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99,167 grants found
Showing 98,681 – 98,700 of 99,167 grants
An engineered oncolytic herpes virus expressing a full-length α-CD47 mAb for the treatment of GBM
PROJECT SUMMARY ? PROJECT 1 The combination of oncolytic virotherapy (OV) and monoclonal antibody (mAb) immunotherapy has great potential for the treatment of glioblastoma (GBM), t...
Tasquinimod as an adjunct to immunotherapies administered peri-operatively
PROJECT SUMMARY ? PROJECT 2 Although immunotherapy has significantly improved patient survival for many types of cancers, to date no immunotherapeutic agent has shown consistent ef...
Signature-guided treatment of GBM with neddylation inhibitor pevonedistat
PROJECT SUMMARY ? PROJECT 3 The ubiquitin/proteasome system maintains intracellular homeostasis via degradation of unwanted proteins. Neddylation is a specific pathway within the u...
Administrative Core
PROJECT SUMMARY – Administrative Core This Duke/UT Southwestern Glioblastoma Therapeutics Network (GTN) team will complete pre-clinical development of a novel treatment for patie...
Biomarker, Bioinformatics and Biorepository Core
PROJECT SUMMARY – Biomarker, Bioinformatics and Biorepository Core The Duke/UT Southwestern Glioblastoma Therapeutics Network (GTN) team will complete pre-clinical development of...
6-thio-2'-deoxyguanosine in GBM: Pre-clinical Evaluation of Mechanism of action, Efficacy and Biomarker identification
PROJECT SUMMARY – Project 1 Gliomas are the most common primary malignant brain tumor in adults and account for over 14,000 deaths annually in the United States. The most common...
6-thio-2'-deoxyguanosine in GBM: Evaluation of Pharmaco-dynamics, Effects of Prior Standard of Care and A Human Phase 0 Study
PROJECT SUMMARY – Project 2 Glioblastoma (GBM) remains uniformly lethal, with an overall survival of <21 months despite standard of care therapies. Immunotherapy has remarkable e...
Administrative Core
PROJECT SUMMARY – ADMINISTRATIVE CORE The overall goal of the Administrative Core (Admin Core) is to provide the organizational infrastructure necessary to stimulate research and...
Analytical Immunopharmacology
PROJECT SUMMARY – CORE A The Analytical Immunopharmacology Core (Core A) is designed to meet the specific drug and biologic therapeutic development needs of each of the U19 Resea...
Molecular Profiling and Bioinformatics
PROJECT SUMMARY – CORE B The U19 Molecular Profiling and Bioinformatics Core (Core B) will provide state-of-the-art genomics and bioinformatics technology and expertise to advanc...
An engineered oncolytic herpes virus expressing a full-length α-CD47 mAb for the treatment of GBM
PROJECT SUMMARY – PROJECT 1 The combination of oncolytic virotherapy (OV) and monoclonal antibody (mAb) immunotherapy has great potential for the treatment of glioblastoma (GBM),...
Tasquinimod as an adjunct to immunotherapies administered peri-operatively
PROJECT SUMMARY – PROJECT 2 Although immunotherapy has significantly improved patient survival for many types of cancers, to date no immunotherapeutic agent has shown consistent...
Signature-guided treatment of GBM with neddylation inhibitor pevonedistat
PROJECT SUMMARY – PROJECT 3 The ubiquitin/proteasome system maintains intracellular homeostasis via degradation of unwanted proteins. Neddylation is a specific pathway within the...
Admin Core
ADMINISTRATIVE CORE PROJECT SUMMARY/ABSTRACT The primary objective of the Administrative (Admin) Core is to integrate, coordinate, and manage components of all components of ZAMBAM...
CETA-CORE
Project Summary/Abstract Unhealthy alcohol use is a major unaddressed barrier to control of the HIV epidemic in sub-Saharan Africa and the United States. The Zambia Alabama HIV Alc...
METHODS AND ANALYSIS CORE
Project Summary/Abstract Unhealthy alcohol use is a major unaddressed barrier to control of the HIV epidemic in sub-Saharan Africa and the United States. The Zambia Alabama HIV Alc...
CHARTZ
Project Summary/Abstract The intersection of unhealthy alcohol use and HIV infection is most significant in sub-Saharan Africa (SSA) where HIV prevalence exceeds 20% in some popula...
TALC
Project Abstract Alcohol use disorders, substance use disorders, and mental health comorbidities are a major threat to ending the HIV epidemic. This is especially the case in Alaba...
Administrative Core
ABSTRACT Tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide, and accounts for a third of the total number of deaths caused by HIV/AIDS. Unders...
Biostatistics and Data Management Resource Core
ABSTRACT The Biostatistics and Data Management (BDM) Core will play a pivotal role in the International Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on H...