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Aberrant protein S-nitrosylation mediates Gene-Environment Interactions in AD/ADRD
Project Summary Alzheimer’s disease (AD) and AD-related dementias (ADRD) represent the most common forms of neurodegenerative disease in patients above 65-years of age. Growing evi...
Phase II trial of avutometinib plus defactinib in RAF dimer-driven thyroid cancers
ABSTRACT/SUMMARY Two rare types of thyroid cancer currently have extremely poor outcomes. Radioiodine-refractory (RAIR), recurrent and/or metastatic (R/M) differentiated thyroid ca...
Gene Therapy for LCA5-Assocated Inherited Retinal Degeneration: Extension to Pediatric Cohorts
PROJECT SUMMARY / ABSTRACT Advances in genetics and genomics have raised hopes for the development of gene-based treatments for inherited retinal diseases (IRDs) which are single-g...
Disturbed sleep and atherosclerosis
Summary Atherosclerosis is the major etiological process responsible for 25% of global deaths. Numerous reports indicate both the adaptive and innate immune systems are involved in...
Developmental and Serotonin 5-HT2A Receptor Effects on Fentanyl Reinforcer Value
PROJECT SUMMARY Adverse childhood experiences (ACEs), chronic stress, and isolation increase the odds of misusing opioids. In treatment-seeking people with opioid use disorder, exp...
Examination of Xylazine Exposure and the Risk of Skin and Soft Tissue Infections in People Who Inject Drugs
Summary Alterations in the availability, potency, or composition of illicit drugs can lead to shifts in drug use behaviors and drug-related morbidity and mortality. Such changes ca...
Prevalence and Impact of frailty in older adults with polymyalgia rheumatica
ABSTRACT Polymyalgia rheumatica (PMR) is the most common systemic rheumatic disease affecting older adults. Despite this, PMR remains critically understudied. One in three individu...
Social Determinants of Health, Asthma-Related Morbidity and Therapeutic Optimization for Black and Latinx Adults with Asthma
Summary: Asthma is a common chronic airway disease that affects 21 million adults in the US with substantial morbidity and healthcare costs. Black and Latinx adults bear a dispropo...
Improving decision-making for older adults with melanoma
PROJECT SUMMARY/ABSTRACT: Older adults account for over half of new cases of melanoma each year, but healthcare providers face significant challenges when deciding on appropriate t...
Characterizing the impact of presbyphonia on social interaction
PROJECT SUMMARY/ABSTRACT Approximately 20% of older adults in the United States have a voice disorder. One of the most common voice disorders in older adults is presbyphonia, relat...
The Impact of Forced Displacement on Aging Adult Mental Health: Implications for Developing Interventions
Abstract In the US, there are 7.3 million older adult immigrants (inclusive of refugees), and by 2060 the US’s older adult immigrant population is anticipated to increase to 22 mil...
Cost and Non-Cost Barriers to Use of Novel AD Therapeutics among Older Hispanic or Latino Adults
Project Summary The goal of this project is to assess the role of cost-associated barriers to new and future novel AD/ADRD therapeutics in Hispanic or Latino older adults. Our work...
Biomarker-Guided Antidepressant Selection for Treatment-Resistant Depression
Major depressive disorder is a leading cause of disability. Two FDA-approved treatments—and ketamine and accelerated repetitive transcranial magnetic stimulation targeting the left...
A Mobile Health Behavior Intervention to Reduce Pain and Improve Health-III (MORPH-III)
PROJECT SUMMARY As many as three in four older adults live with chronic pain; a debilitating condition that affects quality of life and independence. Unfortunately, chronic pain bo...
Metabolic regulation of myocardial perfusion in the aging heart
PROJECT SUMMARY Advanced age is the leading risk factor for all chronic diseases. It is associated with a host of genetic, immunologic, and physiologic changes that contribute to p...
The circadian clock as an age sensor in asthma resolution
ABSTRACT We propose to study how the innate response to virus changes as children mature, which we theorize contributes to asthma remission. Although asthma is a chronic disease, i...
Molecular and Cellular Profiling of the Habenulointerpeduncular Circuit in Opioid Tolerance and Withdrawal
ABSTRACT The present crisis of opioid addiction in the United States highlights how an initial exposure to opioids, often oxycodone, as a medical patient can lead to escalation of...
Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately compromise healthspan and quality of life (QoL). Exercise is a multipote...
A2: Striosomal models of drug use and cost
Project Summary Our understanding of the mechanistic underpinnings of drug consumption and craving has been greatly aided by the development of numerous computational models focuse...
ASPIRE to Change: Leveraging Text Messaging Peer Support Coaching to Mitigate Hazardous Alcohol Consumption in Non-Collegiate Young Adults
PROJECT SUMMARY / ABSTRACT Hazardous alcohol consumption remains a significant public health issue among U.S. young adults aged 18 to 25. While interventions exist for college stud...