Browse All Grants
99,167 grants found
Showing 98,921 – 98,940 of 99,167 grants
Administrative Core
PROJECT DESCRIPTION/ABSTRACT – ADMINISTRATIVE CORE The goal for our Center of Innovation for Brain Tumor Therapeutics is to develop effective novel therapeutic strategies for gl...
Therapy Evaluation Core
PROJECT DESCRIPTION/ABSTRACT – THERAPY EVALUATION CORE The goal of our Center of Innovation for Brain Tumor Therapeutics is to nominate only the most promising novel treatment s...
Pharmacology Core
PROJECT DESCRIPTION/ABSTRACT – PHARMACOLOGY CORE The Pharmacology Core will work closely with the project teams and the Therapy Evaluation Core to provide comprehensive pharmaco...
Novel DNA damage response inhibitor and alkylator combinations for GBM
PROJECT DESCRIPTION/ABSTRACT – PROJECT 1 Alkylating chemotherapies are part of the backbone of standard-of-care therapy in newly diagnosed disease, and they are also used in the...
WOOP VA: Mental Contrasting With Implementation Intentions to Promote Weight Management in Primary Care
Background: Approximately 40% of Veterans have obesity. Intensive weight management programs such as MOVE! promote clinically significant weight loss, but only 3-7% of eligible V...
Core A- Administrative Core
Abstract Core A will provide the administrative support for the Program Project and thus serves all three Projects and the other two Cores. Specifically, the core will provide th...
CORE B- Animal Models and Tissue Analysis
Project Summary The primary goal of this Program Project is to understand the molecular mechanisms by which the physiological and pathophysiological functions of integrins are re...
CORE C- Protein Expression and Purification
Project Summary/Abstract The proposed Animal Models and Tissue Analysis Core (Core C) is an essential component to the goals of this PPG. To support the research strategies and...
Project 1- Role of Kindlins in Blood and Vascular Cell Biology
Project Summary Kindlin-2 (K2) is the most broadly distributed of the three mammalian kindlins. It is present in fibrobasts, chondrocytes, and cardiomocytes, and its global knock...
Project 2- Mechanistic Role of Talin in Cellular Signaling
Project Summary The long-term objective of this proposal is to understand the activation and signaling mechanisms of integrins – a class of heterodimeric transmembrane receptors...
Project 3- Role of Leukocyte-Platelet Interactions in Inflammation and Thrombosis
PROJECT SUMMARY/ABSTRACT This translational project will focus on systemic lupus erythematosus (SLE) as a unique disease model of inflammation and thrombosis. SLE is a complex a...
MDM2 inhibitor therapy for TP53 wild-type GBM
Project Summary – Project 2 Disruption of tumor suppressor p53 function is the most common alteration in cancer and results in dysregulation of DNA repair following genotoxic in...
Network Coordinating Center
PROJECT SUMMARY/ABSTRACT – NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of...
Clinical and Biostatistics Core
Project Summary/Abstract – Clinical and Biostatistics Core The Clinical and Biostatistics Core (CBC) is a central component of the Evaluating Modes of Influenza Transmission (EMI...
Advanced Bioaerosols Technology Core
Project Summary/Abstract – Advanced Bioaerosol Technology Core The Advanced Bioaerosol Technology Core (ABTC) will develop a comprehensive suite of innovative technologies for im...
Evaluating Modes of Influenza Transmission using a Randomized Controlled Trial (EMIT-2-RCT)
Project Summary/Abstract – Evaluating Modes of Influenza Transmission using a Randomized Controlled Trial The “Evaluating Modes of Influenza Transmission using a Randomized Contr...
Developing and Applying Analytical Models of Influenza Transmission
Our current scientific knowledge indicates the importance of influenza transmission via exhaled viral bioaerosols over short and long ranges in indoor environments. The turbulent...
Targeted Contact Precaution Use to Prevent MRSA Transmission
Background: There remains tremendous controversy surrounding the pros and cons of contact precautions for methicillin-resistant Staphylococcus aureus (MRSA). The rationale for thi...
Administrative Core
ADMINISTRATIVE CORE: ABSTRACT Natives Engaged in Alzheimer?s Research (NEAR) will be organized into an Administrative Core, a Recruitment and Engagement Core, a Biospecimen Core, a...
Research Methods Core
RESEARCH METHODS CORE: ABSTRACT Healthy People 2020 calls for research and policy to eliminate racial and ethnic disparities in health status, health behaviors, functional limitati...