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Showing 1,0211,040 of 99,167 grants

Active NON-SBIR/STTR RPGS
Telehealth Use and the Quality of End-of-Life Care for Nursing Home Residents with Alzheimer's Disease and Alzheimer's Disease-Related Dementias
NATIONAL INSTITUTE ON AGING Weill Medical Coll of Cornell Univ United States 2024 – 2028

PROJECT SUMMARY/ABSTRACT Expanded Medicare coverage for telehealth services during the COVID-19 public health emergency (PHE) has removed many of the barriers to telehealth provisi...

$8.59M
USD
Active NON-SBIR/STTR RPGS
Customizable 3D Matrix to Investigate Glycan Function
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES University of Maine Orono United States 2024 – 2027

Customizable 3D Matrix to Investigate Glycan Function PI: Matthew Brichacek; Co-I: William Gramlich, University of Maine Abstract/Summary Glycans in the form of glycoproteins, prot...

$4.34M
USD
Active NON-SBIR/STTR RPGS
Multiscale modeling of fluidity in partial EMT (pEMT) planar tissues
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES Worcester Polytechnic Institute United States 2024 – 2028

20*2%. +2(&402 2+/&+1%- /6(34+*%402 %34 +234 +''-( Wu, Min ! # (( +/3425&4+0/3 To date, the studies on tissue fluidity are limited to the epithelial-tissue pa...

$3.05M
USD
Active NON-SBIR/STTR RPGS
Network-based study design, statistical, and modeling solutions for HIV among populations that use illicit substances: Informing interventions and policy in real-world settings using existing data
NATIONAL INSTITUTE ON DRUG ABUSE University of Rhode Island United States 2024 – 2029

Project Summary/Abstract Young black men who have sex with men (BMSM) experience a disproportionate burden of HIV infection despite advances in HIV treatment and prevention, and th...

$7.72M
USD
Active NON-SBIR/STTR RPGS
Social Media Use in Early Adolescence: Implications for Body Image
NATIONAL INSTITUTE OF MENTAL HEALTH University of North Carolina Chapel Hill United States 2024 – 2026

Project Summary The sharp increase in mental health symptoms among adolescents has triggered alarm regarding possible sources for this increase, with much public concern focused on...

$4.28M
USD
Active NON-SBIR/STTR RPGS
Behavioral Pharmacology of Opioid/Xylazine Mixtures
NATIONAL INSTITUTE ON DRUG ABUSE University of Texas Hlth Science Center United States 2024 – 2029

PROJECT SUMMARY The opioid crisis continues despite the availability of several FDA approved medications for treating opioid abuse and overdose. This public health crisis has worse...

$3.93M
USD
Active NON-SBIR/STTR RPGS
Subcellular Proteomics in Orbitostriatal Circuits in Incubation of Oxycodone Craving
NATIONAL INSTITUTE ON DRUG ABUSE University of Maryland, College Park United States 2024 – 2026

PROJECT SUMMARY/ABSTRACT Relapse after abstinence is a key challenge for curbing the ongoing opioid epidemic. One of the common factors for triggering relapse is re-exposure to dru...

$4.04M
USD
Active NON-SBIR/STTR RPGS
Development of selective degradation strategies towards mutant transcription factors
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Icahn School of Medicine At Mount Sinai United States 2024 – 2026

SUMMARY Transcription factors play essential roles in establishing the correct gene expression patterns unique to each cell type. These finely controlled patterns can fall apart if...

$2.54M
USD
Active NON-SBIR/STTR RPGS
Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals with Opioid Use Disorder and Chronic Pain
NATIONAL INSTITUTE ON DRUG ABUSE Duke University United States 2024 – 2027

Tobacco smoking, opioid use disorder, and chronic pain are highly comorbid conditions, and smoking cessation in this population is extremely difficult to achieve. Co-administration...

$2.42M
USD
Active NON-SBIR/STTR RPGS
Targeted ingression of SNPs into the zebrafish genome
OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEA... Iowa State University United States 2024 – 2026

Despite recent advances in gene editing, the ability to make small changes in the genomes of model organisms remains a challenge. In zebrafish, enhanced oligo design, base-editing...

