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99,167 grants found
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Mechanisms of Reverse Transendothelial Migration in Arthritis Resolution
3. Abstract Inflammation is a beneficial response to infection or tissue damage and mediates the removal of microbial pathogens and restoration of the tissue to homeostasis. Occasi...
Gait as a Preclinical Marker for Alzheimer’s Disease and Dementia: insights from super-movers, usual-movers, and slow-movers
Emerging research implicates gait dysfunction as a preclinical marker of Alzheimer’s disease and related dementias. Our team has been in the vanguard of gait and cognition research...
Neural mechanisms of gait disturbances as individualized digital biomarker trajectories in preclinical dementia
PROJECT SUMMARY Alzheimer's disease and related dementias (AD/ADRD) rank prominently among age-associated neurodegenerative disorders, with Parkinson’s disease trailing as the...
Diagnostic identification of language and reading disorders among bilingual learners
A major problem in research and practice is that bilingual students in the U.S. are often misidentified having language and reading disorders. Both over- and under-diagnosis of dis...
Understanding and Visualizing Emergency Department Clinician Well-Being and Strain
Project Summary Emergency department clinicians (ECs) regularly experience among the highest rates of psychological distress. Manifesting in poor well-being and burnout, EC psychol...
Functional Genomics of Multiple Hereditary Exostoses
Multiple hereditary exostoses (MHE) is an autosomal dominant disorder that affects one in every 50,000 children worldwide and is characterized by the formation of cartilage-capped...
Statistical Methods for Characterizing Molecular Mechanisms of Human Tissue Development and Disease
Project Summary The unique biospecimens and data from the Developmental GTEx (dGTEx) project create an exciting opportunity and need for novel methods development. In this project,...
Population-Based Outcomes Research for Rheumatoid Arthritis: Rural Health Disparities
PROJECT SUMMARY/ABSTRACT In rheumatoid arthritis (RA), delaying initiation of treatment for ≥12 weeks is associated with irreversible joint damage due to greater difficulty in achi...
Novel data and approaches for dynamic modeling of human behavior and infectious disease ecology
PROJECT SUMMARY Demographic and social forces that influence human behavior fundamentally shape the epidemiology of infectious diseases, but are often left out from mathematical mo...
VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD
Understanding the pathogenesis of cerebral small vessel disease (CSVD) and vascular contributions to dementia (VCID) is increasingly important to help protect the cognitive and men...
oREgon medicaid policy, SOciaL serVices, and hEalth (RESOLVE)
Project Abstract The circumstances in which people are born, grow, live, and work—often referred to as social determinants of health (SDH)—have well-documented impacts on chronic d...
Brain capillary endothelial cell energetics and neurovascular uncoupling in dementia
Growing evidence suggests the contribution of altered brain microcirculation to cognitive impairment and dementia observed in Alzheimer's disease (AD) and AD-related dementia...
From Impairment to Participation: A Systems Approach to Understanding the Complexity of Aphasia
Project Summary Language is vital to much, if not all, aspects of a person’s life. For those persons with aphasia (PWA), a language disorder, the impact of aphasia extends beyond t...
Attention Regulation Strategies Used by Deaf and Hearing Parents of Autistic Children
PROJECT SUMMARY Difficulties with social communication are among the core impairments of autism spectrum disorders (ASD) and pose significant challenges for the one in 44 American...
Systematic Functional Genomics Analysis of the Oral Pathogen Streptococcus Mutans
Project Summary In this project we will construct a powerful new tool to systematically identify infection-relevant genes in the dental caries pathogen Streptococcus mutans. Sequen...
The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal Reflux
PROJECT ABSTRACT Among the 20% of US adults experiencing laryngeal symptoms, 80% are diagnosed with laryngopharyngeal reflux (LPR) based on symptoms alone and empirically treated w...
Transcranial stimulation combined with auditory training
Project Summary/Abstract The goal of this project is to investigate the potential of transcranial stimulation to enhance intelligibility in speech mixtures in older adults struggli...
Effects of Aphasia Identification Cards on Comprehension of Aphasic Language by Unfamiliar Communication Partners.
Project Summary/Abstract People with aphasia often experience challenges conveying their thoughts to unfamiliar communication partners, which is critical for living independently a...
Mechanistic underpinnings of pragmatics in ASD: Insights from FMR1-mutation conditions
Project Summary Impaired pragmatic (i.e., social) language is a defining symptom domain of autism spectrum disorder (ASD) and imposes significant burden on affected individuals and...
An innovative approach to cracking odor coding in the piriform cortex
Project SummaryAs the largest cortical recipient of direct olfactory bulb (OB) projections and a prominent part of the rodent brain, the piriform cortex (PCx) is considered to be a...