Browse All Grants
99,167 grants found
Showing 1,241 – 1,260 of 99,167 grants
Autism in Preterm Birth
PROJECT SUMMARY Autism Spectrum Disorder (ASD) risk is primarily of genetic origins with an estimated heritability of 80% but non-heritable factors are also important in understand...
Characterizing the natural history of sphingosine phosphate lyase insufficiency syndrome (SPLIS): a fundamental step in the development of a targeted cure for this novel atypical sphingolipidosis
Summary Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is an ultra-rare, devastating, often lethal inborn error of metabolism recognized just five years ago. Most aff...
Regulatory Mechanisms of PP2A Family Phosphatases
The overall goal of our research program is to gain a comprehensive understanding of the molecular mechanisms underlying the regulation of protein phosphatase 2A (PP2A) family phos...
Identifying new immunotherapeutic targets for endocrine autoimmunity.
PROJECT SUMMARY / ABSTRACT (OVERALL) Autoimmune endocrinopathies include a number of conditions in which the immune system destroys healthy hormone-producing tissues. These conditi...
UCLA ACE Administrative Core
PROJECT SUMMARY / ABSTRACT (ADMINISTRATIVE CORE) The Administrative Core provides critical infrastructure and services that support the proposed ACE research program. The overall g...
Defining the molecular regulation and physiological role of a novel lysosomal mechanism of adipocyte lipolysis
Project Summary: Adipose tissue is a dynamic energy depot that supports metabolic function and survival during fasting. When the ability of adipocytes to dynamically release energy...
Development of new tags for RNA visualization
PROJECT SUMMARY RNA plays numerous roles in biology. In addition to its canonical role in the central dogma as an intermediary between DNA genomes and protein products of translati...
Scalable Computational Methods for Genealogical Inference: from species level to single cells
PROJECT SUMMARY Massive amounts of genomic data are currently being generated, providing unprecedented opportunities for biomedical researchers to characterize various biological c...
Physical activity in South Asian Youth
PROJECT SUMMARY South Asian is one of the fastest growing ethnic groups in the United States (US). The striking overweight and obesity prevalence (78%) among foreign-born South Asi...
A community engaged approach to understanding Black fathers' experiences with perinatal care
ABSTRACT: Maternal mortality (MM) and severe maternal morbidity (SMM) have been on the rise, and racial disparities are widening. Rochester is the city with the highest Black MM/SM...
Examination of parent-adolescent shared decision-making about participation in pediatric clinical trials
ABSTRACT Pediatric clinical trials are important for discovering effective medicines, treatments, devices, and interventions designed for children and adolescents. However, recruit...
Using Behavioral Economics to Mitigate Relapse of Problem Behavior in an Intellectual and Developmental Disabilities Population
Project Summary/Abstract Over 2 million people in the United States who have intellectual and developmental disabilities (IDD) engage in some form of problem behavior such as self-...
Genomic regulation in ERF-related craniosynostosis
One of the most common craniofacial birth defects is craniosynostosis (CS), where connective tissue of the sutures that normally separate skull bones is prematurely replaced by bon...
Carrier Free siRNA Conjugates as Disease Modifying Osteoarthritis Drugs
PROJECT SUMMARY/ABSTRACT RNA interference (RNAi) using short interfering RNA (siRNA) is a promising strategy to block disease- causing targets that are difficult to selectively and...
Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV
PROJECT SUMMARY/ABSTRACT Insulin resistance is a driver of type 2 diabetes (T2D). Despite viral suppression, people living with HIV (PLWH) have concerningly high rates of both insu...
Role of Biomechanical Interfaces Created by Focal Adhesion Kinase in Catecholamine Signaling
Pioneering work by our MPI team established biomechanical signals as a critical driver of brown adipose tissue (BAT) function. We demonstrated a new signaling cascade in interscapu...
Technologies to enable safe and effective gene editing in skeletal muscle
Gene editing is moving towards the clinic, but several challenges must be addressed in order for it to be applied to skeletal muscle disease. Adeno-associated virus (AAV) is one of...
Immune responses associated with severe disease in patients with primary dengue infection
SUMMARY Dengue is an emerging global public health threat. Decades of extensive research undertaken primarily in dengue-endemic regions has resulted in the prevailing consensus tha...
Targeting EBV-associated lymphomas
ABSTRACT Epstein-Barr Virus (EBV) is the etiological agent of several hematopoietic malignancies including multiple types of non-Hodgkin lymphoma (NHL). These EBV-positive NHL subt...
Universal Test and Connect: A Pilot Study of Comprehensive HIV Service Delivery in Emergency Care Settings in South Africa
PROJECT SUMMARY South Africa continues to shoulder the highest burden of people living with HIV (PLHIV) in the world. In an effort to minimize the national burden of the HIV epidem...