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99,167 grants found
Showing 99,101 – 99,120 of 99,167 grants
Project 1: Elucidating the genetics and cell of origin of pancreatic cancer initiation
ABSTRACT (Project 1) Pancreatic ductal adenocarcinoma (PDAC) is a prevalent and almost uniformly fatal malignancy. Human PDAC genome sequencing has identified recurrent mutations...
Project 2: Immune signals promoting pancreas cancer stemness and progression
ABSTRACT (Project 2) There is an urgent need to discover improved therapies for pancreatic ductal adenocarcinoma (PDAC), which require a better understanding of mechanisms unde...
Project 3: Impact of tumor genetics on PDAC immunobiology and responses to macrophage-targeted immunotherapy
ABSTRACT (Project 3) Pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy that is poorly responsive to treatment, is characterized by a prominent infiltration of imm...
Administrative and Biostatistics Core
ABSTRACT (Core A-Administrative and Biostatistics Core) This application seeks support for its efforts to discover, apply, and translate scientific knowledge about pancreatic c...
Core B: Human Pancreas
ABSTRACT: Stanford Human Bio-bank for Pancreas Cancer Research (Core B) The Stanford Human Bio-Bank for Pancreas Cancer Research (Core B) will support human tissue and cell stud...
Core C: CODEX Core
ABSTRACT (Core C) A central focus of our program is understanding the roles of specific cell types, including immune cell populations, throughout the initiation, development and...
Preventing Chronic Post-Surgical Pain and Prolonged Opioid Use: The Perioperative Pain Self-Management Program
Background: Surgery can precipitate the development of both chronic pain and long-term opioid use. Preoperative psychological distress is a risk factor for poor post-surgical outc...
An Assessment of Open Access Audio of the Clinical Encounter on Veterans and their Care
Background: The medical encounter can be overwhelming in term of the amount of information discussed, its technical nature, and the anxiety it can generate. Easy access to a secur...
Genetics & Clinical Cohorts
To achieve a 95% reduction of TB deaths by 2035 the WHO END-TB strategy states that critical introduction of new tools, such as a vaccine, drugs and treatment regimes, and a point...
Systems Biology, Bioinformatics, & Data Integration
Genome-wide research strategies provide unprecedented opportunities for insight but also major bioinformatic challenges due to the size and complexity of the data. The multidiscip...
M. tuberculosis strain-dependent interactions with host cells
Tuberculosis (TB) is a multifaceted disease that has extensive variation in clinical manifestations despite being the product of infection with a single pathogen, Mycobacterium tu...
Human macrophage variation & TB pathogenesis
Variation in clinical outcomes after Mtb exposure ranges from resistance to infection to disseminated disease. Human genetic and cellular mechanisms of resistance and disseminatio...
Mtb strain-dependent mechanisms of pathogenesis in mouse models
Tuberculosis (TB) is a highly heterogeneous human disease that develops in some, but not all, individuals who inhale 1-3 infectious bacilli of Mycobacterium tuberculosis (Mtb). TB...
Administrative Core
ADMINISTRATIVE CORE: ABSTRACT Natives Engaged in Alzheimer’s Research (NEAR) will be organized into an Administrative Core, a Recruitment and Engagement Core, a Biospecimen Core,...
Research Methods Core
RESEARCH METHODS CORE: ABSTRACT Healthy People 2020 calls for research and policy to eliminate racial and ethnic disparities in health status, health behaviors, functional limita...
Recruitment and Engagement Core
RECRUITMENT AND ENGAGEMENT CORE: ABSTRACT Many American Indian, Alaska Native (AI/AN), and Native Hawaiian and Pacific Islander (NHPI) communities view academic research with ske...
Biospecimen Core
BIOSPECIMEN CORE: ABSTRACT American Indians and Alaskan Natives (AI/ANs) and Native Hawaiians and Pacific Islanders (NHPIs) are subject to disparities in many health conditions,...
Indian Transforming Alzheimer's Care Training
RESEARCH PROJECT 1: ABSTRACT The American Indian and Alaska Native (AI/AN) population is growing 3 times faster than the US all-races population. The number of AI/ANs aged 65+ is...
IKE Kapuna (Elder Wisdom) Project
RESEARCH PROJECT 2: ABSTRACT The prevalence of Alzheimer’s disease and related dementias (ADRD) is rising in Hawai`i, where it is projected that 10% of people aged 65+ will be di...
Cognition After OSA Treatment Among Native American People
RESEARCH PROJECT 3: ABSTRACT Prevalence of obstructive sleep apnea (OSA) among older adults in the US is as high as 56%. Short-term neurological consequences of OSA include cogni...