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99,167 grants found
Showing 101 – 120 of 99,167 grants
North Carolina Translational and Clinical Sciences Institute (NC TraCS)
Project Summary The North Carolina Translational and Clinical Sciences Institute (TraCS) is a dynamic regional network of universities, research institutes, healthcare providers,...
CTSA UM1 at the University of Alabama at Birmingham
ABSTRACT – The Center for Clinical and Translational Science (CCTS), the CTSA Hub at the University of Alabama at Birmingham (UAB), serves a region of the country with a dispropor...
An Intermediate-Size Expanded Access Protocol for Amyotrophic Lateral Sclerosis with Pridopidine
The Sigma 1 Receptor (S1R) has emerged as an attractive therapeutic target in ALS. Mutations in the S1R are causative of ALS and the degree of loss of function in S1R protein det...
Johns Hopkins Institute for Clinical and Translational Research
The Johns Hopkins Institute for Clinical and Translational Research (ICTR) has been a productive, innovative and impactful organization in transforming how clinical and translatio...
Education and Cognitive Functioning in Later Life: The Nation’s High School Class of 1972
PROJECT SUMMARY/ABSTRACT Education is among the most important determinants of later-life cognitive functioning and biological markers of AD/ADRD risk. However, we know very litt...
Phase II randomized controlled trial of benfotiamine in early Alzheimer's Disease
We propose a seamless Phase 2A-2B trial investigating benfotiamine, a prodrug of thiamine, as a first-in- class small molecule treatment for early Alzheimer's disease (AD). We cal...
Comprehensive single-cell atlas of the developing mouse brain
PROJECT SUMMARY The developing mouse brain is a foundational experimental model for investigation of the origins of cell types in the mammalian brain. Comprehensive knowledge of...
RhoFED AA-SCCC
PROJECT SUMMARY/ABSTRACT The cooperative agreement funded by this Funding Opportunity Announcement establishes an Asthma and Allergy Statistical and Clinical Coordinating Center...
Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis
Project Summary (Abstract) Gaining a comprehensive understanding of brain-wide cellular organization in the human brain has long been recognized as a critical foundation for unders...
Structure-based design of broadly protective coronavirus vaccines
PROJECT SUMMARY – OVERALL: Structure-based design of broadly protective coronavirus vaccines We propose a highly synergistic research Program focused on developing two broadly pro...
PPDs Application for the Transplantation Statistical and Clinical Coordinating Center (T-SCCC) (U01 Clinical Trial Not Allowed)
Project Summary/Abstract To support DAIT's efforts to increase understanding of the causes and mechanisms that lead to the development of immunologic diseases and to expand knowl...
RhoFED CDSMC
PROJECT SUMMARY/ABSTRACT The NIAID Clinical Data and Safety Management Center (CDSMC) is a consolidated clinical support service center conceived to manage NIAID’s portfolio of c...
RhoFED CDSMC
PROJECT SUMMARY/ABSTRACT The NIAID Clinical Data and Safety Management Center (CDSMC) is a consolidated clinical support service center conceived to manage NIAID’s portfolio of c...
Longitudinal multicenter head-to-head harmonization of tau PET tracers
Project Summary/Abstract: The development of tau positron emission tomography (PET) tracers has yielded the opportunity to better understand the tau accumulation associated with...
RhoFED AA-SCCC
PROJECT SUMMARY/ABSTRACT The cooperative agreement funded by this Funding Opportunity Announcement establishes an Asthma and Allergy Statistical and Clinical Coordinating Center...
Longitudinal multicenter head-to-head harmonization of tau PET tracers
Project Summary/Abstract: The development of tau positron emission tomography (PET) tracers has yielded the opportunity to better understand the tau accumulation associated with...
Longitudinal multicenter head-to-head harmonization of tau PET tracers
Project Summary/Abstract: The development of tau positron emission tomography (PET) tracers has yielded the opportunity to better understand the tau accumulation associated with th...
PPDs Application for the Transplantation Statistical and Clinical Coordinating Center (T-SCCC) (U01 Clinical Trial Not Allowed)
Project Summary/Abstract To support DAIT's efforts to increase understanding of the causes and mechanisms that lead to the development of immunologic diseases and to expand knowl...
Interactions of SARS-CoV-2 infection and genetic variation on the risk of cognitive decline and Alzheimer’s disease in Ancestral and Admixed Populations
The science proposed in this program takes advantage of the unique scientific opportunity created by the ongoing coronavirus pandemic, to study the interaction between a definable...
B and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection
ABSTRACT The Emory Consortium for Innovative HIV/AIDS Vaccine and Cure Research in Nonhuman Primates aims to define the mechanisms of the B and T Cell Biology of Protection from...