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99,167 grants found
Showing 81 – 100 of 99,167 grants
Adult Changes in Thought (ACT) Research Program
The Adult Changes in Thought (ACT) U19 Program will expand, modernize, and improve ACT's prospective cohort study to achieve advances in scientific understanding of older adults i...
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies
ABSTRACT: Cognition Therapeutics, Inc. (CogRx) is developing CT1812 for neurodegenerative conditions, including Dementia with Lewy Bodies (DLB). This first-in-class small molecule...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population....
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortex
PROJECT SUMMARY In this proposal we aim to identify gene regulatory elements that permit the targeting and manipulation of brain circuit models of human brain function. Gaining g...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population....
Design and Development of a Pan-betacoronavirus Vaccine
Abstract - Overall Compared to SARS-CoV-1 and MERS, the current SARS-CoV-2 virus is highly transmissible and to date has caused over 85,000,000cases worldwidewith over 1,800,000...
Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Scientific Leadership Center
Adolescents and young adults (AYA) under the age of 25 in the United States (US) are the least likely of all age groups to: 1) know their HIV status, 2) initiate PrEP if HIV-negat...
ED-LEAD: Emergency Departments LEading the transformation of Alzheimer's and Dementia care
PROJECT SUMMARY In persons living with dementia (PLWD), an Emergency Department (ED) visit is a critical event and an opportunity to address the unmet needs that preceded the vis...
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies
ABSTRACT: Cognition Therapeutics, Inc. (CogRx) is developing CT1812 for neurodegenerative conditions, including Dementia with Lewy Bodies (DLB). This first-in-class small molecule...
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)
ABSTRACT The goal of this proposal is to create a resource for studying the genetic etiology of Alzheimer disease (AD) in understudied and underserved populations. Alzheimer dise...
Michigan Institute for Clinical and Health Research (MICHR)
Project Summary/Abstract The Michigan Institute for Clinical & Health Research (MICHR) catalyzes clinical and translational research (CTR) and advances clinical and translational...
Michigan Institute for Clinical and Health Research (MICHR)
Project Summary/Abstract The Michigan Institute for Clinical & Health Research (MICHR) catalyzes clinical and translational research (CTR) and advances clinical and translational...
An Intermediate-Size Expanded Access Protocol for Amyotrophic Lateral Sclerosis with Pridopidine
The Sigma 1 Receptor (S1R) has emerged as an attractive therapeutic target in ALS. Mutations in the S1R are causative of ALS and the degree of loss of function in S1R protein det...
Novel Insights into Osteoarthritis, Pain and Function: MOST4
OVERALL ABSTRACT The Multicenter Osteoarthritis (MOST) Study has been a major source of new knowledge about the course of OA and factors that affect it, having published over 180...
Stanford Center for Clinical and Translational Research and Education
ABSTRACT The mission of the Stanford CTSA is to transform clinical, translational, and science of translation research and education (CTSRE) at Stanford and across the CTSA cons...
North Carolina Translational and Clinical Sciences Institute (NC TraCS)
Project Summary The North Carolina Translational and Clinical Sciences Institute (TraCS) is a dynamic regional network of universities, research institutes, healthcare providers,...
AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections
Project Summary The AIDS Clinical Trials Group (ACTG) has been at the forefront of clinical research to advance HIV therapeutics and improve the health of people living with HIV/...
A People-Centered, Technology-Driven, Scientific Approach to Advancing Conformance with the Voluntary National Retail Food Regulatory Program Standards
PROJECT SUMMARY After decades of incremental changes to the food safety system, technological advancements have ushered in a corresponding period of increased change for both food...
A People-Centered, Technology-Driven, Scientific Approach to Advancing Conformance with the Voluntary National Retail Food Regulatory Program Standards
PROJECT SUMMARY After decades of incremental changes to the food safety system, technological advancements have ushered in a corresponding period of increased change for both foo...
Wisconsin Registry for Alzheimer's Prevention
PROJECT SUMMARY The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is a longitudinal study that follows a risk-enriched cohort from late-midlife into old age and focuses on...