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99,167 grants found
Showing 98,701 – 98,720 of 99,167 grants
Project 1: Megakaryocytes as Organizers of the Hematopoietic Environment
Insufficient megakaryopoiesis and thrombopoiesis remain the main cause of persistent thrombocytopenia after hematopoietic stem and progenitor cell (HSPC) transplantation and after...
Project 2: Extracellular Glycosylation and Blood Cell Production
Project 2 ? Project Summary Maintaining hematopoiesis is critical for life.Generating the proper numbers of functional blood cells across all lineages requires cell-intrinsic devel...
Project 3: Role of Glycosaminoglycans in Hematopoiesis
Project 3 ?Project Summary/Abstract Glycosaminoglycans (GAGs) contribute to myriad, and very often opposing, functions such as cellular proliferation as well as apoptosis, self-ren...
Improving Access and Affordability of Adult Hearing Healthcare: Effectiveness of Community-based Interventions in West Central and South Alabama
Abstract Mounting evidence suggests that hearing loss is associated with social isolation, depression and cognitive decline. Loss of hearing has become a growing public health conc...
Optimization of Lead BKIs for Cryptosporidiosis Therapy
ABSTRACT: Optimization of Lead BKIs for Cryptosporidiosis Therapy The broad, long-term objective of this research is to develop a therapeutic for treatment of Cryptosporidium infec...
Identifying the sequences and factors that govern the fate of elongating RNAPII
PROJECT SUMMARY: Precise control of gene expression during development and in response to signals is essential for organismal growth and homeostasis.Accordingly, gene expression is...
Genetic and molecular correlates of white matter pathology in Alzheimers disease
PROJECT SUMMARY: Although Alzheimer's disease (AD) is typically defined by the accumulation of beta- amyloid and hyperphosphorylated tau proteins, synaptic loss and neuronal d...
Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy
Project Summary: The long-term objective of this project is to develop a novel targeted therapy for human cancers by reactivating the tumor suppression pathways.Although p53 is fre...
Accounting for Hidden Bias in Vaccine Studies: A Negative Control Framework
Project Summary / Abstract The proposed research aims to develop novel causal inference methods to resolve unmeasured confounding bias known to plague vaccine effectiveness and saf...
Community Paramedicine Program to Improve Diabetes Management among Adults Experiencing Severe Hypoglycemia
PROJECT SUMMARY/ABSTRACT Severe hypoglycemia in the management of diabetes is associated with high morbidity, mortality, psychological distress, and impaired quality of life (QoL)....
Examining the effects of retinal cell loss on downstream visual brain areas
Because humans rely heavily on vision to experience the world, diseases of the eye are particularly debilitating in that they have significant adverse effects on patient health and...
MMACHC Regulates Craniofacial Development
cblC is a multiple congenital anomaly syndrome caused by mutations in the MMACHC gene. cblC is characterized by defects in cobalamin (vitamin B12) metabolism, but mild to moderate...
The role of the proximal nephron in salt-sensitive hypertension
The dramatic rise in U.S. fructose consumption mirrors the increase in the incidence of hypertension.More than 17 million Americans consume >20% of their calories as fructose an...
Mechanisms of Diabetes and Diabetic Complications in a Multi-Ethnic Population
ABSTRACT Racial and ethnic minority populations bear a disproportionate burden of diabetes and lifetime risk for diabetes-related complications in the United States, yet little is...
Safety and Cognitive Effects of Acute Intermittent Hypoxia-Induced Neuroplasticity in TBI
The purpose of this study is to determine whether Acute Intermittent Hypoxia (AIH) is safe to administer to medically stable chronic traumatic brain injury (TBI) patients. There is...
Synaptic mechanisms of auditory thalamic cross-modal communication
ABSTRACT Healthy subjects rapidly shift their attention in response to a dynamic sensory environment and changing cognitive demands.Failure to quickly shift perceptual resources be...
NON-NUCLEASE BASED GENE EDITING FOR HUTCHINSON-GILFORD PROGERIA
Project Summary There is substantial interest in gene editing as a means to treat human genetic disorders such as Hutchinson- Gilford Progeria Syndrome (HGPS).Much effort has been...
Activity-dependent regulation of Sonic hedgehog signaling incortical astrocytes
PROJECT ABSTRACT Understanding the mechanisms by which the CNS adapts to novel experiences and changing environments is a fundamental goal of neuroscience.Following experience and...
Combined Biomaterial and Neuromodulatory Approach to Promote Axonal Outgrowth and Connections After Cervical SCI
Spinal cord injury (SCI) interrupts connections between the motor cortex (MCX) and spinal motor circuits.We propose a novel approach to treat paralysis and weakness after spinal co...
DNA Topoisomerase Misfunctioning in Neurological Disease
DNA topoisomerase II (Top2) carries out changes in DNA structure needed for efficient transcription, replication, and DNA repair.This enzymes introduce transient double strand brea...