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99,167 grants found
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Aging-related hematopoietic stem cell intrinsic and microenvironmental signals in AML transformation
Summary Acute myeloid leukemia (AML) is a disease of the elderly that often transforms from pre-AML states of age- related clonal hematopoiesis (ARCH), myelodysplastic syndromes (M...
Core A: Administrative Core
The objective of Core A is to supervise and facilitate overall progress of the scientific work of the Program. Specifically, scientific management is combined in this Core with adm...
Project 1: Role of emergency myelopoiesis as a driver of clonal evolution in AML
PROJECT DESCRIPTION Our overall goals are to establish (i) whether the hijacking of emergency myelopoiesis (EM) pathways represents a shared mechanism of leukemogenesis in the cont...
Project 2: Microenvironmental and inflammatory mechanisms in MDM4-driven AML pathogenesis.
Project Summary/Abstract Recent studies have demonstrated the existence of preleukemic (preL) HSPC (which includes the phenomenon of age-related clonal hematopoiesis (ARCH)) in hum...
Project 3: Role of stromal cell-activated CNOT6L deadenylase in driving AML transformation
Role of stromal cell-activated CNOT6L deadenylase in driving AML transformation. AML has long been thought to be exclusively driven by genetic or epigenetic mutations within HSCs....
Core B: Computational Genomics Core
Core B: Computational Genomics Core. Core Director: Raul Rabadan The Computational Genomics Core will provide a centralized structure to collect, analyzed and integrate data from a...
Point of Care Detection and Diagnosis of Oral Cancer using a Low Cost Imaging Module enabled by AI
PROJECT SUMMARY/ABSTRACT The overall vision of the proposed project is to to develop and deploy an affordable automated point-of-care (POC) telecytology platform for oral cancer sc...
Microbiota and Extracellular Matrix Interactions that Drive Host Tissue Remodeling
PROJECT SUMMARY Knowledge about the human microbiome has increased exponentially in the last twenty years, leading to its association with a wide variety of conditions and diseases...
BLOOD-BASED PROTEOMIC ASSAY FOR PANCREATIC CANCER DETECTION
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that is usually asymptomatic at an early stage. In addition, metastases can be present even when the cancer size is rela...
Modulation of host immunity with recombinant peptidoglycan hydrolases
PROJECT SUMMARY There exist few preventive or therapeutic modalities for vulnerable hosts against bacterial diarrheal illness. Further, the limited effectiveness of anti-infectives...
Planning grant for Take Off Pounds Sensibly (TOPS) for African American (AA) Cancer Survivors
1. Abstract Our long-term goal is to decrease the weight-related breast cancer and cardiovascular disease mortality among African American breast cancer survivors. In the R01 appli...
Robust Computational and Data Analytic Tools for In-depth Understanding Postoperative Pain Mechanism with Enhanced Pain Management and Clinical Decision Making
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.
Dissecting Molecular Mechanisms of Tumor-Induced Myeloid-Mediated Immune Suppression in Triple-Negative Breast Cancer
PROJECT SUMMARY Breast cancer remains the leading cause of cancer-related mortality in women worldwide. Despite considerable progress in the treatment of early-stage disease, a sig...
Immunogenomics platform for the analysis of cancer
ABSTRACT The goal of this proposal is to provide support for my main roles as a Laboratory-based Research Specialist in my Unit Director Dr. Timothy Chan’s research program and as...
Optimization of strategies to improve NCI-sponsored clinical trial participation throughout the Weill Cornell Medicine - Meyer Cancer Center Sphere
Optimization of strategies to improve NCI-sponsored clinical trial participation throughout the Weill Cornell Medicine - Meyer Cancer Center Sphere The Meyer Cancer Center (MCC) of...
Enhanced Delivery of Cytotoxic Neural Stem Cells for Treatment of Glioblastoma Multiforme Using an Innovative In-situ Thermogelling Hydrogel and Focused Ultrasound
PROJECT SUMMARY Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer and ~90% of GBM patients die within 24 months after diagnosis.1 Treatment options for GBM...
Maternal obesogenic diet-induced changes in embryo and fetal DNA methylation programming
PROJECT SUMMARY Obesity in reproductive-age women has sharply increased over the past few decades and is expected to continue to rise for the foreseeable future. Besides a greater...
Building Capacity for Youth Mental Wellness: Feasibility and Acceptability for a Mental Health Family Navigator Model for Foster Parents.
Goal: This R34 study will pilot the Family Navigator Plus (FN+) program for foster parents to increase access to mental health (MH) services for children in foster care aged 6-17....
Discovering the mechanisms underlying oncogenesis by ZFTA-RELA and pinpointing therapeutic targets.
PROJECT SUMMARY: Ependymoma (EPN) is an aggressive and chemo-resistant pediatric brain tumor, with treatment remaining surgery and radiation. There are no targeted therapies availa...
Screening of US and Jordanian Natural Product Libraries for the Discovery of Blood Brain Barrier (BBB) Penetrant Cathepsin L Inhibitors for the Treatment of Chronic Pain
Project Summary/Abstract Chronic pain is a debilitating condition that is widely treated with prescription opioid drugs over extended periods of time. The high prevalence of opioid...