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99,167 grants found
Showing 98,781 – 98,800 of 99,167 grants
Activity-Dependent Tagging of Cerebellar Neurons for Studying Signal Processing and Learning
PROJECT SUMMARY The goal of the proposed research is to implement state-of-the-art techniques for recording and manipulating neurons based on their activity in the cerebellum, to d...
Lung Innate COVID-19 Defense Specific to Veterans Risk Characteristics
COVID-19 is now a global pandemic requiring a rapid and concerted response from the scientific and medical community.Based upon recent epidemiology derived only months earlier from...
A deubiquitination module controls Treg adaptation to tumor microenvironment
Project Summary: One of the recent advances in cancer treatment is the development of immunotherapy largely through targeting the checkpoint receptors. However, attempts at immunot...
Targeting the gut-brain axis to facilitate weight loss in high fat diet consumers
Current therapies for obesity treatment are effective at producing weight loss but weight loss maintenance remains a significant challenge (Franz et al., 2007; Sawamoto et al., 201...
COVID-19: Understanding The Role of Corona Virus InducedDisruption Of Alveolar Type 2 Cell Function And SurfactantHomeostasis In The Pathogenesis Of COVID-19 AcuteRespiratory Distress Syndrome
ABSTRACT The Severe Acute Respiratory Syndrome (SARS)-associated coronavirus 2 (SCoV2) is the cause of COVID-19 syndrome which is marked by a refractory acute lung injury that resu...
SCH: Context-aware Freezing of Gait mitigation in real-world setting
See attached. RELEVANCE (See instructions): See attached.
Synaptic transmission at retinal ribbon synapses
In sensory cells of the eye and inner ear the neurotransmitter glutamate is released at active zones in a graded and continuous manner. These cells have evolved specialized structu...
Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.
Project summary Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral neuropathy resulting from demyelination and axon degeneration.Many cases of axon degeneration are cause...
Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespan
This proposal examines how a novel TLR glial signaling pathway drives phagocytic competence in glia, and defines its function in pruning neuronal number and connectivity across lif...
Enhancing bioremediation of groundwater co-contaminated by chlorinated volatile organic compounds and 1,4-dioxane using novel macrocyclic materials
Project Summary The project addresses a common challenge in the remediation of groundwater contaminated with chlorinated volatile organic compounds (CVOCs) and 1,4-dioxane.CVOCs in...
Strategies to target BCR-ABL1 compound mutants in CML and Ph+ ALL
Abstract: Philadelphia chromosome-positive (Ph+) leukemia is caused by BCR-ABL1, a constitutively active fusion kinase.Tyrosine kinase inhibitors (TKIs) targeting the ATP site of B...
Mechanisms of Advanced NAFLD Disparities in Hispanics: A Multi-level Analysis
PROJECT SUMMARY/ABSTRACT Nonalcoholic fatty liver disease (NAFLD) leading to nonalcoholic steatohepatitis (NASH) is a major cause of chronic liver disease that may progress to cirr...
Cellular and molecular mechanisms underlying DDX3X syndrome
Abstract Mutations in DDX3X are strongly associated with autism spectrum disorder (ASD), and may account for 1-3% of unexplained developmental delay (DD) in females, making this on...
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heart
ABSTRACT - In the post-ischemic heart, relatively little is known about the injured-but-not-infarcted myocardium, which we call the intermediate zone as it is neither normal nor in...
The role and mechanistic regulation of cPLA2alpha in eicosanoid biosynthesis and wound healing
In recent years, new technological advancements in small molecule analyses (e.g., lipidomics) have identified a biochemical manifestation of impaired wound healing: the development...
Model-aided Design and Integration of Functionalized Hybrid Nanomaterials for Enhanced Bioremediation of Per-and Polyfluoroalkyl Substances (PFASs)
PROJECT SUMMARY Environmental contamination by per- and polyfluoroalkyl substances (PFASs) is a major public health concern because of the wide range of toxic effects that have bee...
COVID-19: Elucidating the Role of the NasalEpithelium in SARS-CoV-2 Infection, Transmission, and Prevention
ABSTRACT Severe acute respiratory syndrome coronavirus SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19) has led to a pandemic with a mortality of approximatel...
Modeling myelodysplasia
PROJECT SUMMARY Myelodysplastic Syndromes (MDS) are a cancer of the hematopoietic stem cell (HSC) on the rise in the aging population and cancer survivors.The only curative treatme...
Base editing and prime editing for sickle cell disease
PROJECT SUMMARY Despite advances in the medical care of sickle cell disease (SCD), most patients continue to experience severe pain, poor quality of life, progressive organ deterio...
Efficient Bioremediation of Environmentally Persistent Contaminants with Nanomaterial-Fungus Framework (NFF)
Project Summary The recalcitrant and harmful chemicals such as PFASs (per- and polyfluoroalkyl substances), endangers the environmental, wild-life, and human health profoundly.Amon...