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99,167 grants found
Showing 99,021 – 99,040 of 99,167 grants
Predicting Adolescent Depression Using Machine Learning
PROJECT SUMMARY Depression is an impairing and prevalent mood disorder in adolescence, affecting 1 in 6 youth by age 18. So far, the use of conventional statistical approaches has...
Repurposing Endonuclease V for the detection and engineering of adenosine-to-inosine editing
Project Summary/Abstract RNA editing is a widespread strategy employed by cells to post-transcriptionally alter protein sequence and gene expression levels. Adenosine-to-inosine (A...
Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.
Project summary Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral neuropathy resulting from demyelination and axon degeneration. Many cases of axon degeneration are caus...
Synaptic transmission at retinal ribbon synapses
In sensory cells of the eye and inner ear the neurotransmitter glutamate is released at active zones in a graded and continuous manner. These cells have evolved specialized structu...
Noninvasive measurement of oxygenation using quantitative susceptibility mapping
PROJECT SUMMARY/ABSTRACT The goal of this research is to develop cardiac quantitative susceptibility mapping (QSM) for non-invasive meas- urement of blood oxygen saturation, toward...
Regulating transcription of the key neural lineage driver ASCL1
The bHLH transcription factor ASCL1 (HASH1/MASH1) is essential for neuronal differentiation and sub-type specification of multiple neuronal cell-types throughout the brain, spinal...
Abscission regulation of corticogenesis
Abstract: In order for the brain to develop with proper size and structure, neural stem cells (NSCs) at early ages must make proliferative divisions and maintain their stemness to...
Central Nervous System Plasticity in Airway Disease
PROJECT SUMMARY Exacerbations (asthma attacks) account for nearly one-third of all asthma deaths. Despite psychiatric illness as a risk factor for death from asthma, and many conne...
Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism
Multiple hypotheses have been put forward regarding cortical circuit dysfunction in autism, including: excitation to inhibition (E/I) imbalance, hyper- or hypo- connectivity profil...
Epitranscriptomics of the aging lung
ABSTRACT Normal aging of the pulmonary system associates with a multitude of physiologic, anatomic and molecular changes in the lung. Epigenetic marks, non-sequence based variation...
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
This proposal brings together a unique interdisciplinary team with complementary expertise in high-LET radiobiology, pancreatic cancer research, and high-LET physics. It leverages...
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
Durable outcomes in subsets of solid cancer patients treated with immune checkpoint inhibitors (ICI) or adoptive cell transfer (ACT) immunotherapy has driven interest in gaining a...
Connecting AMD SNPs to Functions Using Allele-specific Interactions
PROJECT SUMMARY. Age-related Macular Degeneration (AMD) is a retinal neurodegenerative disease that is a major cause of vision loss among the elderly worldwide. Although anti-VEGF...
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively infl...
Targeting pathologic spike-ripples to isolate and disrupt epileptic dynamics
Project Summary Epilepsy is the world’s most common, serious brain disorder, affecting nearly 50 million people worldwide. For one-third of patients, seizures remain poorly control...
Dissecting Neural Circuits Involved in Musculoskeletal Pain
There is an unmet need to identify therapeutic approaches to alleviate pain associated with inflammatory and osteoarthritic (OA) joint conditions. Joint pain affects over 50 millio...
Managing Cardiac Toxicities of Cancer Therapy
Project Summary This R35 application proposes to capitalize on previous work produced by the PI over the past 11-years and to further serve as a strong foundation for interrogating...
Rapid Understanding of Best Practices in Rural Intensive Care (RUBRIC)
PROJECT SUMMARY/ABSTRACT Background: Nearly 15% of Americans live in rural communities, but only 1% of intensive care unit (ICU) beds are located in those same communities. The COV...
Lung IDO-1+ TNFR2+ cDC2 subset in control of lung mucosal tolerance: Mechanism and Application
Abstract The lung is a natural tolerogenic organ. Lung mucosal tolerance must be exquisitely controlled by the lung immune system to avoid the development of chronic inflammatory l...
Tissue Damage-Driven Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is responsible for ~10% of total cancer mortality worldwide. SCC prognosis is context-dependent and does not seem to be determined by driver gene soma...