$1.82M
USD
Active NON-SBIR/STTR RPGS
Novel zebrafish model of syndromic craniosynostosis
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEAR... Emory University United States 2024 – 2026

PROJECT SUMMARY To enable deformation of the skull during birth and allow for the rapid growth of the brain during early life stages, the bones of the skull roof are connected thro...

$3.13M
USD
Completed NON-SBIR/STTR RPGS
Earlier detection of HPV-related oropharynx cancer in people living with and without HIV
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEAR... Johns Hopkins University United States 2024 – 2025

Abstract Oral HPV is the cause of increasing incidence of HPV-related oropharynx cancer (HPV-OPC) in the United States and globally, and is expected to continue into the next centu...

$5.16M
USD
Active NON-SBIR/STTR RPGS
Adapting and evaluating smartphone app-enhanced home blood pressure monitoring among pregnant women in Ghana
FOGARTY INTERNATIONAL CENTER University of Michigan At Ann Arbor United States 2024 – 2026

Project Summary / Abstract Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality, particularly in LMICs. Home BP monitoring is an emerging str...

$1.93M
USD
Active NON-SBIR/STTR RPGS
Families left behind: Addressing prolonged grief and substance use disorders among people bereaved by drug overdose deaths
NATIONAL INSTITUTE ON DRUG ABUSE Stanford University United States 2024 – 2026

Our nation is experiencing historic rates of drug overdose deaths that has left behind millions of bereaved families. People who are bereaved by overdose experience a “special grie...

$12.99M
USD
Active NON-SBIR/STTR RPGS
Reversing Overdose Epidemics through Simulation, Collaboration, and Unified Efforts (RESCUE)
NATIONAL INSTITUTE ON DRUG ABUSE University of Minnesota United States 2024 – 2028

The US is currently grappling with an escalating drug overdose crisis, with overdose deaths soaring to a record high of 110,000 in 2022 alone. This crisis has particularly devastat...

$11.58M
USD
Active NON-SBIR/STTR RPGS
Enhancing Malaysian Workers' Safety and Health through Safety Culture and Climate mHealth Interventions
FOGARTY INTERNATIONAL CENTER Oregon Health & Science University United States 2024 – 2026

PROJECT SUMMARY Occupational injuries and workplace accidents still occur on a tremendous scale, despite researchers’ development of successful occupational safety and health inter...

$1.95M
USD
Active NON-SBIR/STTR RPGS
Developing An Empowerment Theory-Based Smoking Cessation Intervention for Sexual and/or Gender Minority People with Community Partners
NATIONAL INSTITUTE ON DRUG ABUSE University of Oklahoma Hlth Sciences Ctr United States 2024 – 2027

PROJECT SUMMARY/ABSTRACT This multi-phased, community-engaged R34 proposal was developed with community partners to (1) inform, (2) develop, and (3) pilot test protocol for ECHO (E...

$1.91M
USD
Active NON-SBIR/STTR RPGS
Adapting mHealth to improve HIV outcomes among older people with HIV in Ukraine
FOGARTY INTERNATIONAL CENTER Yale University United States 2024 – 2026

ABSTRACT Among the 5.5 million older people (>50-years) with HIV (OPWH), 80% live in low- and middle-income countries (LMIC). Ukraine, an emblematic LMIC in Eastern Europe and C...

$2.16M
USD
Active NON-SBIR/STTR RPGS
Using adaptive e-learning and smartphones to improve newborn and pediatric admission care outcomes in Mwanza, Tanzania
FOGARTY INTERNATIONAL CENTER Stanford University United States 2024 – 2026

Project Summary/Abstract: In sub-Saharan Africa, low quality care at health facilities contributes to over 1 million child deaths each year. Provider knowledge is a major contribut...

$1.75M
USD
Active NON-SBIR/STTR RPGS
SCH: Visual explanation-guided learning for human-AI collaborative abdominal cancer diagnostic imaging
NATIONAL CANCER INSTITUTE Emory University United States 2024 – 2028

PROJECT SUMMARY (See instructions): Early detection of abdominal cancers is notoriously challenging. Symptoms are often unclear, and tumors are located deep inside the body, making...

$2.91M
USD