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99,167 grants found
Showing 99,121 – 99,140 of 99,167 grants
Administrative Core
CORE SUMMARY / ABSTRACT The Administrative Core will manage the budgetary, administrative, and communication aspects of this Program. The Core will be responsible for coordinatin...
Core A: Elucidating the Mechanisms Underlying Mixed-Chimerism Based Tolerance
CORE SUMMARY / ABSTRACT Tolerance of kidney allografts has been achieved in monkeys and patients via transient mixed hematopoietic chimerism. However, until now, our current mixe...
Project 1: Augmenting Regulatory Mechanisms in Protocols of Transient Mixed Chimerism
PROJECT SUMMARY / ABSTRACT Induction of immune tolerance is the ultimate goal in the field of organ transplantation. Achieving a state of tolerance would lead to indefinite graft...
Project 2: Next-Generation Mixed Chimerism Induction for Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT Heart transplantation represents the best therapeutic option for patients with end-stage cardiac disease. However, while one-year success rates are rea...
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT The unifying goal of this Program is to design new and innovative strategies that achieve clinically-relevant heart allograft tolerance in 2-month-dela...
Administrative Core (Core A)
ABSTRACT – CORE A The Administrative Core (Core A) will be the central hub of our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Outreach (E...
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
ABSTRACT – PROJECT 1 Endometriosis is a chronic, estrogen-dependent, inflammatory disease that affects ~10% of reproductive age women, resulting in debilitating pelvic pain, infe...
Administrative Core
PROJECT SUMMARY/ABSTRACT Administrative Core The administrative core will oversee the coordination of the Program as a whole. Specifically, it will be in charge of supervising t...
Research Bronchoscopy and Biospecimens Core
PROJECT SUMMARY/ABSTRACT Core B: Bronchoscopy and Biospecimens The goal of this core is four-fold. First, the core is responsible for performing bronchoscopy on study subjects t...
Severe Asthma Clinical Studies Core
PROJECT SUMMARY/ABSTRACT Core C The Clinical Studies Core is an integral component of the PPG as it is designed to facilitate the conduct of clinical trials outlined in the thre...
Primary Human Airway Cell Culture Core
PROJECT SUMMARY/ABSTRACT Core D Cell Culture The goal of the work described in this proposal is to collect grow, store and expand airway epithelial cells and smooth muscle cells...
Preventing Chronic Post-Surgical Pain and Prolonged Opioid Use: The Perioperative Pain Self-Management Program
Background: Surgery can precipitate the development of both chronic pain and long-term opioid use. Preoperative psychological distress is a risk factor for poor post-surgical outc...
Project 1: Elucidating the genetics and cell of origin of pancreatic cancer initiation
ABSTRACT (Project 1) Pancreatic ductal adenocarcinoma (PDAC) is a prevalent and almost uniformly fatal malignancy. Human PDAC genome sequencing has identified recurrent mutations...
Project 2: Immune signals promoting pancreas cancer stemness and progression
ABSTRACT (Project 2) There is an urgent need to discover improved therapies for pancreatic ductal adenocarcinoma (PDAC), which require a better understanding of mechanisms unde...
Project 3: Impact of tumor genetics on PDAC immunobiology and responses to macrophage-targeted immunotherapy
ABSTRACT (Project 3) Pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy that is poorly responsive to treatment, is characterized by a prominent infiltration of imm...
Administrative and Biostatistics Core
ABSTRACT (Core A-Administrative and Biostatistics Core) This application seeks support for its efforts to discover, apply, and translate scientific knowledge about pancreatic c...
Core B: Human Pancreas
ABSTRACT: Stanford Human Bio-bank for Pancreas Cancer Research (Core B) The Stanford Human Bio-Bank for Pancreas Cancer Research (Core B) will support human tissue and cell stud...
Core C: CODEX Core
ABSTRACT (Core C) A central focus of our program is understanding the roles of specific cell types, including immune cell populations, throughout the initiation, development and...
Administrative Core for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: ADMINISTRATIVE CORE The overarching goal of the Administrative Core is to provide the operational support necessary to successfully achieve the goals we have laid out f...
Data Management and Analysis Core (DMAC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: DATA MANAGEMENT AND ANALYTICS CORE (DMAC) Data Management and Analytics Core (DMAC) and the overall goals that provide support to the Scientific Human Biomarker Exposur...