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99,167 grants found
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Clinical Spectrum and Societal Impact of Cognitive Impairment with HIV in Uganda
As over 25 million people living with HIV (PWH) in sub-Saharan Africa (sSA) reach older age, determining their risk for and causes of mild cognitive impairment (MCI) and Alzheimer’...
Financial Impact of Support and Care in Alzheimer's disease and Related Dementias (FISCAL)
Family caregivers provide much of the support to people with Alzheimer’s disease (AD) and AD-related dementias (ADRD) living in the community. As a result, caregivers for people wi...
Mechanism of lysyl oxidase propeptide in oral squamous cell carcinoma microenvironments
Oral cancer is the 6th most common cancer, mostly tongue oral squamous cell carcinoma (OSCC). Surgery and radiation treatments result in severe quality of life issues, tissue stiff...
Social Connectedness, Loneliness, and Health Among Aging Black Sexual Minority Men
SUMMARY/ABSTRACT Health disparities affecting older adults reflect disparities across the life span with the added burden of ageism. Black sexual minority men (BSMM) in particular,...
Role of Home-based Medical Care and Telemedicine in Care and Outcomes of Dementia and Coexisting Conditions in Public and Private Medicare
Home-based medical care (HBMC) is essential for the growing population of community-living persons with Alzheimer's Disease and Related Dementias (ADRD). People living with AD...
Uncovering novel heme chemistry in microbial systems
Project Summary In nature, metalloenzymes make up approximately one third of the known enzymes and play central roles in biological processes such as photosynthesis, respiration, a...
Mechanisms that regulate erythroid differentiation of hematopoietic stem cells
Hematopoietic stem cells (HSCs) are capable of regenerating the entire hematopoietic system. This capacity is fully unleashed upon bone marrow transplantation, however, recent stud...
Neuropeptide S Receptor 1 as a Novel Target for Reducing Opioid Self-Administration and Opioid Relapse
SUMMARY Opioid dependence is a global public health issue for which more effective treatments are urgently needed. Opioid dependence is characterized by exacerbated brain stress si...
Multiomic methods for the characterization of cellular aging
PROJECT SUMMARY Age-related diseases are together the leading causes of death in the United States, and drugs targeting basic mechanisms of aging have recently entered clinical tri...
High-speed 4D echocardiography system with adjustable multi-planar acquisition
PROJECT SUMMARY/ABSTRACT 4D transthoracic echocardiography (TTE) offers an excellent means to study complex heart anatomy and measure cardiac dynamics via myocardial strain imaging...
GeNYC: Genomic Implementation Research in the Diverse Settings and Populations of New York City
Project Summary The promise of genomic medicine to transform healthcare and improve health will not be fully realized until discoveries become relevant to and available for use by...
Continuous glucose monitoring for management of type 2 diabetes in pregnancy (CGM2 trial)
There is a fundamental knowledge gap in achieving maternal glycemic control sufficient to reduce maternal and neonatal morbidity and mortality in pregnant individuals with type 2 d...
Immunological mechanism of muscle-localizing self-replicating RNA vaccines
PROJECT SUMMARY/ABSTRACT As evident in the ongoing “tripledemic” of severe acute respiratory syndrome-Coronavirus-2, Respiratory Syncytial virus, and Influenza virus, as well as re...
Genetic circuits for targeted modulation of neuroinflammation
Project summary/Abstract Neuroinflammation plays a critical role in neurodegenerative diseases and cognitive functions. Current methods to study neuroinflammation in animal models...
Nurses Surviving Breast Cancer: An exploration of breast cancer diagnosis, reported lymphedema symptoms, and lifestyle status in the Nurses' Health Study Survey
Project Summary/Abstract Breast cancer-related lymphedema (BCRL) is a side-effect of anticancer treatment. Caused by damage to the lymphatic system secondary to surgery, chemothera...
Planning to implement high-quality active surveillance in new-onset favorable risk prostate cancer
Project Summary Many men with favorable-risk prostate cancer do not benefit from aggressive intervention. As a preferred alternative, active surveillance is increasingly used to sp...
SESAME: Sun Exposure and Activities after Skin CAncer: Optimization of Mhealth IntErventions
ABSTRACT There are currently 1.36 million melanoma survivors in the US, and this number is expected to increase to 1.92 million by 2030. Most melanoma patients (92%) survive 5 or m...
Support for bereaved friend and family caregivers of cancer patients
Bereaved friend and family caregivers have taken on the burden of end-of-life care for patients with cancer who die in hospice care at home. Bereavement can be emotionally devastat...
Untangling the influence of distinct sources of somatosensory feedback on the neural dynamics of dexterous movement control
PROJECT SUMMARY To move successfully, we must be able to sense our bodies and our environment. This is no more evident than when participants attempt to strike a match to light a c...
Integrating U=U into HIV counseling: a cluster-randomized efficacy trial (INTUIT 2.0)
Project Summary The elimination of HIV transmission with virally-suppressive antiretroviral therapy (ART) has provided the world with a clear path to end the HIV epidemic through t...