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99,167 grants found
Showing 101 – 120 of 99,167 grants
Pre-clinical testing of a novel gene therapy for pediatric neurodegenerative disease
PROJECT SUMMARY A significant number of pediatric neuromuscular and neurodegenerative conditions are caused by recessive gene mutations resulting in loss of both maternal and pater...
Elucidating the Role of TGF-Beta Signaling in Craniofacial Fibrous Dysplasia of the Bone
PROJECT SUMMARY: Craniofacial fibrous dysplasia (CFD) is a disabling skeletal disease with no curative medical therapies. It is characterized by fibrotic, expansile bone lesions th...
Center on the Ethics of Indigenous Genomic Research
Summary American Indian and Alaska Native (AI/AN) concerns about genomics are well documented but are too often left unaddressed. The failure to authentically engage AI/AN communit...
Nuestro Valor: Increasing healthier food access for rural Latino communities through a food retail intervention
Project Abstract Diets low in fruits and vegetables are associated with chronic disease disparities for Latinos living in rural areas. Furthermore, in rural areas, structural and s...
Dynamic Functional Mapping of Alzheimer's Spectrum and HIV-related Brain Dysfunction
Project Summary/Abstract Mild cognitive impairment (MCI) remains a critical problem in patients infected with HIV, but it is also commonly seen in patients with diabetes, early Alz...
Longitudinal Impact of Fluoride on Neurodevelopment and Neuroimaging Outcomes During Childhood and Adolescence in the United States and Mexico
Exposure to fluoride is ubiquitous in many developed countries including the United States and Mexico due to fluoridation of water and salt, respectively. Several studies from Cana...
The Role of Residential Bioaerosol Exposure in Pulmonary Sarcoidosis
Summary/Abstract Sarcoidosis a rare systemic inflammatory disease with high morbidity and increasing mortality. Granulomatous inflammation affects the lungs in 90% of cases, with ~...
A framework for interpreting global effects of genetic variants contributing to disease risk
Advances in next-generation sequencing are enhancing the routine detection of human genetic variants, particularly in clinical settings. Yet, the ability to interpret the functiona...
Alleviating antibiotic-induced microbiome dysfunction by quenching the microbial redox environment
PROJECT SUMMARY Antibiotic-induced disruption (AID) of the gut microbiome can lead to severe conditions like C. diff colitis and may contribute to long-term health issues, includin...
Identifying and characterizing human pulmonary neuroendocrine stem cells and their diversity
PROJECT SUMMARY Pulmonary neuroendocrine cells (PNECs) are sensory epithelial cells that signal to the brain through sensory neurons and locally through neuropeptides and neurotran...
Multi-Lineage Modulation of cardiac neural crest cells during cardiac development
Project Abstract Congenital heart disease (CHD) is the most common birth defect with complex CHD causing significant morbidity/mortality. Therapies targeting adult heart failure ha...
The Impact of Underlying Behavioral Mechanisms on a Home-Based Pulmonary Rehabilitation Program
PROJECT SUMMARY/ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is one of the top five causes of disability among middle-aged US adults. Exercise-based pulmonary rehabilitati...
Sex Differences in Gut Metabolite-Immune Interplay in Hypertension and Renal End-Organ Damage
PROJECT SUMMARY/ABSTRACT Nearly half of the ~116 million Americans with hypertension are salt-sensitive and confer a 3-fold higher risk of developing cardiovascular disease. Only 2...
Development of lesion-targeted lncRNA nanotherapeutic for vascular smooth muscle dysfunction
PROJECT SUMMARY Neointimal hyperplasia (NIH) is a significant issue that arises from vascular damage during interventions, leading to arterial wall thickening and lumen loss. This...
Determining the Mechanisms of Radiation Biomodulation of the Ventricular Tachycardia Arrhythmogenic Substate
Project Summary Cardiovascular disease is the leading cause of death in the United States and accounts for 1 in every 5 deaths. Sudden cardiac death is responsible for nearly half...
Effectiveness of Therapies for Heart Failure with Mid-Range Ejection Fraction
Project Summary / Abstract Evidence from trials has established that 4 separate classes of guideline-directed medical therapies (GDMT) for heart failure with reduced ejection fract...
Pilot multisite randomized controlled trial of yoga to reduce depression inadolescents
PROJECT SUMMARY Even before the onset of the COVID pandemic, adolescent depression has been increasing, and health dispar- ities and disparities in access to treatment have continu...
Comprehensive Determination of Isoprostanoid Metabolism
PROJECT SUMMARY Oxidative stress (OxS) is a biochemical process that leads to damage of cellular lipids when endogenous redox homeostasis is disrupted. OxS is mechanistically linke...
Targeting endothelial cell metabolism to improve recovery from acute ischemic stroke in older mice.
Here we interrogate a novel therapeutic strategy for improving outcomes of acute ischemic stroke (AIS) in older mice. We will test whether amplifying endothelial cell (EC) autophag...
Viral determinants of Bacterial Vaginosis and HIV acquisition risk in the female genital tract
The female genital tract (FGT) is colonized by millions of microbial taxa that have far reaching effects on reproductive health. Resident bacteria in the FGT affect mucosal immune...