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99,167 grants found
Showing 1,121 – 1,140 of 99,167 grants
Whole Body Deep Tissue Characterization of the Human Virome
SUMMARY/ABSTRACT The virome is heterogenous and widely distributed across the whole body. Given the challenges of obtaining deeper tissues from healthy individuals, however, it is...
Establishment of yolk sac organoids for developmental toxicity assessment
Proposal Abstract The yolk sac is an extra-embryonic organ that is vital for early embryo development, serving as the nutrient supply center during the first trimester. It absorbs...
Innovative Network on the Science and Practice of Implementation, Research, and Engagement Center (INSPIRE)
ABSTRACT The Innovative Network on the Science and Practice of Implementation, Research, and Engagement Center (INSPIRE) seeks to advance the science and practice of dissemination...
Advanced Methods & Modeling (AMMC)
Advanced Methods and Modeling Core Abstract The Advanced Methods and Modeling Core (AMMC) is dedicated to advancing cutting-edge methods and modeling techniques to enhance the unde...
Community Engagement & Dissemination (CEDC)
Community Engagement and Dissemination Core Abstract The Community Engagement and Dissemination Core (CEDC) plays a pivotal role in the PATC3H-IN network by emphasizing community e...
Implementation Science Capacity Supporting (IS-CSC)
CAPACITY SUPPORTING CORE ABSTRACT The Innovative Network on the Science and Practice of Implementation, Research, and Engagement (INSPIRE) Capacity Supporting Core seeks to leverag...
Role of N-terminal acetylation in alpha synuclein stability, function, and therapeutic targeting in synucleinopathies
Project Summary Decades of genetic and experimental evidence has placed α-synuclein (αS) as a central player in the pathogenesis of several neurodegenerative diseases including Par...
Enhancing Novel Research for Inflammation and Cognitive Health among Adolescents and Young Adults Living with Perinatally Acquired HIV and Adversity (ENRICH+)
Neurocognitive impairment (NCI) is one of the most prevalent and deleterious complications observed in adolescents and young adults (AYA) with perinatally acquired HIV (PHIV), even...
Advancing oral health equity through integrating patient, provider, and population-based approaches
PROJECT SUMMARY/ABSTRACT The goal of this research program is to advance oral health equity through strengthening the scientific basis for innovations in population approaches to i...
Center for Research and Education in Multiscale Bioengineering, Bioimaging, and Biosensing
Center Research and Education in Multiscale Bioengineering, Bioimaging, and Biosensing Summary: In this HBCU BEITA project we propose to establish an interdisciplinary Center for R...
Elucidate the mechanisms of ferroptosis mediated by nonconjugated and conjugated polyunsaturated fatty acids
Project Summary. Ferroptosis is a regulated form of cell death that is dependent on iron and driven by lipid peroxidation. Glutathione peroxidase 4 (GPX4) plays a central role in i...
Precision Mapping of Knee Pain in Osteoarthritis: Understanding differences between pain with activity and rest
PROJECT ABSTRACT This career development award focuses on training Dr. Bella Mehta (applicant) on pain phenotyping in osteoarthritis (OA) patients and linking phenotyping data to t...
An effective statistical inference framework to develop innovative compensations for protein mutations
Understanding protein mutations requires learning which specific mutations disrupt a protein's function and offers the opportunity to further understand how to restore the nor...
Quantitative Photoacoustic Imaging Biomarkers for Characterization of Thrombosis
PROJECT SUMMARY Thrombosis is the major underlying pathology that causes many cardiovascular diseases including stroke, ischemic heart disease, and venous thromboembolism (VTE). VT...
DMS/NIGMS 2: Moment Kernel Machines for Decoding Complexity in Dynamic Biological Networks
Conducting an accurate yet simple mathematical description of large-scale dynamical networks, such as biological networks, is an essential yet challenging step toward enabling desi...
Protein ubiquitination and deubiquitination in neurological disorders
Abstract Protein ubiquitination is a posttranslational modification that is essential for nervous system function. UB requires the utilization of a series of enzymes called E1, E2,...
Next Generation GPC2-CARs for Medulloblastoma
Project Summary Progress against pediatric solid tumors has stalled. Current standard therapies largely employ dose intensive cytotoxic agents developed in the 1970s and 1980s that...
PHAGE-ENABLED MINING OF GUT METAGENOMES FOR TERPENOID AND CAROTENOID METABOLISM
ABSTRACT Terpenoids are the largest class of naturally occurring small molecules. While the majority of terpenoids originate from plants and fungi, bacteria are also capable of pro...
Epigenetic mechanisms of HAND pathogenesis
HIV-associated neurocognitive disorders (HAND) remain among the most prominent HIV co-morbidities in the era of ART-treated HIV infection. Persistent neuroinflammation is a recogni...
Magnetic resonance imaging methods to track Treg distribution and homing for clinical applications
PROJECT SUMMARY Regulatory T cell (Treg) infusion, alongside solid organ transplantation, is an emerging strategy which focuses on rebalancing the Treg ratio in the transplanted or...