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99,167 grants found
Showing 98,421 – 98,440 of 99,167 grants
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract. Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as de...
Managing Cardiac Toxicities of Cancer Therapy
Project Summary This R35 application proposes to capitalize on previous work produced by the PI over the past 11 years and to further serve as a strong foundation for interrogati...
Development of biophysical approaches to investigate high-resolution structure and dynamics of membrane proteins
Abstract Functional reconstitution of membrane proteins has been the major roadblock for the application of NMR and other biophysical techniques to investigate their high-resolut...
Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
PROJECT SUMMARY Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has sprea...
Effectiveness of an Empirically Supported Family Intervention: Mental Health Outcomes, Mechanisms of Effect, and Organizational Factors
Project Summary/Abstract Cost-effective, brief programs to support family communication and improve mental health in youth are a pressing need; yet few evidence-based programs ex...
Community Action to Promote Healthy Environments
PROJECT SUMMARY The overarching goals of the Community Action to Promote Healthy Environments (CAPHE) partnership, established in 2014, are to: (1) develop new knowledge on local...
Synergistic Material-Microbe Interface towards Faster, Deeper, and Air-tolerant Reductive Dehalogenation
Project Summary/Abstract Challenges exist in bioremediation of halogenated contaminants, including low donor utilization efficiency and slow dehalogenation, low dehalogenation ac...
Applying and advancing modern approaches for studying the joint impacts of environmental chemicals on pregnancy outcomes
Preterm birth is a significant public health challenge due to increasing rates over time, as well as serious consequences for infant mortality, childhood morbidity, and economic c...
Microvascular mechanisms of growth restriction after environmental toxicant exposure
ABSTRACT The uterine circulation and placenta are specifically designed to regulate the flow of blood and transport of es- sential nutrients to the fetus. Disruption of maternal...
Model-aided Design and Integration of Functionalized Hybrid Nanomaterials for Enhanced Bioremediation of Per-and Polyfluoroalkyl Substances (PFASs)
PROJECT SUMMARY Environmental contamination by per- and polyfluoroalkyl substances (PFASs) is a major public health concern because of the wide range of toxic effects that have b...
Efficient Bioremediation of Environmentally Persistent Contaminants with Nanomaterial-Fungus Framework (NFF)
Project Summary The recalcitrant and harmful chemicals such as PFASs (per- and polyfluoroalkyl substances), endangers the environmental, wild-life, and human health profoundly. A...
Enhancing bioremediation of groundwater co-contaminated by chlorinated volatile organic compounds and 1,4-dioxane using novel macrocyclic materials
Project Summary The project addresses a common challenge in the remediation of groundwater contaminated with chlorinated volatile organic compounds (CVOCs) and 1,4-dioxane. CVOC...
Cell cycle dependent mechanisms triggering lumen formation in vivo
SUMMARY STATEMENT: In humans and other vertebrates, motile cilia located in an organ of asymmetry play an important role in cardiac left-right development. Evidence from model org...
The Epitranscriptome as a Novel Mechanism of Arsenic-Induced Diabetes.
SUMMARY In the United States, the prevalence of type 2 diabetes mellitus (T2DM) is particularly high among American Indian (AI) communities. Arsenic (As), a pervasive environment...
Multiethnic genomic epigenomic and transcriptomic fine-mapping and functional validation analysis of schizophrenia and bipolar disorder risk loci
PROJECT SUMMARY Serious mental illness (SMI) that includes schizophrenia (SCZ) and bipolar disorder (BD) are common, complex and debilitating psychiatric disorders that together...
Fine-Mapping Genome-Wide Associated Loci using Multi-omics Data to Identify Mechanisms Affecting Serious Mental Illness
Genome-wide association studies have been key for identifying genetic variation associated with psychiatric disorders. Whenever these GWAS are based on large sample sizes, however...
Predicting and Preventing Ventilator-Induced Lung Injury
Project Summary Acute respiratory distress syndrome (ARDS) is a rapid onset respiratory failure that is caused by factors ranging from pneumonia to sepsis. The impact of ARDS is...
Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss
Abstract Hearing loss caused by noise, aging and chemotherapy affects seven hundred million people worldwide, but there are no FDA-approved drugs to prevent it. This research wil...
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning....
Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy
Project Summary: The long-term objective of this project is to develop a novel targeted therapy for human cancers by reactivating the tumor suppression pathways. Although p53 is...