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99,167 grants found
Showing 98,881 – 98,900 of 99,167 grants
IMPACT Project 3 – Engaging clinical champions to improve HPV vaccine communication and uptake in healthcare systems
ABSTRACT ? Project 3 Widespread HPV vaccination could prevent most HPV cancers, but uptake among US adolescents remains far below national goals. To increase uptake, we developed...
IMPACT Project 4 – Budget impact, cost-effectiveness, and population outcomes of interventions to improve HPV vaccine communication and uptake in rural and nonrural communities
ABSTRACT ? Project 4 Human papillomavirus (HPV) cancers are preventable through vaccination. Yet HPV vaccine coverage is well below the national goal of 80%, especially in rural a...
Administrative Core – Improving Provider Announcement Communication Training (IMPACT)
ABSTRACT ? Administrative Core The Administrative Core will provide overall guidance, administrative support, and fiscal management for the P01 Program Project, ?Improving Provide...
Intervention Core - Improving Provider Announcement Communication Training (IMPACT)
ABSTRACT ? Intervention Core The Intervention Core will support the proposed Program Project, ?Improving Provider Announcement Communication Training (IMPACT)? with the goal of im...
Data Core – Improving Provider Announcement Communication Training (IMPACT)
ABSTRACT ? Data Core The Data Core will centralize data-related services across research projects for the P01 Program Project, ?Improving Provider Announcement Communication Train...
Administrative Core
TBRU Administrative Core (Admin Core) The proposed TBRU application will be supported by an Administrative Core structure to assist, coordinate and maintain the TB Research Unit,...
Clinical Core
The TBRU Clinical Core will take overall responsibility for all human subjects? studies in the proposed TBRU protocols, and will work closely with the Data and Operations Managemen...
Systems Biology Core
SYSTEMS BIOLOGY CORE ABSTRACT This overall TBRU Program seeks to understand how both host and bacterial heterogeneity act together to promote TB clinical phenotypes such as transm...
Bacterial and host determinants of progression, manifestations and consequences of TB
ABSTRACT - PROJECT 1 Historically, TB has been characterized as a two-stage process ? infection and disease. It now is clear that infection and importantly the likelihood once infe...
Immune Determinants of the Course of Mycobacterium tuberculosis infection and Disease
ABSTRACT - PROJECT 2 Between the initial encounter of Mycobacterium tuberculosis (Mtb) with alveolar macrophages (AM) and the development of active disease lies a continuum in whic...
Minimizing in vivo Drug Tolerance induction in tuberculosis.
Abstract Project 3: Minimizing in vivo drug tolerance induction in tuberculosis. Phenotypic drug tolerance in Mycobacterium tuberculosis is an expression of one of the single most...
Drug tolerance, bacterial heterogeneity and adverse TB treatment outcomes
ABSTRACT - PROJECT 4 Perhaps the greatest barrier to improving tuberculosis (TB) treatment outcomes is the six months of multi- drug therapy that is required to reliably cure a pa...
Administrative Core
Not applicable to the Administrative Core.
Synthetic Biology and Optogenetics Core
Abstract The Program Project will employ in all projects novel engineered reagents that enable manipulation and interrogation of individual signaling pathways with precise spatia...
Advanced Imaging Core
Abstract Advanced Imaging Core C is essential to accurately define spatial and temporal organization of processes governing macrophage plasticity. Surface markers determined by f...
Patient Sampling and Genomics Core
PROJECT SUMMARY / ABSTRACT A critical translational component of this Program Project involves the correlative analysis of macrophages (Mφ) isolated from critically ill patients...
Ion Flux Regulation of Macrophage Plasticity in Lung Injury and Repair
PROJECT SUMMARY/ABSTRACT Macrophages (Mφ) are essential for the innate immune function of lungs. The ability of macrophages to integrate signals from microbes and the tissue nich...
CREB Programming of Alveolar Macrophage Population and Inflammatory Lung Injury
PROJECT SUMMARY/ABSTRACT The lung’s ability to recover from severe inflammatory injury depends on its capacity to rapidly mobilize intrinsic tissue repair pathways. Macrophages (...
Endothelial Instruction of Macrophage Fate in Inflammatory Lung Injury
PROJECT SUMMARY/ABSTRACT Studies have shown much broader roles for macrophages in responding to inflammation and tissue injury than previously recognized, such as promoting infla...
Cross-Protective Humoral Immunity to Coronavirus
PROJECT 1 SUMMARY Global establishment of Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is a continued human threat. While successful vaccine programs are well und...