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99,167 grants found
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Social Visual Attention and Language Development in Autism: Leveraging Infant-Directed Speech and Song to Identify Multimodal Mechanisms of Communication
Language ability is a strong and consistent predictor of outcomes for individuals on the autism spectrum (ASD). ConsequenUy, understanding key predictors and mechanisms underlying...
Identification and Characterization of Senescent Cells in Molecular Subtypes of Alzheimer's Disease
Alzheimer's disease (AD) remains uncurable. The complex, and diverse, neuropathology suggests that AD may actually represent not a single disease, but a family of diseases tha...
Therapeutic targeting mesenchymal transition in newly diagnosed and recurrent GBM
PROJECT SUMMARY IDHwt glioblastoma (GBM) patients still live an average of ~15-months, despite advances in multimodal therapy. A central issue confounding treatment is the heteroge...
Gender and sex dimorphism in age-related knee osteoarthritis
ABSTRACT As indicated by the 2019 Global Burden of Disease Study, although women, on average, have a longer lifespan than men, women typically experience worsened health outcomes a...
P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India
PROJECT SUMMARY/ABSTRACT While it is widely acknowledged that Alzheimer’s disease and related dementias (AD/ADRD) have an extended preclinical phase, there are sparse data on the c...
Aversive midbrain glutamatergic regulation of the locus coeruleus during opioid withdrawal
Fentanyl and other synthetic opioids are killing thousands of Americans each year. The overall goal of this research is to better understand the role of the primary central noradre...
Community-derived Multilevel-Multicomponent Nutrition Intervention to Reduce Food Access Disparities -FRESH-EATS
PROJECT SUMMARY The prevalence of diet-related diseases and health conditions such as obesity, diabetes, and cardiovascular diseases are higher among Black/African-Americans (AA) i...
Evaluating a tobacco harm reduction strategy among clients enrolled in substance use disorder treatment
PROJECT ABSTRACT The prevalence of cigarette smoking among individuals with substance use disorders (SUD) is nearly three times higher than the prevalence of smoking among the gene...
Computation-aided Molecular Design of DNA-Inspired Janus Base Biomaterials for Intracellular Delivery
Abstract The overall goal of this proposal is to develop novel biomaterials for intracellular therapeutics delivery. While messenger RNAs (mRNAs) are recognized as promising candid...
Theoretically Informed Behavioral Intervention to Enhance QOL and Prevent HIV-related Comorbidities in Ethnic and Racial Sexual Minority Men
Project Summary Black and Latinx gay and bisexual men are at highest risk of comorbid conditions resulting from HIV. Cardiovascular disease has become the leading contributor to mo...
Phase II Evaluation of Tirzepatide in Adults with Alcohol Use Disorder and Overweight or Obesity
PROJECT SUMMARY Alcohol use disorder (AUD) and overweight/obesity (OOB) are highly prevalent conditions that contribute substantially to global disease burden. Alongside recent inc...
Hair-greying and melanocytic regulation of BCL2 in a non-model organism
Project Summary/Abstract Hair-greying is an early and visible sign of aging with important psychosocial, commercial, and biologic implications. The underlying mechanisms of hair-gr...
Circadian regulation of mitochondrial function by muscle RORs to promote healthy aging
PROJECT SUMMARY / ABSTRACT A fundamental challenge in our rapidly aging society is how to extend healthspan, or maintain robust fitness without major diseases. The circadian clock,...
Deep TMS Neuromodulation of Neural Circuits Associated with Stimulant Use Disorder
ABSTRACT Background: Converging lines of evidence suggest that neuromodulation of the neural circuits underlying methamphetamine use disorder (MUD) and subsequent relapse may be an...
Comprehensive Telehealth at Syringe Service Programs to Engage People Who Inject Drugs into the HIV Care Continuum
PROJECT SUMMARY Biomedical breakthroughs over the past 30-years have dramatically improved treatment and prevention of HIV, hepatitis C virus (HCV), and opioid use disorder (OUD)....
A System Approach to Animal-Level Antimicrobial Use Monitoring in Dairy Cattle
PROJECT SUMMARY There is a fundamental gap in our ability to monitor antimicrobial use (AMU) at the individual animal level in dairy cattle nationally. The continued existence of t...
Antimicrobial Use Data Collection in the U.S. Poultry Production System
Project Summary/Abstract Antimicrobial use (AMU) is the primary selective force behind the emergence of resistant bacteria. Improving antimicrobial stewardship (AMS) in human and a...
Bridging Critical Data Gaps in Veterinary Medicine Via Artificial Intelligence and Advanced Large Language Models to Procure Real-Time Antibiotic Use Data in Livestock, Poultry and Companion Animals
Project Summary Antibiotic resistance stands as a formidable challenge in both human and veterinary medicine, demanding comprehensive strategies to monitor and regulate antimicrobi...
Phase 2 Study of Interferon-Gamma and Donor Lymphocyte Infusion for the Treatment of Relapsed Myeloid Malignancies after Allogeneic Stem Cell Transplantation
Project Summary/Abstract Allogeneic stem cell transplantation (alloSCT) is a potentially curative therapy for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Donor-...
Retinoblastoma Phase II Expanded Access Clinical Trial
Abstract Retinoblastoma (RB) is a micro-orphan disease intraocular cancer in infants and children (typically diagnosed between birth and 5-years of age). Approximately 250 new case...