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99,167 grants found
Showing 99,081 – 99,100 of 99,167 grants
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
ABSTRACT – PROJECT 1 Endometriosis is a chronic, estrogen-dependent, inflammatory disease that affects ~10% of reproductive age women, resulting in debilitating pelvic pain, infe...
Mass Spectrometry-based Global Molecular Approaches and Computational Tools to Determine Phenotypic and Environmental Signatures of Endometriosis
ABSTRACT – PROJECT 2 Approximately 10% of reproductive-aged women are diagnosed with endometriosis, an inflammatory, estrogen- dependent disorder characterized by endometrial tis...
Leveraging Omics-Based Computational Approaches to Identify and Validate Novel Therapeutic Candidates for Endometriosis
ABSTRACT – PROJECT 3 Endometriosis is a common, estrogen-dependent, inflammatory disorder that causes debilitating chronic pelvic pain including severe dysmenorrhea and dyspareun...
Education and Community Engagement Core (Core B)
ABSTRACT – CORE B The goal of the Educational Outreach Core (Core B) in our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (ENACT...
Severe Asthma Clinical Studies Core
PROJECT SUMMARY/ABSTRACT Core C The Clinical Studies Core is an integral component of the PPG as it is designed to facilitate the conduct of clinical trials outlined in the thre...
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT The unifying goal of this Program is to design new and innovative strategies that achieve clinically-relevant heart allograft tolerance in 2-month-dela...
Pulmonary Biostatistics Core
PROJECT SUMMARY/ABSTRACT Core E The Core will provide severe asthma investigators from each of the three Projects all facets of statistical support, including experimental desig...
S-nitrosylation signaling in asthma
PROJECT SUMMARY/ABSTRACT Project 1 Asthma afflicts over 7% of Americans and is the result of chronic inflammation of the airways leading to airway remodeling and hyperresponsive...
Airway pH regulation in asthma
PROJECT SUMMARY/ABSTRACT Project 2 The airway epithelium, like the renal tubular epithelium, expresses proteins that regulate luminal pH. For example, glutaminase regulates ammo...
Androgen signaling in asthma
PROJECT SUMMARY/ABSTRACT Asthma is a sexually dimorphic disease, with women exhibiting higher asthma prevalence and more severe manifestations than men. Projects 3 builds upon th...
Administrative Core for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: ADMINISTRATIVE CORE The overarching goal of the Administrative Core is to provide the operational support necessary to successfully achieve the goals we have laid out f...
Data Management and Analysis Core (DMAC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: DATA MANAGEMENT AND ANALYTICS CORE (DMAC) Data Management and Analytics Core (DMAC) and the overall goals that provide support to the Scientific Human Biomarker Exposur...
Project 1 for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: PROJECT 1 Air pollution, particularly particulate matter <2.5µm (PM2.5) comprising a variety of organic molecules produced by combustion, is a significant driver of chr...
Identifying Multidimensional Omics Profiles Associated with Cardiovascular and Pulmonary Responses to Chronic and Acute Air Pollution Exposure (Project 2) for AIRHEALTH Study
ABSTRACT: PROJECT 2 Lung and cardiac diseases are complex disorders with underlying chronic inflammation, which can be induced or worsened by exposure to air pollution. Thus, und...
Modeling Cardiovascular Risks of Air Pollutants with Human Induced Pluripotent Stem Cell-Derived Cardiovascular-Associated Cells (Project 3) for the Air pollution disrupts Inflammasome Regulation in
ABSTRACT: PROJECT 3 Air pollution, particularly particulate matter <2.5µm (PM2.5), penetrates into lung passageways and enters the bloodstream, causing respiratory, cardiovascula...
Administrative Core (Core A)
ABSTRACT – CORE A The Administrative Core (Core A) will be the central hub of our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Outreach (E...
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
ABSTRACT – PROJECT 1 Endometriosis is a chronic, estrogen-dependent, inflammatory disease that affects ~10% of reproductive age women, resulting in debilitating pelvic pain, infe...
Mass Spectrometry-based Global Molecular Approaches and Computational Tools to Determine Phenotypic and Environmental Signatures of Endometriosis
ABSTRACT – PROJECT 2 Approximately 10% of reproductive-aged women are diagnosed with endometriosis, an inflammatory, estrogen- dependent disorder characterized by endometrial tis...
Leveraging Omics-Based Computational Approaches to Identify and Validate Novel Therapeutic Candidates for Endometriosis
ABSTRACT – PROJECT 3 Endometriosis is a common, estrogen-dependent, inflammatory disorder that causes debilitating chronic pelvic pain including severe dysmenorrhea and dyspareun...
Education and Community Engagement Core (Core B)
ABSTRACT – CORE B The goal of the Educational Outreach Core (Core B) in our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (ENACT...