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Understanding dynamics of brain network in TDP-43 related neurodegeneration
Mislocalization of TDP-43 is a common pathological feature of several neurodegenerative diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, and frontotemporal d...
Proof of concept and feasibility in humans for pulsed ultrasound treatment to reduce inflammation and risk of AKI
Abstract This clinical study proposal is being submitted in response to PAS-20-160 "Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK, which does n...
Explicating Vulnerability and Resilience in Opioid Self-Administration in Middle Aged Rats
Mortality statistics in the United States show a steady increase in deaths due to prescription opioids over the past two decades, accompanied by a steep increase in heroin-related...
Molecular and morphometric imaging of coagulation and inflammation in pulmonary embolism pathogenesis
PROJECT SUMMARY Pulmonary Embolism (PE) urgently requires improved diagnostic and therapeutic strategies to minimize both acute complications resulting in hemodynamic shock and lat...
Effect of infant antibiotics on the development of the early-life airway and gut microbiome and risk of childhood asthma
PROJECT SUMMARY The use of antibiotics in the first year of life has been recognized as a strong, consistent, and modifiable risk factor for the development of asthma in childhood...
Dynamic imaging of lung function in free-breathing subjects
SUMMARY Hyperpolarized 129Xe MRI of the lung with polarized gases is capable of providing valuable regional information about ventilation and gas exchange that is unobtainable usin...
Intestine to adipose tissue interorgan communication in homeostasis and obesity
PROJECT SUMMARY Secreted proteins coordinate organ functions during homeostasis. The secreted proteome represents a poorly- characterized interorgan communication network, which is...
Function and mechanism of EndoU
PROJECT SUMMARY RNA-binding proteins (RBPs), including enzymes that act on RNA, impact all aspects of cellular function. However, the roles, molecular mechanisms and integration wi...
Illuminating early microglial dysfunction in Alzheimer's disease through integration of explainable AI and iPSC models
Alzheimer Disease (AD) pathogenesis is multifactorial involving multiple cell types which offers several points of intervention. Microglia, the innate immune cell of the brain, are...
Potential of Dried Blood Spots for Measurement of Alzheimer's Disease Biomarkers
PROJECT SUMMARY/ABSTRACT The rapid development of ultrasensitive immunoassays has made it possible to measure biomarkers for Alzheimer’s disease (AD) in blood with high accuracy, a...
Impaired cellular RNA editing as a cause of inflammation in inflammatory bowel disease
PROJECT SUMMARY AND ABSTRACT: The etiology of inflammatory bowel disease (IBD), defined as Crohn's disease (CD) or ulcerative colitis (UC), remains elusive. Although genetic s...
Efficacy and implementation considerations for a peer-led motivational interviewing intervention to promote uptake of drug checking services and safer drug use behaviors to reduce overdose
We will conduct a hybrid type 1 study to evaluate efficacy and preliminary implementation considerations for a novel intervention to promote uptake of drug checking services (DCS)...
Bio-RaPID: Biomarkers and Rates of Progression In Dementia.
PROJECT SUMMARY Patients with rapidly progressive dementia (RPD) experience accelerated declines in cognition resulting in dementia within 1-year or complete incapacitation within...
Impact of SARS-Cov-2 on a Rat Model Cerebral Amyloid Angiopathy
Although the pandemic phase of SARS-CoV-2 infections has diminished the disease remains highly endemic in the US population with current weekly hospitalizations from infection rema...
Impact of change in lifestyle health behaviors on cognition: Harmonizing and leveraging participant-level data from randomized controlled trials
Lifestyle health behaviors, such as physical activity, cognitive activity, healthy diet, and social activity, are low- risk, non-pharmaceutical strategies that may help protect aga...
Testing sex as a moderator of health impacts of upward mobility on indicators for AD risk in young adulthood
Abstract Early poverty and lower education attainment are associated with increased rates of Alzheimer's Disease (AD), and lower cognitive functioning in later adulthood. Upwa...
A Mouse Model for Braak I/II Alzheimer's Pathology
ABSTRACT: The goal of this study is to characterize a novel mouse mutant with a phenotype resembling Braak stage I/II Alzheimer’s disease (AD) pathology in humans and to develop th...
A Mechanistic Foundation for the Iron Homeostasis Impacts and Neurotrophic Activity of trans-Banglene
Project Summary/Abstract Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease, constitute one of the greatest challenges in modern therapeutic d...
Gut microbiome-related metabolites and cognitive impairment
Abstract Cognitive impairment is a significant source of neurological disability, and a majority of cases are caused by vascular contributions to cognitive impairment and dementia...
Identifying Undiagnosed Alzheimer’s Disease in Understudied Populations
Project Abstract Diagnosis of Alzheimer’s disease (AD) is crucial for individuals to pursue treatments and plan for the future. Unfortunately, AD is underdiagnosed in community set...