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99,167 grants found
Showing 99,021 – 99,040 of 99,167 grants
M. tuberculosis strain-dependent interactions with host cells
Tuberculosis (TB) is a multifaceted disease that has extensive variation in clinical manifestations despite being the product of infection with a single pathogen, Mycobacterium tu...
Human macrophage variation & TB pathogenesis
Variation in clinical outcomes after Mtb exposure ranges from resistance to infection to disseminated disease. Human genetic and cellular mechanisms of resistance and disseminatio...
Mtb strain-dependent mechanisms of pathogenesis in mouse models
Tuberculosis (TB) is a highly heterogeneous human disease that develops in some, but not all, individuals who inhale 1-3 infectious bacilli of Mycobacterium tuberculosis (Mtb). TB...
Administrative Core
CORE SUMMARY / ABSTRACT The Administrative Core will manage the budgetary, administrative, and communication aspects of this Program. The Core will be responsible for coordinatin...
Core A: Elucidating the Mechanisms Underlying Mixed-Chimerism Based Tolerance
CORE SUMMARY / ABSTRACT Tolerance of kidney allografts has been achieved in monkeys and patients via transient mixed hematopoietic chimerism. However, until now, our current mixe...
Project 1: Augmenting Regulatory Mechanisms in Protocols of Transient Mixed Chimerism
PROJECT SUMMARY / ABSTRACT Induction of immune tolerance is the ultimate goal in the field of organ transplantation. Achieving a state of tolerance would lead to indefinite graft...
Project 2: Next-Generation Mixed Chimerism Induction for Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT Heart transplantation represents the best therapeutic option for patients with end-stage cardiac disease. However, while one-year success rates are rea...
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT The unifying goal of this Program is to design new and innovative strategies that achieve clinically-relevant heart allograft tolerance in 2-month-dela...
NAPS2 Administrative Core
ABSTRACT: NAPS2 ADMINISTRATIVE CORE Synucleinopathies including Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) in aggregate afflict ~...
NAPS2 Clinical Core
ABSTRACT: NAPS2 CLINICAL CORE The North American Prodromal Synculeinopathy Consortium for RBD, Stage 2 (NAPS2) protocol represents an expanded and integrated international resear...
NAPS2 Biofluid Core
ABSTRACT: NAPS2 BIOFLUID CORE REM sleep behavior disorder (RBD) is commonly a prodromal manifestation of diseases defined by pathologic alpha-synuclein (aSyn) protein accumulati...
NAPS2 Neuroimaging Core
ABSTRACT: NAPS2 NEUROIMAGING CORE The Neuroimaging Core of the North American Prodromal Synucleinopathy Consortium on RBD, Stage 2 (NAPS2) will ensure that state-of-the-art tech...
NAPS2 Polysomnogram Core
ABSTRACT: NAPS2 POLYSOMNOGRAM (PSG) CORE Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment behavior, and its neurophysiologic signature...
NAPS2 Data Management and Statistics Core
ABSTRACT: NAPS2 DATABASE MANAGEMENT AND STATISTICS (DMS) CORE The Data Management and Statistics (DMS) Core of the North American Prodromal Synucleinopathy Consortium on RBD, Sta...
NAPS2 Recruitment, Education, and Outreach Core
ABSTRACT: NAPS2 RECRUITMENT, EDUCATION AND OUTREACH (REO) CORE Rapid eye movement (REM) sleep behavior disorder (RBD) is unique parasomnia of clinical and basic physiological imp...
Project: Predicting Phenoconversion
ABSTRACT: NAPS2 PROJECT – PREDICTING PHENOCONVERSION Rapid eye movement (REM) sleep behavior disorder RBD is a condition in which the muscular paralysis that accompanies REM sle...
Administrative Core for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: ADMINISTRATIVE CORE The overarching goal of the Administrative Core is to provide the operational support necessary to successfully achieve the goals we have laid out f...
Scientific Human Biomarker Exposure Monitoring Core (HEMC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: HUMAN BIOMARKER EXPOSURE MONITORING CORE (HEMC) The Scientific Human Biomarker Exposure Monitoring Core (HEMC) is a state-of-the-art Core Laboratory at Stanford School...
Data Management and Analysis Core (DMAC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: DATA MANAGEMENT AND ANALYTICS CORE (DMAC) Data Management and Analytics Core (DMAC) and the overall goals that provide support to the Scientific Human Biomarker Exposur...
Project 1 for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) Study
ABSTRACT: PROJECT 1 Air pollution, particularly particulate matter <2.5µm (PM2.5) comprising a variety of organic molecules produced by combustion, is a significant driver of chr...