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99,167 grants found
Showing 1,221 – 1,240 of 99,167 grants
Determinants of sex disparities in autoimmune endocrinopathies.
PROJECT SUMMARY / ABSTRACT (PILOT PROJECT) A number of autoimmune endocrinopathies are sex biased, with strong female predisposition For instance, female:male prevalence ratios hav...
Environmental enrichment reverses heroin-caused neural and behavioral adaptations in rats
Summary Abstract Heroin use disorder continues to be a serious and growing national health problem that requires an effective solution that produces long-term abstinence and preven...
Phase Changing Ultrasound Contrast Agents for Deep Tissue Imaging of Cellular Immunotherapies
PROJECT SUMMARY Adoptive cellular immunotherapies are an established therapeutic weapon in the fight against cancer. However, there is a large variability in anti-tumor responses a...
Enabling data quality assessment of organelle genomes archived on GenBank through novel open-source software tools
Project Summary/Abstract The project aims to enable scientists from various biomedical disciplines to make informed, evidence-based decisions on the reuse of archived organelle gen...
Aging, Burn Trauma, and Liver Damage
PROJECT SUMMARY This proposal investigates why burns cause more severe liver damage in older individuals and devises an innovative treatment strategy to counter this damage alongsi...
An Animal Model of Neonatal Intensive Care Unit Exposure to Light and Sound
SUMMARY: According to the World Health Organization, approximately 15 million children are born prematurely each year. Many of these infants end up spending days to weeks in a neon...
Identification of germline modifiers of Neurofibromatosis type 1 tumors
Abstract Neurofibromatosis type 1 (NF1) is a genetic disorder that occurs in about 1:3000 individuals. NF1 is caused by inheritance or de novo mutation/loss of the NF1 gene. Indivi...
Characterizing the Function and Regulation of Ycx1, a New Member of the CCX Family of Exchangers
Project Summary/Abstract Calcium ions play critical roles in regulating many biological processes. Mis-regulation of Ca2+ signaling can lead to diseases, and the Ca2+ channels and...
Hyperstable FGF1-FGF2 based therapeutic formulation for wound care
PROJECT SUMMARY Chronic wounds are a serious problem that affects the health and quality of life of patients with diabetes and cardiovascular diseases. These non-healing ulcers are...
Dicarboxylic acid therapy for prevention of kidney injury
ABSTRACT Acute kidney injury (AKI) most commonly occurs in the hospital setting. Hospital-acquired AKI accounts for 22% of all cases worldwide, and nearly 50% of critically ill inp...
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
PROJECT SUMMARY/ABSTRACT. Military-connected mothers (MCM; mothers who are either service members or veterans, or spouses of a service member or veteran) experience significant tra...
Estrogen and Serms as Therapy for Renal Ischemia Reperfusion Injury
Ischemia reperfusion injury (IRI) is a major source of morbidity in renal transplantation (Tx), as well as after cardiac arrest, cardiopulmonary bypass, and trauma. IRI and related...
Temporally scalable recording of brain-wide single-cell physiology
Abstract Many fundamental questions in neuroscience and neurological disorders, such as those associated with learning, memory, sleep, aging, and disease progression, would benefit...
Editing Population Codes For Action
Project Summary In the mammalian brain, action, perception, and cognition arise from the coordination of many neurons working in concert. For decades, neuroscientists have observed...
Individually Measured Endophenotypes to Advance Computational Translation in Mental Health
Stress-related psychiatric disorders (SRPDs) are now the leading disease burden worldwide and diagnoses are increasing in both adolescents and adults. High rates of trauma in the U...
In crystallo biomimetic oxygenase chemistry within peptidic frameworks
Title: In crystallo biomimetic oxygenase chemistry within peptidic frameworks Abstract: Mononuclear non-heme Fe and Cu sites in oxygenases functionalize the highly inert C–H bonds...
Genetics as a tool to improve phenotypes and associations with human disease
PROJECT ABSTRACT The Cole Lab’s overarching vision is to harness unique characteristics of the human genome to gain deeper insights into the impact of environmental risk factors on...
Vaping has an immunosuppressive effect, rendering the lung more susceptible to microbial infections
Project Summary/Abstract Respiratory disease carries a significant worldwide burden of morbidity and mortality. Currently it is well understood that tobacco smoking is a major caus...
Computational rational design of carbohydrate and nucleic acid drug scaffolds with multiscale dynamics and AI
ABSTRACT Computer aided drug discovery (CADD) can dramatically accelerate and lower costs for the often long and expensive process of drug development. However, most CADD technique...
Chemical approaches for targeting ribonucleoprotein assemblies
PROJECT SUMMARY RNA-protein interactions play a fundamental role in biology through complex processes regulating gene expression programs. Perturbation of native RNA-protein assemb...