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99,167 grants found
Showing 1,141 – 1,160 of 99,167 grants
Radiomic biomarkers for clinical decision support that predict patient outcomes in serous ovarian carcinoma
ABSTRACT Less than a third of women diagnosed with advanced epithelial ovarian cancer (EOC) survive five years after diagnosis. Despite therapeutic improvements over time, patient...
Ribosomal RNA modification in nucleoli and disease
ABSTRACT Nucleoli produce 1-10 million ribosomes per cell. They are membraneless organelles in the nu- cleus formed by liquid-liquid phase separation (LLPS). Dysregulation of ribos...
Thrombospondin-1's role in heart failure with preserved ejection fraction (HFpEF)
PROJECT SUMMARY Heart failure with preserved ejection fraction (HFpEF) is the predominant form of heart failure and its incidence continues to rise. HFpEF disproportionately affect...
Functional Dynamics of Neurotransmitter:Sodium Symporters (NSSs)
Neurotransmitter:sodium symporters (NSS), the target of therapeutic and illicit drugs, share a common structural core, e.g., the LeuT fold, with secondary transporters that harness...
Developmental programs as vulnerabilities in H3.3G34-mutant high-grade glioma
Abstract/Project Summary Brain tumors are the leading cause of cancer-related deaths among children. Recent studies have identified new subtypes of brain tumors, including high-gra...
Building Stochastic Actor-Oriented Models to investigate social network influences on youth nicotine product use transitions and to simulate different intervention effects across contexts
PROJECT SUMMARY In the United States, Mexico, and in many countries around the world, teens’ combustible cigarette (CCs) use has declined in recent years, yet that progress is thre...
Monitoring Human Exposome with Extracellular Vesicle Tricorder
ABSTRACT With escalating challenges of climate change and social inequality, there is an urgent need for tools that can monitor the influences of the exposome on human health acros...
Targeted Degradation of Extracellular Proteins to Enhance Brain Plasticity
PROJECT SUMMARY The young brain displays remarkable plasticity. This includes an ability to remodel neuronal synaptic connections to learn new tasks in health, as well as being abl...
Multidimensional and longitudinal immune profiling of sepsis in Uganda
PROJECT SUMMARY The global burden of sepsis is overwhelmingly concentrated in sub-Saharan Africa (SSA), where nearly 40% of all sepsis cases occur and up to 65% of all deaths are s...
Multi-omic liquid biopsy assessment in NCI trials: evaluating ctDNA, extravesicle RNA, and outcomes with immunotherapy in patient with colorectal and anal cancers
My long term goal as a clinical scientist at MD Anderson Cancer Center is to lead clinical trials that improve survival for patients with gastrointestinal malignancies, particularl...
Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics
The opioid crisis is a pressing global issue, highlighting the need for exploring new targets with unique mechanisms of action. Extracellular adenosine is known to relieve pain by...
Causally-Sufficient Dimensionality Reduction Methods for Assessing Joint Effects of Air Pollution Mixtures on Health Outcomes
ABSTRACT. Air pollution constitutes a multifaceted environmental challenge with far-reaching implications for public health and policy formulation. This research aims to deepen our...
Development and Clinical Translation of RPBM for Quantitative Assessment of Myofascial Pain
PROJECT SUMMARY Our goal is to develop and assess the clinical potential of quantitative imaging biomarkers of masticatory myofascial pain syndrome (MMPS). MMPS afflicts nearly 10%...
Overcoming treatment-resistant gynecological cancers by combination of DNA damage response inhibitors
Project Summary About 50% of high grade serous ovarian cancers (HGSOC) exhibit defects in homologous recombination (HR; e.g. BRCA1/2 mutations). Approximately 20% HGSOC and 50% of...
Imaging and computational platform for integrated analysis of biodata
PROJECT SUMMARY Here we propose a novel technological platform that enables rapid and unbiased analysis of entire organs at subcellular resolution. An example of application is to...
Molecular Assembly on the Cell Surface of Actinomyces
PROJECT SUMMARY Dental plaque represents one of the most complex microbial communities or biofilms known to affect humans. Oral biofilm-related diseases, e.g. dental carries, gingi...
Optimized High-Resolution Fast Magnetic Resonance Fingerprinting with Cloud-Based Reconstruction
Optimized High-Resolution Fast Magnetic Resonance Fingerprinting with Cloud- Based Reconstruction Abstract Magnetic resonance imaging (MRI), despite its wide utility, is inherently...
Trpc5-activated neural circuits and maternal behavior
PROJECT SUMMARY Parental behavior is the hallmark feature of all mammals, and is critical to the health of both parents and offspring. In the majority of mammals, since only the fe...
Mechanisms of S100A9-mediated brain metastasis
Approximately 50% of patients with EGFR-mutant lung cancer develop brain metastasis (BM), which is associated with poor prognosis and accelerated mortality. There is a long-term un...
Methods for characterizing mechanobiology of the tumor microenvironment landscape
Cells within the tissue microenvironment sense, process and respond to mechanical cues from their environment. This mechanosensing is essential for tissue homeostasis, and its dysr...