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99,167 grants found
Showing 98,481 – 98,500 of 99,167 grants
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
PROJECT SUMMARY/ABSTRACT Kidney disorders comprising acute kidney injury (AKI), chronic kidney disease (CKD) and end-stage renal disease (ESRD) account for significant morbidity...
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
Durable outcomes in subsets of solid cancer patients treated with immune checkpoint inhibitors (ICI) or adoptive cell transfer (ACT) immunotherapy has driven interest in gaining a...
Elucidation of a Eukaryotic Chemorepulsion Mechanism
The directed movement of eukaryotic cells away from a source of a chemorepellent appears to play a major role in development and the resolution of inflammation, but very little is...
Kidney PCSK9 in nephrotic syndrome
Summary / Abstract (max 30 lines): Nephrotic syndrome is a major manifestation of human glomerular disease, and patients with this condition develop large amounts of protein in t...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computati...
Optimization of Lead BKIs for Cryptosporidiosis Therapy
ABSTRACT: Optimization of Lead BKIs for Cryptosporidiosis Therapy The broad, long-term objective of this research is to develop a therapeutic for treatment of Cryptosporidium inf...
Temporal and Metabolic Regulation of Restimulation-Induced Cell Death (RICD) in Human T Cells
PROJECT SUMMARY/ABSTRACT PI: Snow, Andrew L. The healthy immune system depends upon a balance of proliferation and death of white blood cells, including B and T lymphocytes, to...
Connecting AMD SNPs to Functions Using Allele-specific Interactions
PROJECT SUMMARY. Age-related Macular Degeneration (AMD) is a retinal neurodegenerative disease that is a major cause of vision loss among the elderly worldwide. Although anti-VEG...
Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?
High IOP is a major causal risk factor for glaucoma and is the target of all current glaucoma therapies. This project investigates pathways that control intraocular pressure. Abno...
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense ag...
Oxylipin Signaling in Congenital Heart Disease
Project summary Congenital heart defects (CHD) constitute the most common type of congenital defect in humans, however the causes for CHD in most cases are unknown. Lipoxygenase-...
Adaptive population codes for flexible visually-guided behaviors
Summary/Abstract Active vision requires encoding and remembering relevant information based on current task goals. Classic accounts posit that sensory encoding, attentional sele...
Activity-Dependent Mechanisms of Memory Consolidation
PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learni...
Dissecting Connectivity and Function of Transplanted Interneurons in the Injured Spinal Cord
Injury to the cervical spinal cord results in an immediate and permanent loss of hand function due to massive disruption of neural circuitry. There are currently no effective ther...
SCH: Advancing Language-based Analyses of Social Media to Reliably Monitor Variation in Population
This proposal seeks to address a key challenge in public health : the ongoing and fine-grained measurement of population mental health. Currently, in the largest population survey...
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively in...
Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcification
PROJECT SUMMARY/ABSTRACT Vascular calcification, especially coronary artery calcification (CAC), is associated with increased risk of cardiovascular disease, whereas regular phys...
High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart
Project Summary Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subs...
Vascular calcification and atherosclerosis
Project Summary/Abstract Cardiovascular disease (CVD) is the leading cause of death in the U.S., with the annual total cost of care estimated at $351 billion. Vascular calcificat...
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotype
PROJECT SUMMARY Rapid evolutionary adaptation is a foundational process in biology and at the core of many issues facing humanity including cancer, bacterial and viral diseases,...