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99,167 grants found
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Center for Neurovascular Engineering Research and adVanced Education (NERVE)
Abstract The imperative for biomedical engineering research and education is underscored by the widespread prevalence of braindiseases and disorders, such as Alzheimer's disea...
Defining cellular and molecular processes underlying adipose tissue dysfunction onINSTI-based antiretroviral therapy
PROJECT SUMMARY/ABSTRACT The introduction of the integrase strand transfer inhibitor (INSTI) class of HIV drugs transformed the treatment of persons with HIV (PWH), offering highly...
Impacts of Telehealth Policies on Inequities in Perinatal Behavioral Health Care Access and Outcomes
Project Abstract: Suicide is now the leading cause of death during the perinatal period, and nearly a quarter of maternal deaths are attributable to behavioral health (BH) conditio...
Engineered bacterial in situ vaccines against oral cancer.
PROJECT SUMMARY. Immunotherapy has become an emerging standard-of-care (SOC) for many different cancer types. However, only 15-20% of patients receive durable benefit. Other limita...
DMS/NIGMS 1: Disease gene discovery by Markovian gene network
PROJECT SUMMARY (See instructions): In this proposal, we develop new interpretable statistical methodology to advance medical genetic, which seeks to understand the genetic basis o...
Genomic and Developmental Mechanisms of SIX2-Related Frontonasal Dysplasia
Abstract On average, a human genome harbors ~27,000 structural variations (SVs), including deletions, duplications, and other genomic changes over 50 bp in size, which contribute s...
Online and offline multiverse spillover: Mapping the ecology of youth mental health
Abstract Rates of mental and behavioral health disorders are increasing among adolescents coinciding with in- creases in overall time spent engaging with social media and other onl...
The Role of Medically Tailored Groceries in Mitigating Food Insecurity and Improving Pregnancy Outcomes through Clinic-Community Partnerships
ABSTRACT Medically tailored groceries (MTG) generally involve fresh and shelf-stable grocery items to be prepared at home, selected by a nutritional professional based on a treatme...
Bridge to Better End-of-Life Care for Black Patients with Cancer: Connecting Healthcare Chaplains with Spiritual Care Providers in Faith Communities
Project Summary Black patients with advanced cancer who receive cancer care in outpatient settings have unmet spiritual needs, receive care isolated from their faith communities, a...
Using Technology, Data, and Collaboration to Expand SLTT Conformance With the Voluntary National Retail Food Regulatory Program Standards
PROJECT SUMMARY After decades of incremental changes to the food safety system, technological advancements have ushered in a corresponding period of increased change for both food...
Harnessing a Two-State FEP LHS to Optimize Engagement and Prevent Disengagement in CSC
Overall Component - Abstract This Program Project Grant entitled Harnessing a Two-State FEP LHS to Optimize Engagement and Prevent Disengagement in CSC will leverage Connection Lea...
Alabama Dept. Of Agriculture & Industries AFRPS YR 24
Funding Opportunity – RFA-FD-24-035: Development and Maintenance of the Animal Feed Regulatory Program Standards Applicant: State of Alabama, Department of Agriculture and Industri...
Functional maturation of amygdala circuitry during adolescence
PROJECT SUMMARY/ABSTRACT The transition from adolescence to adulthood is a critical period of development characterized by significant changes in social-emotional behavior. One of...
SoS: BIO: Evaluating the Impact of Biomedical Tools and Methods
PROJECT SUMMARY (See instructions): Advances in biomedical sciences are often driven by new tools, ranging from novel experimental techniques, to innovative models, and new softwar...
Avoidance learning and pain circuit dysfunction in alcohol use disorders
PROJECT SUMMARY / ABSTRACT Alcohol use disorder (AUD) is a chronic debilitating condition that accounts for over half of all substance abuse treatment cases in the United States. M...
Defining how cellular DNA replication and repair machinery are hijacked by viral pathogens
PROJECT SUMMARY / ABSTRACT Mammals have evolved an extensive nuclear network of DNA replication and repair proteins that are tasked with amplifying and maintaining the fidelity of...
Dissecting the Impact of Viral Biomolecular Condensates on Cellular Translation and RNA Interference (RNAi)
PROJECT SUMMARY Biomolecular condensates are dynamic, membrane-less organelles formed within cells, and both host cells and viruses encode proteins that can assemble into these str...
Next-generation design of acoustic reporter genes with optimal assembly
Project Summary / Abstract The ability to visualize specific gene expression, exemplified by methods like green fluorescent protein (GFP) reporters, has been pivotal in scientific...
Functional Roles of Human Cytochrome P450 Enzymes
SUMMARY/ABSTRACT Cytochrome P450 (P450) enzymes are involved in the oxidations of ~95% of chemicals, including many drugs, steroids, and chemical carcinogens. The practical applica...
The Role of Brain-Bone Marrow-Gut Interaction following Major Trauma
ABSTRACT Trauma remains the leading cause of death among people younger than 46-years of age and is the leading cause of years of potential life lost among those younger than 65. W...