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99,167 grants found
Showing 98,841 – 98,860 of 99,167 grants
Senescent Vascular Cells as Mediators of Cognitive Decline
PROJECT SUMMARY The goals of this proposal are to (1) obtain experimental skills and career training necessary to develop an independent research program investigating mechanisms o...
How alpha-Synuclein misfolding promotes tau pathology in ADRD
Abstract The parent award to this Administrative Supplement for AD and ADRD research studies alpha-Synuclein (aSyn) oligomerization in great biophysical detail, using state-of-the-...
Multiscale Models of Wound Cell Plasticity for Regeneration
In regenerative medicine, it is critically important to understand the complex mechanisms that rewrite and stably maintain cellular memory in order to reprogram cells to the new, d...
Novel actions of neurosteroids on GABA (A) receptor trafficking
Project Summary This application is for a diversity supplement to the R01 NS108378, entitled ?Novel actions of neurosteroids on GABAAR trafficking? the PIs of which are Dr. Paul Da...
Methods to Identify, Validate & Interpret GWAS Loci in Multi-ethnic Meta-analysis
ABSTRACT Large scale genetic datasets have revolutionized human genetic research.In the past decade, genome-wide association studies have identified numerous genetic variants assoc...
The pursuit of genetic causal mechanisms
Project Summary Recent years have witnessed the development of large research projects that involve genotyping hundreds of thousands of individuals, on which we have available deta...
Mechanisms of hippocampal network-targeted stimulation to rescue memory impairment due to Alzheimer's disease
Supplement Project Summary/Abstract The purpose of this administrative supplement for our ongoing grant ?Cellular mechanisms of hippocampal network neuroplasticity generated by bra...
20-HETE Formation Inhibitors in Cardiac Arrest
Project Summary Evidence has demonstrated that 20-hydroxyeicosatetraenoic acid (20-HETE) is a key microvascular constrictive regulator and is formed by the omega-oxidation of arach...
Defining the Role of Microglia in the Synaptic Rewiring of the Hypothalamus by Early life Adversity
PROJECT SUMMARY: Early-life adversity can profoundly impact an individual?s risk for stress-related emotional disorders including depression, likely by modulating the maturation of...
Dissecting and reconstructing the molecular roadmaps of cellular reprogramming to iPSCs in single-cell resolution
Project Summary Understanding the molecular programs that guide cell fate conversion will provide a foundation for the development of tools to convert cell fate and eventually faci...
Brain Single-nuclei and iPS-derived cells transcriptomic analysis to define the contribution of neuronal and glial pathw
Abstract Alzheimer?s disease (AD) is a complex and heterogenous condition in which multiple molecular pathways are disrupted in different cell-types and lead to disease.Genetic fin...
Inhibition of Candida Virulence and Biofilm Formation by a Bacterial Peptide
PROJECT SUMMARY The medical condition oropharyngeal candidiasis (OPC) is a major source of oral morbidity in patient groups including the immunosuppressed (cancer and AIDS patients...
In vivo Drug Testing of Pediatric CNS Tumors Using Patient Derived Orthotopic Xenograft Models
PROJECT SUMMARY/ABSTRACT This application is prepared for an extension of our previously funded research proposal that was in response to RFA-CA-14-018, Pediatric Preclinical Testi...
Neurocognitive Consequences of Intermittent Hypoxia
Abstract Sleep apnea is a respiratory disorder that causes intermittent hypoxia (IH) and is known to negatively impact learning and memory. Neurobiological processes within the hip...
How does disrupting parvalbumin interneuron-generated gamma oscillations affect the encoding of rule shifts in the prefrontal cortex?
PROJECT SUMMARY (PARENT GRANT) Rhythmic fluctuations of electrical activity in the brain are frequently observed during cognitive tasks. In many cases these oscillations are synchr...
Cellular and molecular control of tooth morphogenesis
ABSTRACT Tooth bioengineering is of great interest, because dental decay and tooth loss constitute an important public health issue.Additionally, tooth anomalies are common in many...
Large-scale recording of spike train ensembles from muscle fibers during skilled behavior in mice and songbirds
A crucial problem in neuroscience is to understand how the brain coordinates muscle activity to produce behavior.For decades, researchers have approached this problem by recording...
Diversity Supplement to 2R01NS064004
Hyperreflexia is a devastating consequence of a lesion that damages the corticospinal tract (CST), in isolation, or at its origins in the cortex, or after a spinal cord injury (SCI...
Precision Medicine Approach: Using genomic information to guide TBI treatment
ABSTRACT Concussive injury or mild/moderate TBI (mTBI) accounts for a large majority of the brain injuries in USA and compromises neuronal function and cognitive abilities.The main...
Effects of TrkB Activation on Abnormalities in Neocortical FS interneuron
Project Summary Abnormalities in parvalbumin (PV) and somatostatin (SOM) interneurons are reported in a number of neurological disorders, including epilepsy. Therapy that improves...