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99,167 grants found
Showing 98,641 – 98,660 of 99,167 grants
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...
Exploring cyclic di-nucleotide signaling across the tree of life (Supplement)
I am requesting support for the purchase of an Agilent BioTek LogPhase 600 microbiology plate reader through Notice NOT-GM-24-021 under the parent grant R35 GM139537-01, “Exploring...
Regulatory mechanisms of the Hsp90 chaperone machinery.
PROJECT SUMMARY The molecular chaperone Heat Shock Protein-90 (Hsp90) is essential for the folding and activity of an array of `client' proteins involved in signal transductio...
Understanding and leveraging molecular diversity within the phytochrome superfamily
Project Summary: Supplement for $7,016 for purchase of a spectroradiometer Understanding and leveraging molecular diversity within the phytochrome superfamily R35 GM139598; Princip...
Computational- and experimental- driven discovery of splicing regulation and circRNA function
Project Summary/Abstract Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcribe and process gene...
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively infl...
Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss
Abstract Hearing loss caused by noise, aging and chemotherapy affects seven hundred million people worldwide, but there are no FDA-approved drugs to prevent it. This research will...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in eukar...
Activity-Dependent Mechanisms of Memory Consolidation
PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learning...
Model Based Deep Learning Framework for Ultra-High Resolution Multi-Contrast MRI
Sensitive imaging biomarkers are urgently needed for screening of high?risk subjects, determine early disease progression, and assess response to therapies in neurodegenerative dis...
Intermuscular coherence: A novel biomarker for upper motor neuron dysfunction in ALS
Project Summary/Abstract Amyotrophic lateral sclerosis (ALS) is a uniformly fatal neurodegenerative disease caused by neuronal death in the motor system, both in the brain and spin...
The impact of G-quadruplexes on genome evolution
PROJECT SUMMARY Apart from the double-helix B-DNA structure discovered by Watson and Crick, approximately 13% of the human genome comprises sequence motifs that can form non-canoni...
Experimental and computational analysis of mechanisms of mitochondrial-cellular ROS crosstalk in the kidney in salt-sensitive hypertension
PROJECT SUMMARY Salt-sensitive hypertension is a significant health problem worldwide and there is a need to understand the underlying molecular mechanisms to enable more effective...
Mitochondrial pyruvate transport in retinal health and disease
PROJECT SUMMARY/ABSTRACT The retina is the most metabolically active neuronal tissue in the human body.The defect in the energy metabolism of photoreceptor neurons and their suppor...
Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer
PROJECT SUMMARY/ABSTRACT Development of effective therapies is an urgent unmet medical need for patients with metastatic gastroesophageal adenocarcinoma (mGEA).The advent of immune...
Nonlinear performance analysis and prediction for robust low dose lung CT
1 PROJECT SUMMARY / ABSTRACT 2 Nonlinear algorithms such as model-based reconstruction (MBR) and deep learning (DL) reconstruction have 3 sparked tremendous research interest in re...
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
PROJECT SUMMARY Our continued inability to develop selective therapies that prevent the emergence of disseminated breast tumor cells into lethal metastases necessitates new approac...
Role of ILC2 and eosinophils in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) affects 0.5~3.2% of the general populations in US and worldwide.Besides adjusting lifestyle, open surgery and endovascular stent grafting remain the...
Hydrogen peroxide in endothelial function and dysfunction
The proposed studies will use new biosensors and novel chemogenetic approaches to identify the molecular mechanisms whereby reactive oxygen species (ROS) regulate nitric oxide (NO)...
Dissecting Connectivity and Function of Transplanted Interneurons in the Injured Spinal Cord
Injury to the cervical spinal cord results in an immediate and permanent loss of hand function due to massive disruption of neural circuitry.There are currently no effective therap...