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99,167 grants found
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Quantitative Assessment of Pelvic Floor Muscle Fitness in Myofascial Pelvic Pain
PROJECT SUMMARY Myofascial Pelvic Pain (MPP) is a frequently overlooked musculoskeletal cause of chronic pelvic pain affecting 10-20% of all adult women. Pelvic floor muscle tighte...
Feasibility of a music listening intervention for mental health recovery in chronic stroke
Project Summary This is a feasibility trial testing music listening as an intervention for mental health recovery after stroke. Stroke disproportionally affects older individuals a...
1/2 Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
PROJECT SUMMARY Premenstrual dysphoric disorder (PMDD) is a severe affective disorder impacting millions of women worldwide, thought to be due to impaired sensitivity to hormone fl...
Mechanistic etiology of developmental diseases caused by biallelic mutations in the mitochondrial Lon protease (111)
Summary Mitochondrial Lon is an ATP-powered protease that plays a pivotal role in regulating mitochondrial proteostasis, metabolism and cell stress responses. Biallelic mutations i...
CARES: An adherence support intervention for multiple PREP methods among adolescent girls and young women in South Africa and Zimbabwe
Adolescent girls and young women (AGYW) in South Africa and Zimbabwe are disproportionately affected by HIV. Daily oral pre-exposure prophylaxis (PrEP), bimonthly injectable PrEP,...
Scale-up of an evidence-based Adolescent Transition Package to support transitional care among youth living with HIV
ABSTRACT Youth living with HIV (YLH) have high rates of viral non-suppression and non-retention, particularly during the period when they transition from adolescent to adult autono...
Development of a new social media fMRI task to better investigate bidirectional links between social media use and emotional health in youth.
PROJECT SUMMARY/ABSTRACT There has been much interest in the potential role of social media (SM) use in driving a current mental health crisis among teens, with a dire need for evi...
Bidirectional relationships between positive and negative social media use and suicidal ideation in high-risk adolescents
PROJECT SUMMARY/ABSTRACT Suicide is a leading cause of death among adolescents in the US, with rates of suicidal ideation (SI) and behavior continuing to increase in recent years....
Reducing adipose tissue dysfunction and metabolic complications by manipulating sensory processing after spinal cord injury
ABSTRACT Half of the spinal cord injury (SCI) individuals experience weight gain attributed to increased adiposity. Following SCI, increased lipid deposition is also observed in ot...
Pathogen Transmission Dynamics among Wildlife and Human Settlements in Rural Western Uganda
Emerging diseases are a growing global problem, and wildlife pathogens are the principal source of disease. Human encroachment and climate change are increasing interactions betwee...
Molecular and Functional Taxonomy of Cardiovagal Neurons
PROJECT SUMMARY Heart rate is one of the most widely used and informative metrics of health. Yet, the neural circuits which determine heart rate are only partly known. Over a centu...
Emergence of arm reaching behavior and lateralization of motor control in infancy
It is crucial to understand how infants learn to progress from spontaneous movements into goal-directed, refined motor skills. Infant learning is the focus of early intervention pr...
Project 1: Implementing Risk-based Tools that Incorporate Tumor Biology to Optimize Screening and Prevention
In 2016, we initiated the first large-scale clinical trial to personalize screening based on individual risk, which varies significantly among women. The WISDOM Study is a multi-ce...
Examining Non-Congregate Shelter Effects on Mental Health Crises through Community Health Partnerships in Connecticut
PROJECT SUMMARY People experiencing homelessness have a disproportionate burden of mental illness and mortality than those who are not homeless. The environment in congregate shelt...
Core D: Patient Centered Outcomes and Risk Communication
CORE D: SUMMARY/ABSTRACT The ability to effect change in healthcare is as dependent on a successful implementation as it is on the intervention itself.Personalization of screening...
Epidemiology of the gut-liver axis and hepatocellular carcinoma risk in a multiethnic liver cirrhosis cohort: defining the role of bacteria, metabolites, and glycoproteins
PROJECT SUMMARY Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults in which most cases develop in patients with liver cirrhosis. The incidence and mor...
Project 2: Optimizing polygenic risk scores to inform breast cancer screening and prevention
PROJECT 2: Summary/Abstract The ongoing WISDOM Study of risk-based versus annual breast cancer screening is one of the first-ever applications of population-wide genetic testing to...
Project 3: Integration of mammographic AI, clinical, and genomics information to improve breast cancer subtype-specific risk-based screening and prevention
PROJECT 3: Summary The ongoing WISDOM risk-based breast cancer screening and prevention trial, which started in 2016, is a ground-breaking comparative effectiveness study to establ...
Mediators of chronicity in autoimmune endocrinopathies.
PROJECT SUMMARY / ABSTRACT (PRINCIPAL PROJECT) PRINCIPAL PROJECT: Molecular and cellular mechanisms of chronicity in autoimmune endocrinopathies Autoimmune endocrinopathies are chr...
Immune cell states in endocrine immune related adverse events (IRAEs)
PROJECT SUMMARY (COLLABORATIVE PROJECT) Immune-related adverse events (IRAEs) are an emerging group of endocrine autoimmune diseases that occur in many patients treated with immune...