Browse All Grants
99,167 grants found
Showing 98,841 – 98,860 of 99,167 grants
Project 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapy
PROJECT SUMMARY – PROJECT 4 Primary liver cancer, mainly hepatocellular carcinoma (HCC), is now one of the most deadly malignant diseases. Aging is a high-risk factor for HCC dev...
Administrative Core
PROJECT SUMMARY_CORE A Recovery from viral pneumonia is a clinically important yet understudied process. Severe viral pneumonia due to influenza A virus (IAV) or severe acute res...
Clinical Phenotyping and Human Core
PROJECT SUMMARY CORE B Lower respiratory tract infections cause nearly 80% of deaths from infectious diseases in the US, and respiratory viruses, such as influenza and SARS-CoV-2...
The Cell Phenotyping and Mouse Core
Project Summary The Cell Phenotyping and Mouse Core, designated as Core C, is a centralized facility that will provide investigators with a well-established and reproducible mode...
Project 1: Vimentin regulates host response and repair mechanisms to influenza A viral pneumonia
PROJECT SUMMARY PROJECT 1 Severe viral pneumonia, due to influenza A virus (IAV) damages the lower respiratory tract to cause acute respiratory distress syndrome (ARDS). The pers...
Project 2: Metabolic regulation of host response and repair mechanisms to influenza A viral pneumonia
Project summary Viral pneumonia is currently among the most common causes of death in the world. Viral pneumonia impairs tissue repair leading to both in-hospital death and prolo...
Project 3: Targeting linear ubiquitination to attenuate inflammation and promote repair after viral pneumonia
In this PPG, all of the Projects and Cores consider the persistence of respiratory failure and the development of multiple organ dysfunction in patients with ARDS as a failure of...
Administrative Core
PROJECT DESCRIPTION/ABSTRACT ? ADMINISTRATIVE CORE The goal for our Center of Innovation for Brain Tumor Therapeutics is to develop effective novel therapeutic strategies for glio...
Therapy Evaluation Core
PROJECT DESCRIPTION/ABSTRACT ? THERAPY EVALUATION CORE The goal of our Center of Innovation for Brain Tumor Therapeutics is to nominate only the most promising novel treatment str...
Pharmacology Core
PROJECT DESCRIPTION/ABSTRACT ? PHARMACOLOGY CORE The Pharmacology Core will work closely with the project teams and the Therapy Evaluation Core to provide comprehensive pharmacolo...
Novel DNA damage response inhibitor and alkylator combinations for GBM
PROJECT DESCRIPTION/ABSTRACT ? PROJECT 1 Alkylating chemotherapies are part of the backbone of standard-of-care therapy in newly diagnosed disease, and they are also used in the re...
MDM2 inhibitor therapy for TP53 wild-type GBM
Project Summary ? Project 2 Disruption of tumor suppressor p53 function is the most common alteration in cancer and results in dysregulation of DNA repair following genotoxic insu...
Network Coordinating Center
PROJECT SUMMARY/ABSTRACT ? NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of s...
Center Administrative Core
Administrative Core ABSTRACT The Administrative Core supports the goals of the Collaborative Center to Develop Improved Diagnostic and Therapeutic Approaches to Endometriosis of de...
Diagnosis and Treatment of Endometriosis: A Translational Approach
Project 1 (Young) Diagnosis and Treatment of Endometriosis: A Translational Approach ABSTRACT The Collaborative Center to Develop Improved Diagnostic and Therapeutic Approaches to...
SIRT1 as a Therapeutic Target in Endometriosis
Project 2: SIRT1 as a Therapeutic Target in Endometriosis ABSTRACT Progesterone resistance is now recognized as a key element in the pathophysiology of endometriosis, though its un...
Imaging and treatment of endometriosis in nonhuman primates
Project 3: Imaging and treatment of endometriosis in nonhuman primates SUMMARY/ABSTRACT The overarching goal of this P01 Center is to advance our understanding of the pathophysiolo...
Endometriosis Education Outreach
Endometriosis Education Outreach ABSTRACT Dysmenorrhea, painful periods, is the most common cause of absenteeism in young women. Endometriosis is the leading etiology; however, the...
Comparative Genomics and Bioinformatics Core
Comparative Genomics And Bioinformatics Core SUMMARY/ABSTRACT The Comparative Genomics and Bioinformatics (CGB) Core will provide state-of-the-art comparative genomic and bioinform...
Targeted Contact Precaution Use to Prevent MRSA Transmission
Background: There remains tremendous controversy surrounding the pros and cons of contact precautions for methicillin-resistant Staphylococcus aureus (MRSA). The rationale for this...