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99,167 grants found
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A Pilot Feasibility HIV prevention Study Linking Incarcerated Women to Post-Release Pre-exposure prophylaxis (PrEP) Services
ABSTRACT This application proposes to adapt a Formerly Incarcerated Transitions (FIT) program for mostly African American women, often with health disparities, who are released fro...
Targeting GTP Cyclohydrolase 1 for treating chronic orofacial pain
PROJECT SUMMARY Chronic pain is a global healthcare problem that reduces the quality of patients’ lives and increases med- ical expenditures. Inadequate pain control with available...
Effect of the plantar skin microenvironment on tumor metastasis and drug tolerance
Project Summary Patients with advanced acral melanoma (AM) suffer worse outcomes relative to patients with cutaneous melanoma (CM), in part, because they do not respond as well to...
Impact of seizure onset pattern on temporal lobe seizure propagation through the basal ganglia
SUMMARY The objective of this proposal is to investigate how temporal lobe (TL) seizures with different onset patterns propagate through the basal ganglia (BG) and to evaluate the...
Vaccines and Therapeutic Antibodies to Respiro, Rubula, Peribunya and Phenuiviridae (R2P2)-ReVAMPP
SUMMARY. The Vaccines and Therapeutic Antibodies to Respirovirus, Rubulavirus, Peribunyavirus and Phenuivirus (R2P2) ReVAMPP Center will utilize both well-defined and novel approac...
Core A: Administrative Core
ABSTRACT – Core A: Administrative Core The Administrative Core A of the Vaccines and Therapeutic Antibodies to Respirovirus, Rubulavirus, Peribunyavirus and Phenuivirus (R2P2) ReVA...
Core B: Data Management Core
ABSTRACT Core B: Data Management Core Washington University (Miller, J. Philip) The overarching objective of the Data Management Core-B is to serve as the central hub for the analy...
Core C: Structure Core
PROJECT SUMMARY - Core C: Structure Core Structure-based vaccine antigen design is a key component of the prototype pathogen approach to pandemic preparedness. For each prototype p...
Core D: Antibody Core
ABSTRACT Core D: Antibody Core Washington University (Ellebedy, Ali) Respiroviruses, Rubulaviruses, Peribunyaviruses, and Phenuiviruses present major health burdens and have pandem...
Core E: Immunogenicity and Immune Correlates Core
ABSTRACT Core E: Immunogenicity and Immune Correlates Core (Correlates) The goal of Core E-Correlates will be to provide support to the projects by conducting various technical mea...
Prototype strategies for antibodies and vaccines for respiroviruses
Human parainfluenza virus type 3 (HPIV3) is the P1-Respiroviruses prototype for advancement of vaccines and therapeutic antibodies against respiroviruses due to the advanced state...
Prototype strategy for vaccines and antibodies to rubulaviruses
Project 2: Abstract Rubulaviruses are respiratory pathogens with a high level of transmissibility (R0 = 4-7). MuV is an ideal prototype pathogen to study paramyxoviruses because we...
Prototype strategy for vaccines and antibodies to Peribunyaviridae
SUMMARY. The long term goals of Project 3 of the Respiro, Rubula, Peribunya, Phenui (R2P2) ReVAMPP are to use a prototype pathogen approach to identify and validate generalizable v...
Design and development of generalizable countermeasures against prototype Phenuiviruses
PROJECT SUMMARY/ABSTRACT Prototype pathogens are those that, if well-characterized, can be used to develop generalizable medical countermeasures (MCMs) against new or unknown but r...
Core A: Administration, Communication and Project Management
CORE A: SUMMARY/ABSTRACT This Program Project comprises four individual projects, which will: extend the WISDOM Study to evaluate the use of subtype-specific risk models and associ...
Project 4: CISNET Modeling of outcomes and cost for risk-based screening strategies
Project 4 will evaluate the benefits, harms, and costs of personalized screening using one of the CISNET models of breast cancer. We will evaluate the current approaches to persona...
Core B: Biostatistics and Bioinformatics
CORE B: SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core’s primary goal is to collaborate with the P01 Investigators and other Core resource scientists to ensure that res...
Core C : Population Genomic Risk Assessment
CORE C: SUMMARY/ABSTRACT A polygenic risk score (PRS) combines risk information from many common genetic variants associated with a disease to predict the risk of that disease. PRS...
Insights into EHMT1 Variants in the Neurodevelopmental Disorder Kleefstra Syndrome through Structural Dynamics and Functional Analysis
Euchromatic histone methyltransferase 1 (EHMT1, also known as GLP) is a key histone methylation writer intricately associated with Kleefstra Syndrome (KS), a multifaceted neurodeve...
Human Embryonic Stem Cell Models for Studying Mechanisms Underlying Changes In Inhibitory Synapses in Down Syndrome
ABSTRACT: Down syndrome (DS), the chromosomal disorder caused by trisomy of chromosome 21 (Tri21), presents many neurological conditions, including intellectual disability (ID), au...