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99,167 grants found
Showing 98,661 – 98,680 of 99,167 grants
Dynamics of protein kinase CK2 signaling in prostate cancer pathogenesis
Prostate cancer (PCa) is one of the major health issues for the aging Veterans population warranting investigations to further advance knowledge of the disease pathobiology and ben...
Structure and Function of Primate Retinal Circuits
An understanding of the normal structure and function of the retina is important to appreciate changes that occur during disease, development and aging.To this end, a longstanding...
The role of Bik in the replication and severity of influenza A virus
Influenza A virus (IAV) is responsible for seasonal epidemics that results in severe respiratory illness and deaths worldwide, costing billions of dollars annually in the U.S. alon...
Bioprintable composite materials and microfluidic tools for vocal fold restoration and repair
PROJECT SUMMARY/ABSTRACT: Voice disorders are among the most common communication disorders across the lifespan.Approximately 3- 9% of the general population, including children an...
Central Nervous System Plasticity in Airway Disease
PROJECT SUMMARY Exacerbations (asthma attacks) account for nearly one-third of all asthma deaths.Despite psychiatric illness as a risk factor for death from asthma, and many connec...
Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism
Multiple hypotheses have been put forward regarding cortical circuit dysfunction in autism, including: excitation to inhibition (E/I) imbalance, hyper- or hypo- connectivity profil...
Vascular calcification and atherosclerosis
Project Summary/Abstract Cardiovascular disease (CVD) is the leading cause of death in the U.S., with the annual total cost of care estimated at $351 billion.Vascular calcification...
Aspirin to prevent cardiac dysfunction in preeclampsia
ABSTRACT Preeclampsia (PE) is a disease of late pregnancy characterized by hypertension and organ damage, which not only increases peripartum morbidity but is associated with the p...
Traumatic Brain Injury and Vascular Disease
Objective: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the veteran population. In the United States, there are an estimated 5.3 million people livi...
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses
Retinal bipolar cells are the first 'projection neurons' of the vertebrate visual system and transmit all of the information needed for vision.Bipolar cells can signal ch...
Connecting AMD SNPs to Functions Using Allele-specific Interactions
PROJECT SUMMARY.Age-related Macular Degeneration (AMD) is a retinal neurodegenerative disease that is a major cause of vision loss among the elderly worldwide.Although anti-VEGF tr...
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins
Project Summary/Abstract Calcium activated Chloride Channels (CaCCs) and other TMEM16 family members form ion channels and/or lipid scramblases that help orchestrate a large number...
Mechanisms of RNA polymerase II transcription regulation
SUMMARY/ABSTRACT Our research program combines detailed biochemical reconstitution experiments with powerful cell-based assays, with a goal of gaining fundamental mechanistic insig...
Modeling the dynamic impact of rare and common genetic variation on gene expression and disease
Understanding the genetic basis of human disease will require a deep understanding of genetic effects on gene expression.The vast majority of disease-risk loci are non-coding, so i...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for molecu...
Regulatory mechanisms of the Hsp90 chaperone machinery
PROJECT SUMMARY The molecular chaperone Heat Shock Protein-90 (Hsp90) is essential for the folding and activity of an array of `client' proteins involved in signal transductio...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component.We carry out theoretical and computational...
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract.Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as decr...
Understanding and leveraging molecular diversity within the phytochrome superfamily
Understanding and leveraging molecular diversity within the phytochrome superfamily. Our proposal focuses on the phytochrome superfamily of photoreceptors.We have a longstanding in...
TAK1 signaling pathways
Abstract Innate immune signaling pathways are activated in response to exposure to microorganisms, and generally are effective in preventing pathogen invasion through inducing infl...