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99,167 grants found
Showing 98,821 – 98,840 of 99,167 grants
Project 1: Panbetacoronavirus vaccines
Abstract - Project 1 Zoonotic coronaviruses (CoV) are responsible for three major epidemics/pandemics in the 21st century, including Severe Acute Respiratory Coronavirus (SARS-Co...
Project 2: PanbetaCoV protein vaccine design
Abstract – Project 2 Animal betacoronaviruses (betaCoVs), such as those that gave rise to SARS-CoV-1, MERS, and now SARS- CoV-2, represent a significant, continuous threat to hum...
Project 3: Nucleoside-modified mRNA-LNP vaccine platform
ABSTRACT - Project 3 Coronaviruses havethe potential to cause significant morbidity andmortality as demonstrated by the ongoing SARS-CoV-2 pandemic. The purpose of this program...
Project 4: Computational panbetaCoV immunogen design
Abstract - Project 4 SARS-CoV-2, a member of the genus Betacoronavirus (betaCoV), is the third major zoonotic outbreak of a highly pathogenic betaCoV in the last two decades. We...
Administrative Core
ADMININSTRATIVE CORE A SUMMARY To support this program, the Administrative Core A aims to administratively support the scientific activities of this group by enabling the free ex...
Administrative Core
PROJECT SUMMARY_CORE A Recovery from viral pneumonia is a clinically important yet understudied process. Severe viral pneumonia due to influenza A virus (IAV) or severe acute respi...
Core B: Mouse Models of Aging and Cancer
PROJECT SUMMARY ? CORE B Understanding aging in the liver and the role of aging in liver cancer development will require investigation in live animals as well as genetic and non-ge...
Core C: Integrated Cancer and Aging Bioinformatics
PROJECT SUMMARY ? CORE C Understanding aging in the liver and the role of aging in liver cancer development will require the collection, QC, analysis, and integration of a large co...
Project 1: The role of mitochondrial stress in liver aging and cancer progression and intervention via oxidative mitohormesis
PROJECT SUMMARY ? PROJECT 1 Mitochondrial dysfunction, oxidative stress and inflammation are hallmarks of aging and cancer, but crosstalk between these processes are not well under...
Project 2: Cytoplasmic chromatin fragments (CCF) as a driver of liver cancer and target for intervention during aging
PROJECT SUMMARY ? PROJECT 2 The incidences of liver cancer (primarily hepatocellular carcinoma (HCC)) are increasing and disease outcome is poor. Consequently, there is an urgent n...
Project 3: Chronic interferon and bile acid signaling as drivers of immunosuppression in age-related liver cancer
PROJECT SUMMARY ? PROJECT 3 Liver cancer is a leading cause of cancer related deaths world-wide (1,2). Age is a crucial risk for acquiring cancer as people older than 60 are more l...
Project 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapy
PROJECT SUMMARY ? PROJECT 4 Primary liver cancer, mainly hepatocellular carcinoma (HCC), is now one of the most deadly malignant diseases. Aging is a high-risk factor for HCC devel...
Data Science Core
SUMMARY / ABSTRACT ? Data Science Core With the introduction of the Big Data paradigm, scientific investigation has become increasingly dependent on the ability to collect, manage,...
Husbandry and Transgenics Core
SUMMARY / ABSTRACT ? Husbandry and Transgenics Core The core will support the needs of the U19 by developing new methods for large scale culture of Berghia and Aiptasia animals, an...
Multi-feature, Multi-scale Atlas
SUMMARY / ABSTRACT ? Project 1. Multi-feature, Multi-scale Atlas Project 1 of the Berghia Brain Project is to create a multi-scale, multi-feature atlas of the Berghia brain and per...
Behavioral Analysis and Recording
PROJECT 2 SUMMARY/ABSTRACT ? Project 2. Behavioral Analysis and Recording This project examines the behavior of nudibranch mollusc Berghia as part of the larger Berghia Brain Proje...
Large-scale Optical Recording
PROJECT SUMMARY ? Project 3. Large-scale Optical Recording Humans have both centralized and highly distributed nervous systems (e.g., brain and myenteric plexus) that are increasin...
Neurodevelopment
PROJECT SUMMARY / ABSTRACT ? Project 4. Neurodevelopment The goal of this Project is to provide a developmental perspective to the overall goals of the Berghia Brain Project to und...
Modeling and Theory
SUMMARY/ABSTRACT ? Project 5. Modeling and Theory This collaborative project will develop integrative, multi-scale models that incorporate data from all Projects in the Berghia Bra...
Project 3: Chronic interferon and bile acid signaling as drivers of immunosuppression in age-related liver cancer
PROJECT SUMMARY – PROJECT 3 Liver cancer is a leading cause of cancer related deaths world-wide (1,2). Age is a crucial risk for acquiring cancer as people older than 60 are more...