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99,167 grants found
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Developmental origins and early detection of ADHD and dysregulatory psychopathology
PROJECT SUMMARY: The goal of this proposal is to identify early life predictors of symptoms of ADHD and associated behavioral andemotional problems. To do so children are followed...
Interplay Between Nuclear Organization and Function
PROJECT SUMMARY/ABSTRACT Goals: Peri-Centromeric Heterochromatin (PCH) is required for genome stability/DNA repair, chromosome pairing, nuclear architecture, and transposon and gen...
Identifying the sequences and factors that govern the fate of elongating RNAPII
PROJECT SUMMARY: Precise control of gene expression during development and in response to signals is essential for organismal growth and homeostasis. Accordingly, gene expression i...
SARM1 functional polymorphisms and their contribution to ALS risk
Motor axon loss is a cardinal symptom of amyotrophic lateral sclerosis (ALS). Axon loss can be driven by a genetically encoded program in which the axon survival factors NMNAT2 and...
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense agai...
Stromal senescence in lethal prostate cancer: a novel target for prognosis and therapy
Our overarching hypothesis is that senescent stromal fibroblasts, especially if they elicit an inflammatory response, promote progression to lethal disease in men with prostate can...
Defining the function and mechanism of regulatory ribosomal ubiquitylation
PROJECT SUMMARY Protein homeostasis (proteostasis) relies on the continual surveillance and removal of defective translation products resulting from the relatively high error rates...
Senescent Vascular Cells as Mediators of Cognitive Decline
PROJECT SUMMARY The goals of this proposal are to (1) obtain experimental skills and career training necessary to develop an independent research program investigating mechanisms o...
Traditional healer-initiated HIV counseling and testing in rural South Africa
Project Summary In South Africa, HIV testing has been undermined by HIV stigma, distrust in the allopathic health system, a preference for traditional medicine, and distance to the...
Inside-out construction of the biliary system
Project Summary The intrahepatic biliary tree functions to drain bile from hepatocytic canaliculi away from the liver. Congenital or acquired abnormalities in the formation and pat...
Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?
High IOP is a major causal risk factor for glaucoma and is the target of all current glaucoma therapies. This project investigates pathways that control intraocular pressure. Abnor...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated variants...
A First-in-Class FAP-activated Protoxin to disrupt the Tumor-Stroma Parasitic Cycle fueling lethal Prostate Cancer Progression
Though initially responsive to hormonal therapy, prostate cancer (PCa) invariably progresses to an incurable metastatic castration-resistant state (mCRPC). Additionally, the propor...
Understanding and leveraging molecular diversity within the phytochrome superfamily
Understanding and leveraging molecular diversity within the phytochrome superfamily. Our proposal focuses on the phytochrome superfamily of photoreceptors. We have a longstanding i...
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
Project Summary: There is a rapidly growing body of evidence that Müller glia can are a source of retinal progenitors to promote neural regeneration. Many studies have demonstrated...
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract. Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as dec...
Second Generation Gene Therapy for APOE4 Homozygous Individuals at High Risk for Alzheimer's Disease
Alzheimer’s disease (AD), a degenerative brain disease and the most common cause of dementia, currently affects 5.8 million Americans and 50 million people worldwide.AD symptoms in...
Using nicotine to reverse age-related auditory processing deficits
Age-related decline in central auditory function significantly affects quality of life in the elderly, with impaired speech perception leading to increased risk for depression, soc...
Investigating Mechanisms of Hyperprogression on Anti-PD-1 Immunotherapy
Abstract The number of cancer patients being treated with checkpoint blockade immunotherapy (CBI) targeting the PD- 1/PD-L1 pathway is increasing dramatically. Recently a novel and...
Mechanisms of retinal degeneration in neuroinflammatory demyelinating diseases
An important question in the field of multiple sclerosis (MS) is whether myelin/axonal damage in the white matter facilitates neuronal cell body loss in the gray matter, or results...