffer from algorithmic bias, or system...
TLR Agonist Nano-Immune Therapy for Peritoneal Metastases
Summary Peritoneal metastases are present at diagnosis in 57% of women with ovarian cancer and 8% of patients with colorectal cancer. Peritoneal metastases have been considered a t...
Neuron vasculature interactions in pain
Neuropathic spontaneous pain, a main symptom of neuropathic pain, is often a particularly intractable clinical problem. While much has been done to understand the sensory sensitiza...
Next Generation Immunotherapies for Pediatric Cancers
PROJECT SUMMARY Since the 1990s, pediatric oncology has made sustained strides in understanding the biology that drives children’s cancers, but these understandings have not yielde...
APOL1 as a model to quantify and identify environmental modifiers of genetic associations in diverse populations
PROJECT SUMMARY Complex human traits and outcomes have substantial genetic and environmental contributions that, when identified, lead to a better understanding of underlying biolo...
Peptide Nucleic Acid (PNA) Oligomers for Targeted Disruption of Biomolecular Condensates in ALS/FTD
PROJECT SUMMARY The formation of biomolecular condensates (BMCs) is an important phenomenon in biology, creating transient compartments that can accelerate biochemical reactions or...
TB PrEP - Integrating HIV prevention with TB household contact evaluation
ABSTRACT HIV and TB are leading and linked global epidemics. Household members of people with TB have an elevated prevalence and incidence of both TB and HIV. HIV pre-exposure prop...
SCH: Smart Breath- based Diagnosis of Pulmonary Exacerbations in Children with Cystic Fibrosis through Machine Learning: Towards Noninvasive Health Monitoring in Real-Time
Cystic fibrosis (CF) is a genetic disorder that negatively affects young people across the globe. Pulmonary exacerbations (PEx), episodes of decreased lung function accompanied by...
Fabrication of solid and long-lasting phantoms for calibrating parametric OCT imaging
Project Summary Optical coherence tomography (OCT) has revolutionized medical diagnostics by providing high- resolution morphological imaging. However, the early stages of many dis...
Early podocyte injury in collagen IV nephropathy
for R-56 related to 1R01DK139111-0The goal of this project, “Early podocyte injury in collagen IV nephropathy”, is to understand the earliest events in podocyte injury in Collagen...
Long-term alteration of the airway epithelium after early life RSV infection
Severe RSV-bronchiolitis infection has been associated with the development of asthma later in childhood. RSV is the primary cause of bronchiolitis in children worldwide, and it is...
Structure and Biology of Tissue Factor Pathway Inhibitor-2
Project Summary Tissue factor pathway inhibitor-2 (TFPI-2) consists of three Kunitz domains arranged in tandem flanked by a short acidic amino terminus and a highly basic C-termina...
Rat model for investigating NK cells at the uterine-placental interface
PROJECT SUMMARY/ABSTRACT The placenta plays a crucial role during pregnancy ensuring fetal growth and development. Successful pregnancy hinges upon placental adaptations to the mat...
Quantitative super-resolution imaging to map the multi-scale functional organization of cells
Project Summary The long-term goal of this proposal is to understand the mechanisms that regulate sub-cellular organization and the significance of this organization to organelle a...
Cortical Interneuron Transplantation to Treat Intractable Epilepsy
Abstract Epilepsy is a severe neurological disease affecting more than 65 million people worldwide and is characterized by unpredictable abnormal electrical discharges resulting in...
Functional Validation of Novel Variants Associated with Congenital Diaphragmatic Hernia
PROJECT SUMMARY/ABSTRACT Congenital Diaphragmatic Hernia (CDH) is a common and severe structural birth defect arising in 1 out of 3000 live births, accounting for 8% of all congeni...
2/2 Large-scale, single-cell characterization of molecular and cellular networks of mood regulation circuitry in major depressive disorder
While there is strong evidence supporting the role of the anterior cingulate cortex, basolateral amygdala, and the hippocampus (ACC, BLA, HIPP) as a key neural network regulating m...
1/2 Large-scale, single-cell characterization of molecular and cellular networks of mood regulation circuitry in major depressive disorder
While there is strong evidence supporting the role of the anterior cingulate cortex, basolateral amygdala, and the hippocampus (ACC, BLA, HIPP) as a key neural network regulating m...
Development of stretchable optical sensors for measurement of penile hemodynamics
Project Summary/Abstract Erectile dysfunction (ED) is a progressive disease, which is often characterized by rampant fibrosis of the corpus cavernosum in severe disease states. It...