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99,167 grants found
Showing 98,661 – 98,680 of 99,167 grants
Project 2: STAT3 as a trigger for T1D
Project Summary/Abstract Monogenic diseases that have a close association with the development of type 1 diabetes have been informative for unraveling critical pathways that keep...
Project 3: CRISPR Genome Editing to Understand and Correct STAT3 GOF Immune Dysregulation
Project Summary/Abstract Signal transducer and activator of transcription 3 (STAT3) gain of function (GOF) germline mutations are a monogenic cause of a syndrome of early-onset...
Project 1: FLASH vs. Standard radiotherapy for treatment of PDAC and sparing normal intestine tissues
SUMMARY (changes from previous submission denoted with shaded text ) Project 1 will test the overall hypothesis that Proton Radiotherapy delivered in ultra-fast dose rates (>60...
Project 2: Mitigation of radiation toxicity in treatment of sarcoma with FLASH vs. Standard dose rates
Project Summary Radiotherapy (RT) is used in the treatment of soft tissue sarcomas (STS), frequently in conjunction with surgical removal of gross disease. For pre-op RT, 50 Gy...
Project 3: Carbon and Electron FLASH radiotherapy for mitigation of normal lung injury in NSCLC
Summary Project 3 Late toxicity of thoracic irradiation limits curative treatment of lung cancer and compromises long-term life quality. Radiation induced lung fibrosis (RILF) is...
Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy
Project Summary This project will investigate spatio-temporal delivery of FLASH radiation using pencil beam scanning technology. Modern Pencil Beam Scanning (PBS) technology can...
Core A: Administrative Core
ABSTRACT (Core A) The Administrative Core (Core A) will provide support and effort coordination for each of the projects in this P01, as well as the three scientific cores. The a...
Core B: Physics-Dosimetry Core
Summary The central theme of this P01 is to investigate the role of proton/electron/carbon radiation dose rate in normal tissue damage and tumor killing. Delivery of precise dose...
Core C: Comparative Pathology Core
Project Summary The study of the preclinical animal models included in all four Projects plays a critical role to investigate the overall hypothesis that Proton/Carbon Particle F...
Core D: Biostatistics Core
Summary Core D aims to provide state of the art support for the biostatistics needs of the pre-clinical experiments proposed in the P01 Grant. Core D will work with project inves...
Virtual MOUD Treatment: Virtual Point-of-Care Toxicology Testing to Accompany Virtual Medication Assisted Treatment for Opioid Use Disorder
Background. Medication treatment of Opioid Use Disorder (MOUD) saves lives and is increasingly delivered virtually. Currently, 60% of VA outpatient addiction treatment occurs over...
Consortium for Viral Systems Biology Administrative Core
Project Summary / Abstract An e?cient administrative structure is essential to the design and implementation of the CViSB U19 Center. The Admin Core will be focused on...
Tasquinimod as an adjunct to immunotherapies administered peri-operatively
PROJECT SUMMARY – PROJECT 2 Although immunotherapy has significantly improved patient survival for many types of cancers, to date no immunotherapeutic agent has shown consistent...
Signature-guided treatment of GBM with neddylation inhibitor pevonedistat
PROJECT SUMMARY – PROJECT 3 The ubiquitin/proteasome system maintains intracellular homeostasis via degradation of unwanted proteins. Neddylation is a specific pathway within the...
An engineered oncolytic herpes virus expressing a full-length α-CD47 mAb for the treatment of GBM
PROJECT SUMMARY – PROJECT 1 The combination of oncolytic virotherapy (OV) and monoclonal antibody (mAb) immunotherapy has great potential for the treatment of glioblastoma (GBM),...
Biomarker, Bioinformatics and Biorepository Core
PROJECT SUMMARY – Biomarker, Bioinformatics and Biorepository Core The Duke/UT Southwestern Glioblastoma Therapeutics Network (GTN) team will complete pre-clinical development of...
6-thio-2'-deoxyguanosine in GBM: Pre-clinical Evaluation of Mechanism of action, Efficacy and Biomarker identification
PROJECT SUMMARY – Project 1 Gliomas are the most common primary malignant brain tumor in adults and account for over 14,000 deaths annually in the United States. The most common...
6-thio-2'-deoxyguanosine in GBM: Evaluation of Pharmaco-dynamics, Effects of Prior Standard of Care and A Human Phase 0 Study
PROJECT SUMMARY – Project 2 Glioblastoma (GBM) remains uniformly lethal, with an overall survival of <21 months despite standard of care therapies. Immunotherapy has remarkable e...
Analytical Immunopharmacology
PROJECT SUMMARY ? CORE A The Analytical Immunopharmacology Core (Core A) is designed to meet the specific drug and biologic therapeutic development needs of each of the U19 Researc...
Molecular Profiling and Bioinformatics
PROJECT SUMMARY ? CORE B The U19 Molecular Profiling and Bioinformatics Core (Core B) will provide state-of-the-art genomics and bioinformatics technology and expertise to advance...