Browse All Grants
99,167 grants found
Showing 98,961 – 98,980 of 99,167 grants
Vascular calcification and atherosclerosis
Project Summary/Abstract Cardiovascular disease (CVD) is the leading cause of death in the U.S., with the annual total cost of care estimated at $351 billion. Vascular calcificatio...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computationa...
Highly Selective Catalytic Reactions of Alkenes and Alkynes Relevant to Medicinal and Process Chemistry
Project Summary/Abstract A recent critical analysis of biologically active molecules and reactions most often used for their preparation suggests that fraction of saturated carbons...
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
ABSTRACT Despite substantial experimental evidence for the important functional role of myeloid-biased HSC (myHSC) in stress, inflammation and aging, the mechanisms which control m...
Oxylipin Signaling in Congenital Heart Disease
Project summary Congenital heart defects (CHD) constitute the most common type of congenital defect in humans, however the causes for CHD in most cases are unknown. Lipoxygenase-de...
Characterization of Alternative Polyadenylation in Alzheimer's Disease
Abstract Alzheimer's disease (AD) is a slowly progressive brain disorder characterized by cognitive decline, irreversible memory loss, disorientation, and language impairment....
Investigation of the molecular mechanisms of vascular endothelial dysfunction in Hutchinson-Gilford Progeria Syndrome through in vitro 2D and 3D models
Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a rare, genetic disorder with features of accelerated aging. The majority of HGPS cases caused by a de novo point mutation i...
Probing cytosolic nucleic acid sensing pathways in cancer
ABSTRACT The ability of mammalian cells to elicit inflammation is central to many processes including embryogenesis, wound healing, tissue regeneration, and cancer metastasis. A ma...
Evaluating and Enhancing Health Information Technology for COVID-19 Response Workflow in a Specialized COVID-19 in a Medically Underserved Community
Project Summary/Abstract The COVID-19 pandemic has exposed vulnerabilities across the United States healthcare system and provided a serious test of hospitals’ resilience. The syst...
Analysis of conserved eukaryotic transcription elongation factors
PROJECT SUMMARY/ABSTRACT The long-term objectives of this project are to increase our understanding of eukaryotic transcription elongation, with a focus on histone chaperones. Hist...
Uptake and Patterns of Use of the IQOS Heated Tobacco System by US Smokers
Project Abstract On April 30, 2019, the U.S. Food and Drug Administration (FDA) issued a marketing order authorizing the IQOS “Tobacco Heating System” (IQOS), manufactured by Phill...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic ou...
Computational- and experimental- driven discovery of splicing regulation and circRNA function
Project Summary/Abstract Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcribe and process gene...
Sensorimotor learning through adjustments of cortical dynamics
Abstract Extensive research spanning theory, psychophysics, and physiology has investigated how we rely on statistical regularities in the environment to improve our sensorimotor b...
Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell disease
Project Summary Silent cerebral infarction is a serious consequence of sickle cell disease (SCD), affecting ~40% of patients by age 15. Although these injuries accumulate occultly,...
Bioprintable composite materials and microfluidic tools for vocal fold restoration and repair
PROJECT SUMMARY/ABSTRACT: Voice disorders are among the most common communication disorders across the lifespan. Approximately 3- 9% of the general population, including children a...
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
PROJECT SUMMARY Our continued inability to develop selective therapies that prevent the emergence of disseminated breast tumor cells into lethal metastases necessitates new approac...
DNA Topoisomerase Misfunctioning in Neurological Disease
DNA topoisomerase II (Top2) carries out changes in DNA structure needed for efficient transcription, replication, and DNA repair. This enzymes introduce transient double strand bre...
Bcl-2 as a target in cancer
Project Summary Bcl-2, an anti-cell death protein, is overexpressed in about 40% of all human cancers and contributes to the development and progression of cancer. Overexpression o...
The Pdx1-recruited Swi/Snf chromatin remodeling complex regulates endocrine cell expansion and differentiation in vivo
PROJECT SUMMARY/ABSTRACT Pancreatic β-cells within the islets of Langerhans are required for glucose-stimulated insulin secretion and glucose homeostasis. Dysfunctional β-cell acti...