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99,167 grants found
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In vivo hematopoietic stem cell genetic modification by viral particles
PROJECT SUMMARY Hematopoietic stem cell (HSC) gene therapies with lentiviral or CRISPR based gene modification are demonstrating favorable safety profiles and remarkable efficacy t...
Hybrid Type-1 Effectiveness-Implementation Trial of Motivation Matters! A Theory-Based mHealth Intervention to Support Early Antiretroviral Adherence in HIV+ African Women Who Engage in Sex Work
The United Nations Joint Programme on HIV/AIDS describes current global HIV data as frightening. In the landmark year 2020, all global targets for HIV treatment and prevention were...
Artificial intelligence-integrated mechanistic modeling for rational design of nanoparticles to improve organ targeting and safety
PROJECT SUMMARY. Nanoparticles (NPs) hold great promise as targeted drug delivery systems but tailoring their pharmacokinetics (PK) to specifically target regions of interest remai...
Subjective and Somatic Tinnitus; Using Functional Near-Infrared-Spectroscopy to Identify Objective Correlates in Auditory and Non-Auditory Cortices
Abstract: Phantom sound perception (tinnitus) arises from aberrant central auditory pathways. Subjective tinnitus is typically caused by hearing loss. Auditory cortex (AC) in tinni...
Targeting minimal residual disease in AML by using single-cell morphological and biophysical analysis with deep learning
Summary Conventional chemotherapy regimens induce complete remission in the majority of patients with acute myeloid leukemia (AML) and results in >95% reduction in tumor burden....
Translational genetic analysis in human and mouse GWAS to identify the genomic architecture of alcohol sensitivity and tolerance
ABSTRACT Alcohol use disorder (AUD) is a major U.S. health problem with 12-month and lifetime prevalence being 13.9% and 29.1%, respectively. AUD is partly caused by genetic factor...
Dual-targeted DOTA CAR T cells with image-guided monitoring for solid tumor treatment
Abstract CAR T cells can mediate deep, durable cancer remissions but their activity is not controllable once infused, they are not easily tracked, their risk for toxicity remains a...
Blockade of S1P pathway for renal fibrosis therapy
PROJECT ABSTRACT Chronic kidney disease (CKD), characterized by chronic inflammation and progressive fibrosis, is prevalent and can eventually lead to end-stage renal disease (ESRD...
Minimally Invasive and Versatile Next-Generation Implantable Medical Devices: A Leap Towards Precision Therapies and Medicine
PROJECT SUMMARY Implantable Medical Devices (IMDs) stand on the brink of a healthcare revolution, providing an unprecedented means of managing and preventing a myriad of diseases....
Programming cellular behavior by mechanical forces
ABSTRACT Cellular behaviors are modulated by a variety of stimuli in the environment, which can be generally categorized as chemical, physical, and biological factors. Previous wor...
Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)
PROJECT SUMMARY – OVERALL Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a rising cause of cancer mortality. HCC related to metabolic stress is on the r...
Core A: Administrative Core
PROJECT SUMMARY – CORE A: ADMINISTRATIVE The Administrative Core A, directed by Dr. Kaufman is an essential component of this Program Project, providing logistic and strategic supp...
Project 1: Control of NASH to HCC progression by the NRF2-FBP1 tug-of-war
PROJECT SUMMARY – PROJECT 1 Project 1 is striving to understand the role of transcription factor NRF2 and the gluconeogenic enzyme fructose bisphosphate phosphatase 1 (FBP1) in NAS...
Project 2: The UPR transducer ATF6 drives HCC in response to metabolic stress
PROJECT SUMMARY -PROJECT 2 Hepatocellular carcinoma is (HCC) is the most common primary liver cancer and 3rd leading cause of cancer deaths worldwide. HCC etiology is rapidly chang...
Project 3: Metabolic stress induces mitochondrial dysfunction through STARD1 and SAB leading to HCC
PROJECT SUMMARY – PROJECT 3 The incidence of NASH-driven HCC is expected to increase worldwide due to its association with the obesity and type-2 diabetes epidemic. Chronic ER stre...
Core 1: Metabolomics
PROJECT SUMMARY – CORE 1 The liver is of central importance to whole-body metabolism, with major roles, among others, in glucose and fatty acid metabolism, and cholesterol and bile...
Core 2: Bioinformatics/Biostatistics/Genomics
CORE 2 PROJECT SUMMARY Key to this proposal is the inclusion of Core 2, which encompasses unified support for Bioinformatics, Biostatistics, Genomics, Transcriptomics, and Computat...
Addressing Collagen Mediated Protection of Systemic Amyloid Fibrils
Project Abstract The systemic amyloidoses are a family of non-cerebral, protein misfolding disorders in which amyloidogenic precursor proteins aggregate into well-ordered amyloid f...
Evaluation of Commercial Mammography-Based Artificial Intelligence Algorithms for Breast Cancer Risk Prediction in U.S. Screening Populations
PROJECT SUMMARY Women known to be at high risk for breast cancer have opportunities to reduce their risk through primary and secondary breast cancer prevention, including risk-redu...
Conmigo: a multi-level mother-daughter physical activity intervention for pre-adolescent Latinas
ABSTRACT Fewer US Latina girls meet current physical activity (PA) guidelines, with lower rates observed among those from lower-income and less-acculturated backgrounds, contributi...