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99,167 grants found
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The role of the proximal nephron in salt-sensitive hypertension
The dramatic rise in U.S. fructose consumption mirrors the increase in the incidence of hypertension. More than 17 million Americans consume >20% of their calories as fructose a...
Molecular functions of human zinc transporter-8 in pancreatic beta cells
Abstract Zinc is a ubiquitous biological metal found in about 10% of the eukaryotic proteome. The spatiotemporal zinc dynamics provides crucial cellular signaling opportunities, bu...
Nonlinear performance analysis and prediction for robust low dose lung CT
1 PROJECT SUMMARY / ABSTRACT 2 Nonlinear algorithms such as model-based reconstruction (MBR) and deep learning (DL) reconstruction have 3 sparked tremendous research interest in re...
Aspirin to prevent cardiac dysfunction in preeclampsia
ABSTRACT Preeclampsia (PE) is a disease of late pregnancy characterized by hypertension and organ damage, which not only increases peripartum morbidity but is associated with the p...
Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial
Osteoporosis is a disease of aging that leads to ~2 million fractures and ~$17 billion in healthcare costs annually. Although several drugs are FDA-approved for the treatment of os...
The Influence of School Start Time on Sleep, Academic Achievement, and Behavioral Outcomes in Adolescents
PROJECT SUMMARY Although the National Sleep Foundation recommends 8.5 to 9.25 hours of sleep per night for adolescents, more than half of US 16-year-olds regularly get less than se...
SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSION
Inflammatory macrophages play a key role in the development and progression of the atherosclerosis, leading to myocardial infarction (MI). Sphingolipids are both membrane component...
Proteomic determinants of response to checkpoint blockade in malignant pleuralmesothelioma
PROJECT SUMMARY / ABSTRACT Malignant pleural mesothelioma (MPM) is a fatal cancer of the lining of the lungs that has defeated standard therapies for decades. Immune checkpoint inh...
Novel gastrocnemius muscle characteristics in peripheral artery disease patients associated with impaired functional performance
Lower extremity peripheral artery disease (PAD) significantly affects aging populations and results in functional impairment. Although the clinical importance of finding efficaciou...
A sequential, adaptive model of differentiated service delivery to reach persons living with HIV who are lost-to-follow-up or who have detectable viral load
ABSTRACT Globally, more than half of the world's 37 million people living with HIV are on antiretroviral therapy (ART) representing immense and encouraging success with access...
Quality, Safety, Value: Impact of sudden shift to telehealth due to COVID-19 within Nurse-led care models located in Colorado rural and urban communities
Quality, Safety, Value: Impact of Sudden shift to Telehealth due to COVID-19 within Nurse-led care Models located in Colorado Rural and Urban Communities Project Summary COVID-19 h...
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine
PROJECT SUMMARY: Inflammatory bowel disease (IBD) is an increasingly prevalent disease that currently affects ~1.3% of adults in the US. IBD is characterized by chronic inflammator...
Two-Dimensional Multi-Stage Isotachophoretic Technology for Multiplex Analysis of Cancer Exosomes and Proteins Marker Panel
Abstract Exosomes are small-sized (30–120 nm) extracellular vesicles. They are secreted by most cell types and play important roles in extracellular communication in normal and pat...
Developmental Regulation of Gene Expression by Long Undecoded Transcript Isoforms
PROJECT SUMMARY Dynamic gene expression programs drive essential biological processes including cellular differentiation and stress response pathways. During these processes, cells...
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infection
PROJECT SUMMARY: Zika virus (ZIKV) is a teratogenic human pathogen that causes congenital eye and brain diseases. Affected babies exhibit vision impairment and associated ocular pa...
The Impact of Aging on Prostate Cancer with Age-Related Disruption of Th17/Treg Axis
Project Summary/Abstract: Prostate cancer (PCa) is particularly important in elderly men because of the high incidence and prevalence of disease and mortality in this group of pati...
Telehealth to Improve Prevention of Suicide (TIPS) in EDs
ABSTRACT Significance: Our study will rigorously evaluate whether synchronous, within-visit telemental health evaluation and intervention services can successfully overcome poor ac...
Optimal Inspired Oxygen during Chest Compressions in Neonatal Resuscitation
ABSTRACT Birth asphyxia is a global issue accounting for about 23% of approximately 2.5 million neonatal deaths each year. These asphyxiated newly born infants require extensive re...
Molecular mechanistic studies of long “noncoding” RNAs in mammalian cell differentiation
PROJECT SUMMARY The goal of this study is to determine the molecular mechanisms by which long “noncoding” RNAs regulate mammalian cells differentiation. Long noncoding RNAs (lncRNA...
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotype
PROJECT SUMMARY Rapid evolutionary adaptation is a foundational process in biology and at the core of many issues facing humanity including cancer, bacterial and viral diseases, ev...