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Activity-Dependent Mechanisms of Memory Consolidation
PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learning...
Model Based Deep Learning Framework for Ultra-High Resolution Multi-Contrast MRI
Sensitive imaging biomarkers are urgently needed for screening of high‐risk subjects, determine early disease progression, and assess response to therapies in neurodegenerative dis...
Mitochondrial pyruvate transport in retinal health and disease
PROJECT SUMMARY/ABSTRACT The retina is the most metabolically active neuronal tissue in the human body. The defect in the energy metabolism of photoreceptor neurons and their suppo...
Senescent Vascular Cells as Mediators of Cognitive Decline
PROJECT SUMMARY The goals of this proposal are to (1) obtain experimental skills and career training necessary to develop an independent research program investigating mechanisms o...
Novel Nutrient Functions and Sensing Mechanisms
Project Summary/Abstract Despite its long history, the nutrient biology field is still facing a plethora of outstanding questions closely related to human health, two of which will...
Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representations
Although neuroscience has recently provided a great deal of information about how neurons represent and encode behaviorally relevant information at the population level, the fundam...
Dissecting and reconstructing the molecular roadmaps of cellular reprogramming to iPSCs in single-cell resolution
Project Summary Understanding the molecular programs that guide cell fate conversion will provide a foundation for the development of tools to convert cell fate and eventually faci...