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99,167 grants found
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Leveraging Consanguinity in Pakistan to Uncover the Genomic Architecture of Alzheimer's Disease: Feasibility Study with ENIGMA-PAK
PROJECT SUMMARY/ABSTRACT Currently, there are almost 55 million people living with dementia worldwide, and this number is estimated to double every 20-years, reaching about 131.5 m...
Dissecting the interaction between sex and APOE genotype in modulating AD risk
Although the majority of AD patients are sporadic (SAD), numerous studies have implicated biological sex and variation in the Apolipoprotein E (APOE) gene as two of the strongest f...
A friend in my pocket": mHealth intervention to reduce overdose risk among people who engage in polysubstance use
Polysubstance use is the defining characteristic of the fourth wave of the overdose (OD) epidemic. The proposed study will adapt and test a smartphone-based mobile health (mHealth)...
Dietary factors, neuroinflammation, plasma neurodegenerative biomarkers and Alzheimer’s disease in diverse cohorts
Project Summary N resubmission in response to PAR-22-093. Prevention strategies, such as healthy sustainable diets are critical and ase-related dementia (AD/ADRD) to have a populat...
Cellular senescence as a potential sex-specific driver of small vessel disease and post-stroke cognitive impairment in late adulthood
PROJECT SUMMARY/ABSTRACT Stroke is the leading cause of long-term disability in the United States and is the third leading cause of death in women, and the fifth in men. Through im...
Development and Evaluation of a Mobile Health Intervention for Co-Morbid Opioid Use Disorder and Posttraumatic Stress Disorder During Community Re-entry
PROJECT SUMMARY/ABSTRACT Of the nearly 400,000 people with an opioid use disorder (OUD) who receive OUD treatment each year, 1 in 6 utilize residential services. Community re-entry...
Race & Place: The Impacts of Racial Inequality on Substance Use and HIV Outcomes in Los Angeles
ABSTRACT It is well established that racial disparities in HIV care outcomes and use of substances among sexual minority men (SMM) of color persist because of structural racism in...
A Digital Toolkit to Address Intimate Partner Violence in Opioid Use Disorder
PROJECT SUMMARY/ABSTRACT Intimate partner violence (IPV), posttraumatic stress disorder (PTSD), and opioid use disorder (OUD) are highly co-occurring conditions. Up to 94% of indiv...
Antibody targeting of the virome
PROJECT ABSTRACT While the microbiota has emerged as an important aspect of mammalian health, the vast majority of current studies have focused on the bacterial component of the mi...
Cell Type-Specific Alternative polyadenylation of mRNA in Alzheimer's disease
Project summary Alzheimer’s disease (AD) is the most common, slowly progressing neurodegenerative disease, resulting in de- mentia and eventually death. More than six million Ameri...
Preoperative Risk Prediction of Postoperative Complications for Elective Cardiac Surgery using At-home Smartphone Dynamometry
Project Summary/Abstract Surgical complication represents one of the biggest factors impacting quality of care and is one of the major burdens on the healthcare system. There are 4...
Development of 1,4-Benzodioxane Derivatives as F-18 PET Radiotracers for Alpha-2C Adrenergic Receptors and Their Preclinical Evaluations
PROJECT SUMMARY Millions of middle-aged and seniors in the United States maintain their blood pressure and prevent cardiovascular emergencies by taking - and -blockers daily. The...
Alzheimer's Disease (AD) and Vascular Brain Injury- related changes in longitudinal Magnetic Resonance Imaging associated with Intraindividual Cognitive Variability in Aging American Indians.
Project Summary/ Abstract American Indians are at higher risk for Alzheimer’s disease and Alzheimer’s disease related dementia (AD/ADRD) compared to the general population, yet dem...
Rapid In Vivo Screening of Combination Gene Therapies for Axonal Regeneration after Spinal Cord Injury
Project Summary/Abstract (max: 30 line limit) Adult neurons in the central nervous system fail to regenerate after spinal cord injury (SCI). Large-scale screens performed in vitro...
Development of a novel intracellular targeting nanobody that blocks Cx43-mediated pathological proliferation
|| Project Summary This R21 is in response to FOA PA-20-195/ NOT-HL-21-024: development of new ideas and first-generation prototypes for therapeutics and nanotechnologies as applie...
Feasibility and reproducibility of hyperpolarized 13C pyruvate human brain imaging on a new MRI scanner platform
PROJECT SUMMARY / ABSTRACT Hyperpolarized (HP) 13C pyruvate MRI is an emerging imaging modality that provides unique access to glucose metabolism in the brain, a pathway that is im...
Non-invasive abdominal fetal electroencephalography for fetal assessment
ABSTRACT Every year in the United States, over 35,000 newborns suffer from neurologic injury at the time of birth due to hypoxia. Despite widespread use of cardiac external fetal m...
Long-term Effects of a household Air Pollution intervention: Follow-up of a randomized controlled trial
SUMMARY Project Title: Long-term Effects of a household Air Pollution intervention: Follow-up of a randomized controlled trial Globally, nearly 3 billion people are exposed to hous...
Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitis
PROJECT ABSTRACT Kawasaki disease (KD), an acute febrile illness and systemic vasculitis of unknown etiology, is the leading cause of acquired heart disease among children in the U...
Role of Epigenetic Regulator SIN3a in Pulmonary Endothelial Cells
PROJECT SUMMARY Pulmonary arterial hypertension (PAH), a deadly cardiopulmonary disease that develops following a genetic or environmental insult, is characterized by pulmonary end...