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99,167 grants found
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A multiscale approach to develop and apply fluoride efflux inhibitors to reverse oral dysbiosis and eliminate early childhood caries
PROJECT SUMMARY/ABSTRACT The problem: Early childhood caries (ECC) is a lead health problem affecting children. More than half a billion children worldwide have untreated tooth dec...
HIV Drug Resistance in the New Antiretroviral Therapy Era in Kenya
HIV Drug Resistance in the New ART Era in Kenya Rami Kantor, MD SUMMARY Since the emergence of resistance to zidovudine in the late 1980’s, we have been in a race: an HIV drug is d...
A novel GTPase regulator governing the regenerative capacity of murine teeth
Project summary/Abstract MSCs play critical roles in tissue turnover and injury healing processes, making them highly valuable in the field of regenerative medicine. The murine tee...
Enhanced Digital Access to Bridge Social Needs and Reduce Health Disparities: The e-SINCERE Study
PROJECT SUMMARY Social context is tied to health outcomes, driving the rapid adoption of screening for tangible social needs (e.g. for housing, utilities, food) by healthcare syste...
Oral and Craniofacial Bone Regeneration using MicroRNA Modulation
Project Summary More than 20% of oral squamous cell carcinoma (OSCC) patients present with bone invasion and require maxillary/mandibular continuity restoration after tumor excisio...
Continuity of User-Centered Design of a Proactive RF-Based Wearable Bladder Monitor for Toilet Training of Children with ASD/IDD
Project Abstract Urinary incontinence (UI) and difficulties with toilet training are significant and common challenges faced by childrenand young adults with autism spectrum disord...
Identifying inter-kingdom microbial determinants of altered immunity in HIV exposed infants
PROJECT ABSTRACT Infants born to HIV-infected mothers are at high risk for HIV acquisition. Additionally, HIV-exposed yet uninfected infants display reduced vaccine responses and i...
The Development of Youth Resilience to Neighborhood Disadvantage
Project Summary/Abstract Much of the youth resilience literature to date has focused on resilience to family adversity, with far less examining resilience to neighborhood adversity...
Grounding models of category learning in the visual experiences of young children
PROJECT SUMMARY Early word learning is a major developmental achievement that rests on a foundation of visual category learning: to learn that the word “dog” refers to a category d...
Machine Learning-enabled Classification of Extracellular Vesicles Using Nanoplasmonic Microfluidics
PROJECT SUMMARY/ABSTRACT Ovarian cancer is a diverse group of malignancies that can vary greatly in molecular biology, etiology, and presentation of symptoms. While it accounts for...
A mobile health tool to improve antibiotic stewardship among village doctors in Bangladesh
Abstract Diarrheal diseases are the among the leading cause of death in children worldwide, most of which occur in low- and middle-income countries (LMICs). The cornerstone for man...
Evolution of Mammalian Sex Chromosome Dosage Compensation
Abstract Mammalian dosage compensation equalizes X-linked gene expression between XX females and XY males. Defective dosage compensation can cause cell and organismal lethality. Cu...
Exploring synergies in pharmacy-based delivery of PrEP and contraception for adolescent girls and young women in Kenya
PROJECT SUMMARY/ABSTRACT Adolescent girls and young women (AGYW; age 15-24) in East and southern Africa are disproportionately affected by poor sexual and reproductive health (SRH)...
Feasibility, acceptability, and preliminary efficacy of an adapted group-based and online HIV prevention intervention for immigrant sexual minority men in the US
Project Summary In 2014, the immigrant population in the United States (US) was 42 million and is projected to reach 78 million by 2060, a growth of 85%; an estimated 3% of immigra...
Ultra-High Field NMR Magnets with Multifilament High Temperature Superconductors
PROJECT SUMMARY We propose to develop a new technology pathway towards 1.5 GHz 1H NMR, by building a 28.2 T (1.2 GHz 1H)/1ppm, all-superconducting NMR demonstrator magnet using coi...
WISDOM: A platform to optimize subtype-specific screening and prevention
The WISDOM Study, that includes 45,000 women in the US, is the first large-scale study of a risk-based approach to breast cancer screening. Its goal is to determine if risk-based s...
Developing, Implementing and Supporting NCI Clinical Trials and the National Cancer Trials Network (NCTN) in Breast Cancer and Developmental Therapeutics- A 5 Year Plan
Project Summary/Abstract Dr. Ciara O’Sullivan is a medical oncologist focusing on clinical and translational research in breast cancer (BC) and developmental therapeutics. Her rese...
Gynecologic cancer care: Improving clinical trial enrollment through molecular matching with targeted therapies and improving equal access to care and research for all populations
Project Summary/Abstract Gynecologic Cancer remains an underfunded area of research with funding to lethality scores significantly lower than other cancer sites. Endometrial cancer...
An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation
ABSTRACT Cigarette smoking is the leading cause of preventable death and disability in the United States. Smoking cessation rates have stagnated in recent years, underscoring the n...
Pediatric toxoplasmosis: Addressing unmet medical need with 3D printed dose flexible delivery systems of pyrimethamine, sulphadiazine and leucovorin
ABSTRACT / PROJECT SUMMARY Toxoplasmosis is a life-threatening food-borne/congenital disease that can have severe implications in immuno-compromised children. The US Center for Dis...