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99,167 grants found
Showing 98,861 – 98,880 of 99,167 grants
Disparities in the Use of Oral Anticancer Agents in Kidney Cancer
We have long known that real-world black-white racial disparities have existed in the treatment and outcomes of patients with renal cell carcinoma (RCC).However, it is unclear how...
The Effects of Early Psychosocial Deprivation on Cardiometabolic Risk in Early Adulthood
Project Summary/Abstract The Bucharest Early Intervention Project (BEIP)?the only randomized controlled trial (RCT) comparing foster care to institutional care for young children?w...
Glycosylation Analysis by Sheath-Flow SERS
Project Abstract Protein glycosylation plays important roles in various human diseases, including cancer, inflammatory, and neurodegenerative diseases. Glycoproteins, therefore, ar...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability. In response to DNA damage, the cell activates several evolut...
Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
Abstract In the United States, colon cancer and rectal cancer are the third most common cancer diagnosed in both men and women. The standard of care for stage II-III rectal cancer...
The Role of Inflammation in Post-stroke Epileptogenesis
PROJECT SUMMARY/ABSTRACT OF PARENT GRANT Epilepsy is a common consequence of brain insults, such as brain injuries, status epilepticus, and cerebrocortical stroke in the elderly an...
Mechanisms modulating cell identity in regenerative mammalian epithelia
PROJECT SUMMARY: Significance: Our tissues experience frequent damage from injuries, infections and disease. Many organs in the human body can undergo self-repair to restore their...
Regulation of Skeletal Growth by Soft Tissue Extracellular Matrix
PROJECT SUMMARY Mutations in several secreted ECM proteins, including ADAMTSL2, ADAMTS10, ADAMTS17, LTBP2, LTBP3, and fibrillin-1 (FBN1), can cause acromelic dysplasias, such as ge...
Developing computational algorithms for histopathological image analysis
Project Summary Histopathology is the cornerstone of disease diagnosis and prognosis. With the advance of imaging technology, whole-slide image (WSI) scanning of tissue slides is b...
Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.
Parkinson’s Disease (PD) is a common neurodegenerative disorder affecting human movements. PD is not just a motor disease. It also results in impaired multi-sensory processing that...
Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant
The 2013?2016 Ebola virus (EBOV) disease epidemic was orders of magnitude larger than any previous EBOV outbreak.Preliminary data indicate that GP-A82V, an EBOV glycoprotein mutant...
Targeted activation of autoimmune checkpoints in B cell malignancies
Targeted therapy of cancer typically focuses on agents that suppress oncogenic signaling below a minimum threshold needed for survival and proliferation.Here, we propose a novel st...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for molecu...
Kidney PCSK9 in nephrotic syndrome
Summary / Abstract (max 30 lines): Nephrotic syndrome is a major manifestation of human glomerular disease, and patients with this condition develop large amounts of protein in the...
Cortical circuit mechanisms of visual shape processing
PROJECT SUMMARY Humans and other primates rely on using visual shape information to identify and interact with objects in the world. The goal of this project is to gain mechanistic...
Identifying primary targets of bumped kinase inhibitor derived compounds to improve utility as therapy for castration resistant prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer (CRPC) that inevitably escapes primary therapies most often retains dependency on androgen receptor (AR). We are repos...
Supraspinal Control of Human Locomotor Adaptation
Title Supraspinal Control of Human Locomotor Adaptation Abstract Advances in electroencephalography (EEG) technology have made it feasible to study electrical brain dynamics during...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability.In response to DNA damage, the cell activates several evoluti...
The Role of the Metaplastic Microenvironment in Barrett's Esophagus
Project Summary Esophageal Cancer is a leading cause of cancer death worldwide. The two subtypes include Esophageal Squamous Cell Carcinoma (ESCC) and Esophageal Adenocarcinoma (EA...
Exploring cyclic di-nucleotide signaling across the tree of life
Project Summary is not required for this equipment supplement.