Browse All Grants
99,167 grants found
Showing 99,041 – 99,060 of 99,167 grants
Identifying Multidimensional Omics Profiles Associated with Cardiovascular and Pulmonary Responses to Chronic and Acute Air Pollution Exposure (Project 2) for AIRHEALTH Study
ABSTRACT: PROJECT 2 Lung and cardiac diseases are complex disorders with underlying chronic inflammation, which can be induced or worsened by exposure to air pollution. Thus, und...
Modeling Cardiovascular Risks of Air Pollutants with Human Induced Pluripotent Stem Cell-Derived Cardiovascular-Associated Cells (Project 3) for the Air pollution disrupts Inflammasome Regulation in
ABSTRACT: PROJECT 3 Air pollution, particularly particulate matter <2.5µm (PM2.5), penetrates into lung passageways and enters the bloodstream, causing respiratory, cardiovascula...
An Assessment of Open Access Audio of the Clinical Encounter on Veterans and their Care
Background: The medical encounter can be overwhelming in term of the amount of information discussed, its technical nature, and the anxiety it can generate. Easy access to a secur...
Administrative Core
Abstract The primary goal of the Administrative Core (Core C) is to support and promote the program and data management goals of this TBRU. Amongst its responsibilities, Core C w...
Mass Spectrometry-based Global Molecular Approaches and Computational Tools to Determine Phenotypic and Environmental Signatures of Endometriosis
ABSTRACT – PROJECT 2 Approximately 10% of reproductive-aged women are diagnosed with endometriosis, an inflammatory, estrogen- dependent disorder characterized by endometrial tis...
Leveraging Omics-Based Computational Approaches to Identify and Validate Novel Therapeutic Candidates for Endometriosis
ABSTRACT – PROJECT 3 Endometriosis is a common, estrogen-dependent, inflammatory disorder that causes debilitating chronic pelvic pain including severe dysmenorrhea and dyspareun...
Education and Community Engagement Core (Core B)
ABSTRACT – CORE B The goal of the Educational Outreach Core (Core B) in our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (ENACT...
Administrative Core
Abstract The primary goal of the Administrative Core (Core C) is to support and promote the program and data management goals of this TBRU. Amongst its responsibilities, Core C w...
Genetics & Clinical Cohorts
To achieve a 95% reduction of TB deaths by 2035 the WHO END-TB strategy states that critical introduction of new tools, such as a vaccine, drugs and treatment regimes, and a point...
Systems Biology, Bioinformatics, & Data Integration
Genome-wide research strategies provide unprecedented opportunities for insight but also major bioinformatic challenges due to the size and complexity of the data. The multidiscip...
M. tuberculosis strain-dependent interactions with host cells
Tuberculosis (TB) is a multifaceted disease that has extensive variation in clinical manifestations despite being the product of infection with a single pathogen, Mycobacterium tu...
Human macrophage variation & TB pathogenesis
Variation in clinical outcomes after Mtb exposure ranges from resistance to infection to disseminated disease. Human genetic and cellular mechanisms of resistance and disseminatio...
Mtb strain-dependent mechanisms of pathogenesis in mouse models
Tuberculosis (TB) is a highly heterogeneous human disease that develops in some, but not all, individuals who inhale 1-3 infectious bacilli of Mycobacterium tuberculosis (Mtb). TB...
Administrative Core
PROJECT SUMMARY/ABSTRACT Administrative Core The administrative core will oversee the coordination of the Program as a whole. Specifically, it will be in charge of supervising t...
Research Bronchoscopy and Biospecimens Core
PROJECT SUMMARY/ABSTRACT Core B: Bronchoscopy and Biospecimens The goal of this core is four-fold. First, the core is responsible for performing bronchoscopy on study subjects t...
Primary Human Airway Cell Culture Core
PROJECT SUMMARY/ABSTRACT Core D Cell Culture The goal of the work described in this proposal is to collect grow, store and expand airway epithelial cells and smooth muscle cells...
Pulmonary Biostatistics Core
PROJECT SUMMARY/ABSTRACT Core E The Core will provide severe asthma investigators from each of the three Projects all facets of statistical support, including experimental desig...
S-nitrosylation signaling in asthma
PROJECT SUMMARY/ABSTRACT Project 1 Asthma afflicts over 7% of Americans and is the result of chronic inflammation of the airways leading to airway remodeling and hyperresponsive...
Airway pH regulation in asthma
PROJECT SUMMARY/ABSTRACT Project 2 The airway epithelium, like the renal tubular epithelium, expresses proteins that regulate luminal pH. For example, glutaminase regulates ammo...
Androgen signaling in asthma
PROJECT SUMMARY/ABSTRACT Asthma is a sexually dimorphic disease, with women exhibiting higher asthma prevalence and more severe manifestations than men. Projects 3 builds upon th...