Browse All Grants
99,167 grants found
Showing 98,641 – 98,660 of 99,167 grants
Core C: Comparative Pathology Core
Project Summary The study of the preclinical animal models included in all four Projects plays a critical role to investigate the overall hypothesis that Proton/Carbon Particle F...
Core D: Biostatistics Core
Summary Core D aims to provide state of the art support for the biostatistics needs of the pre-clinical experiments proposed in the P01 Grant. Core D will work with project inves...
Project 1: FLASH vs. Standard radiotherapy for treatment of PDAC and sparing normal intestine tissues
SUMMARY (changes from previous submission denoted with shaded text ) Project 1 will test the overall hypothesis that Proton Radiotherapy delivered in ultra-fast dose rates (>60...
Project 2: Mitigation of radiation toxicity in treatment of sarcoma with FLASH vs. Standard dose rates
Project Summary Radiotherapy (RT) is used in the treatment of soft tissue sarcomas (STS), frequently in conjunction with surgical removal of gross disease. For pre-op RT, 50 Gy...
Project 3: Carbon and Electron FLASH radiotherapy for mitigation of normal lung injury in NSCLC
Summary Project 3 Late toxicity of thoracic irradiation limits curative treatment of lung cancer and compromises long-term life quality. Radiation induced lung fibrosis (RILF) is...
Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy
Project Summary This project will investigate spatio-temporal delivery of FLASH radiation using pencil beam scanning technology. Modern Pencil Beam Scanning (PBS) technology can...
Core A: Administrative Core
ABSTRACT (Core A) The Administrative Core (Core A) will provide support and effort coordination for each of the projects in this P01, as well as the three scientific cores. The a...
Core B: Physics-Dosimetry Core
Summary The central theme of this P01 is to investigate the role of proton/electron/carbon radiation dose rate in normal tissue damage and tumor killing. Delivery of precise dose...
Core C: Comparative Pathology Core
Project Summary The study of the preclinical animal models included in all four Projects plays a critical role to investigate the overall hypothesis that Proton/Carbon Particle F...
Core D: Biostatistics Core
Summary Core D aims to provide state of the art support for the biostatistics needs of the pre-clinical experiments proposed in the P01 Grant. Core D will work with project inves...
Impact of estradiol on the central regulation of glucose homeostasis and subsequent implications for hippocampal function.
Project 4 Summary Midlife obesity and diabetes mellitus (DM) are risk factors for all dementias including Alzheimer’s disease (AD), vascular cognitive impairment, and vascular de...
Resolving the Paradox of Hearing Complaints with a Normal Audiogram: Differential Diagnosis and Perceptual Impacts of Cochlear Deafferentation
Approximately 10% of Veterans with hearing complaints have clinically normal audiograms. Unfortunately, treatment options for these patients are limited and the outcomes are varia...
Testing a Novel Dry Electrode Headset for Electroencephalography Telehealth
Background: Many Veterans live far away from a VAMC with substantial electroencephalography (EEG) expertise. Travel is difficult for epilepsy patients since they often cannot driv...
Therapeutic hypothermia to preserve residual hearing in veterans receiving cochlear implantation
The primary goal of this proposal is to test and develop a novel application of therapeutic hypothermia for veterans receiving cochlear implantation (CI) with an aim to preserve r...
Investigate the mechanism of autoreactive B cell-mediated immunological failure despite virologic suppression in HIV-infected individuals on antiretroviral therapy
In HIV infection, circulating CD4+ T cell counts predict disease progression. Even under long-term suppressive antiretroviral therapy (ART), up to 25% of virologically suppressed...
Core B: Human Genetics and Genomics Core
Project Summary/Abstract The rapid growth in next generation sequencing techniques and proteomics has revolutionized the study of human disease, paving the way for the advent of...
Administrative Core
STAT3 Variants as a Rheostat of Immune Tolerance Administrative Core Project Summary A strong Project (P01) collaboration requires key centralized organizational structures to fo...
Core A: Mouse Core
STAT3 Variants as a Rheostat of Immune Tolerance Mouse Core Project Summary The use of genetically altered mice has revolutionized the study of complex biological processes, incl...
Core B: Human Genetics and Genomics Core
Project Summary/Abstract The rapid growth in next generation sequencing techniques and proteomics has revolutionized the study of human disease, paving the way for the advent of...
Project 1: Functional consequences of STAT3 GOF on immune cell signaling
Project Summary/Abstract Primary immune dysregulation syndromes are group of rare monogenic disorders affecting immune tolerance and leading to early-onset immunodeficiency, auto...