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99,167 grants found
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Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid Hemorrhage
Abstract Subarachnoid hemorrhage (SAH) accounts for 5% of all strokes, has a high mortality and the cost to society is similar to ischemic stroke since subjects are much younger. T...
Safety and Cognitive Effects of Acute Intermittent Hypoxia-Induced Neuroplasticity in TBI
The purpose of this study is to determine whether Acute Intermittent Hypoxia (AIH) is safe to administer to medically stable chronic traumatic brain injury (TBI) patients. There is...
Testing a culturally targeted narrative video to reduce disparities in the use of genetic counseling and testing in Latina women at-risk of HBOC
ABSTRACT National guidelines recommend that women at increased risk for Hereditary Breast and Ovarian Cancer (HBOC) due to BRCA1/2 mutations be referred for genetic counseling and...
Community Paramedicine Program to Improve Diabetes Management among Adults Experiencing Severe Hypoglycemia
PROJECT SUMMARY/ABSTRACT Severe hypoglycemia in the management of diabetes is associated with high morbidity, mortality, psychological distress, and impaired quality of life (QoL)....
ROS Targeted Therapy for Lethal Prostate Cancer
PROJECT SUMMARY Prostate cancer (PC) is the second leading cause of cancer mortality in American men. Current therapeutics only show marginal efficacy and are often associated with...
Pericytes differentiate into smooth muscle cells through HIF2a/SDF1 activation
ABSTRACT Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by elevated lung pressures, right heart failure, and premature death. Current therapies...
A Randomized Controlled Trial: Genetic Counseling Patient Preference Intervention via Electronic Health Record Portal vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer
PROJECT SUMMARY Women at elevated risk for breast cancer should complete genetic counseling and may require more frequent screening or additional tests (e.g. breast magnetic resona...
Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells
Project Summary The goal of this project is to develop new technology to detect circulating tumor cells (CTCs) directly in the bloodstream without having to draw blood samples. Met...
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
Project Summary The anti-angiogenic agent bevacizumab (BEV) is one of the most effective forms of biologic therapy developed thus far for cervical cancer (CC). However, response is...
Leveraging Mechanical Control of Relaxation to Improve Diastolic Function
7. PROJECT SUMMARY/ABSTRACT Impaired diastolic relaxation, an important component of diastolic dysfunction, is present in nearly all patients with heart failure-both with reduced a...
SCH: Context-aware Freezing of Gait mitigation in real-world setting
See attached. RELEVANCE (See instructions): See attached.
Elucidating mechanisms for enhanced anaerobic bioremediation in the presence of carbonaceous materials using an integrated material science and molecular microbial ecology approach
PROJECT SUMMARY: Halogenated compounds, including legacy pollutants (e.g., chlorinated ethenes (CEs), polychlorinated biphenyls) and emerging contaminants (e.g., 1,2,3-trichloropro...
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level
Project Summary/Abstract Heart failure (HF) is a growing cause of morbidity and mortality. Despite the best available treatments, prognosis remains poor for many HF patients unders...
Cell cycle dependent mechanisms triggering lumen formation in vivo
SUMMARY STATEMENT: In humans and other vertebrates, motile cilia located in an organ of asymmetry play an important role in cardiac left-right development. Evidence from model orga...
Mitochondrial 2-hydroxyglutarate dehydrogenases modulate the cellular epitranscriptome
There is increasing recognition of mitochondria as signaling organelles. An important facet of this “adjunct” mitochondrial function is epigenetic modulation, as exemplified by the...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in eukar...
Methods for sequencing data analysis and archive-scale data science
PROJECT SUMMARY We will develop methods and maintain software that make it radically easier for biomedical researchers to use and understand sequencing data. The project will suppo...
Molecular Mechanisms of HFpEF-associated Atrial Fibrillation
PROJECT SUMMARY It is said that heart failure with preserved ejection fraction (HFpEF) is the single greatest unmet need in cardiovascular medicine. Patients with HFpEF are uniquel...
Leveraging Health System Telehealth and Informatics Infrastructure to Create a Continuum of Services for COVID-19 Screening, Testing, and Treatment: A Learning Health System Approach
PROJECT SUMMARY/ABSTRACT The COVID-19 pandemic reached the US with little warning, and thus caught both public health and medical care delivery systems inadequately prepared to cop...
NON-NUCLEASE BASED GENE EDITING FOR HUTCHINSON-GILFORD PROGERIA
Project Summary There is substantial interest in gene editing as a means to treat human genetic disorders such as Hutchinson- Gilford Progeria Syndrome (HGPS). Much effort has been...