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99,167 grants found
Showing 98,961 – 98,980 of 99,167 grants
Administrative Core
CORE SUMMARY / ABSTRACT The Administrative Core will manage the budgetary, administrative, and communication aspects of this Program. The Core will be responsible for coordinating...
Core A: Elucidating the Mechanisms Underlying Mixed-Chimerism Based Tolerance
CORE SUMMARY / ABSTRACT Tolerance of kidney allografts has been achieved in monkeys and patients via transient mixed hematopoietic chimerism. However, until now, our current mixed...
Project 1: Augmenting Regulatory Mechanisms in Protocols of Transient Mixed Chimerism
PROJECT SUMMARY / ABSTRACT Induction of immune tolerance is the ultimate goal in the field of organ transplantation. Achieving a state of tolerance would lead to indefinite graft s...
Project 2: Next-Generation Mixed Chimerism Induction for Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT Heart transplantation represents the best therapeutic option for patients with end-stage cardiac disease. However, while one-year success rates are reaso...
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
PROJECT SUMMARY / ABSTRACT The unifying goal of this Program is to design new and innovative strategies that achieve clinically-relevant heart allograft tolerance in 2-month-delaye...
Administrative Core
Abstract The primary goal of the Administrative Core (Core C) is to support and promote the program and data management goals of this TBRU. Amongst its responsibilities, Core C wil...
Genetics & Clinical Cohorts
To achieve a 95% reduction of TB deaths by 2035 the WHO END-TB strategy states that critical introduction of new tools, such as a vaccine, drugs and treatment regimes, and a point-...
Systems Biology, Bioinformatics, & Data Integration
Genome-wide research strategies provide unprecedented opportunities for insight but also major bioinformatic challenges due to the size and complexity of the data. The multidiscipl...
M. tuberculosis strain-dependent interactions with host cells
Tuberculosis (TB) is a multifaceted disease that has extensive variation in clinical manifestations despite being the product of infection with a single pathogen, Mycobacterium tub...
Human macrophage variation & TB pathogenesis
Variation in clinical outcomes after Mtb exposure ranges from resistance to infection to disseminated disease. Human genetic and cellular mechanisms of resistance and dissemination...
Mtb strain-dependent mechanisms of pathogenesis in mouse models
Tuberculosis (TB) is a highly heterogeneous human disease that develops in some, but not all, individuals who inhale 1-3 infectious bacilli of Mycobacterium tuberculosis (Mtb). TB...
Administrative Core (Core A)
ABSTRACT ? CORE A The Administrative Core (Core A) will be the central hub of our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Outreach (ENA...
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
ABSTRACT ? PROJECT 1 Endometriosis is a chronic, estrogen-dependent, inflammatory disease that affects ~10% of reproductive age women, resulting in debilitating pelvic pain, infert...
Mass Spectrometry-based Global Molecular Approaches and Computational Tools to Determine Phenotypic and Environmental Signatures of Endometriosis
ABSTRACT ? PROJECT 2 Approximately 10% of reproductive-aged women are diagnosed with endometriosis, an inflammatory, estrogen- dependent disorder characterized by endometrial tissu...
Project 1: Elucidating the genetics and cell of origin of pancreatic cancer initiation
ABSTRACT (Project 1) Pancreatic ductal adenocarcinoma (PDAC) is a prevalent and almost uniformly fatal malignancy. Human PDAC genome sequencing has identified recurrent mutations...
Project 2: Immune signals promoting pancreas cancer stemness and progression
ABSTRACT (Project 2) There is an urgent need to discover improved therapies for pancreatic ductal adenocarcinoma (PDAC), which require a better understanding of mechanisms unde...
Project 3: Impact of tumor genetics on PDAC immunobiology and responses to macrophage-targeted immunotherapy
ABSTRACT (Project 3) Pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy that is poorly responsive to treatment, is characterized by a prominent infiltration of imm...
Administrative and Biostatistics Core
ABSTRACT (Core A-Administrative and Biostatistics Core) This application seeks support for its efforts to discover, apply, and translate scientific knowledge about pancreatic c...
Core B: Human Pancreas
ABSTRACT: Stanford Human Bio-bank for Pancreas Cancer Research (Core B) The Stanford Human Bio-Bank for Pancreas Cancer Research (Core B) will support human tissue and cell stud...
Core C: CODEX Core
ABSTRACT (Core C) A central focus of our program is understanding the roles of specific cell types, including immune cell populations, throughout the initiation, development and...