Browse All Grants
99,167 grants found
Showing 98,341 – 98,360 of 99,167 grants
Optimizing Colorectal Cancer Screening among Patients with Diabetes in Safety-Net Primary Care Settings: Targeting Implementation Approaches
ABSTRACT Patients with diabetes mellitus have an estimated 27% elevated risk of developing colorectal cancer (CRC) and are disproportionately Non-Hispanic blacks (NHBs) and Hispa...
Targeting polyamines to suppress SARS-CoV-2 related disease
ABSTRACT The pandemic COronaVIrus disease 2019 (COVID-19) is an infectious disease, which is caused by a novel and highly pathogenic virus strain SARS-CoV-2 (Severe acute respira...
The role and mechanistic regulation of cPLA2alpha in eicosanoid biosynthesis and wound healing
In recent years, new technological advancements in small molecule analyses (e.g., lipidomics) have identified a biochemical manifestation of impaired wound healing: the developmen...
MicroRNA Function During Neuronal Reprogramming in Treating Spinal Cord Injury
Project Summary: One major obstacle in treating spinal cord injury (SCI) is to replenish neurons that are lost during the course of injury and to restore local neuronal circuitry...
Role of skin injury-induced inflammation in wound healing
PROJECT SUMMARY Chronic skin wounds like diabetic foot ulcers (DFU) are a serious medical problem in Veterans. Up to one third of patients with diabetes develop DFU, a leading ca...
Effect of Gut Microbiome Dysbiosis in the Pathobiology of Multiple Sclerosis
Despite the association between gut microbiota and multiple sclerosis (MS) being increasingly appreciated, the mechanism through which gut bacteria and their metabolites modulate...
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
ABSTRACT Despite substantial experimental evidence for the important functional role of myeloid-biased HSC (myHSC) in stress, inflammation and aging, the mechanisms which control...
Assessment of EEG Responses to Spinal Cord Stimulation Waveforms in Chronic Pain Patients
Chronic pain is a significant problem and it has been estimated to affect about 50 million adult Americans. It accounts for more than 600 billion dollars in health care expenditure...
hiPS cells derived skeletal muscle progenitors and their extracellular vesicles for treatment of sarcopenia
PROJECT SUMMARY Aging of skeletal muscle results in sarcopenia. It is believed that sarcopenia is in part due to a decreased capacity of stem cells, namely satellite cells, to re...
X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research
PROJECT SUMMARY/ABSTRACT Over the past 10 years, our group has made multi-disciplinary efforts to bridge the technological gap between radiation methods for human treatment and p...
Delineating epigenetic coordination of regenerative cell plasticity
Delineating epigenetic coordination of regenerative tissue plasticity Abstract: Tissue damage and repair represent fundamental problems in human health for which few pharmacologi...
Employing functionalized fragment libraries to identify therapeutic agents for neurofibromatosis type 2
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease with the most common manifestation being development of bilateral schwannomas of the 8th cranial nerve (...
Using Genetic Diversity to Manage Neurological Disease
Project Summary/Abstract: This one-year Administrative Supplement request in response to NOT-AG-22-025/PA-20-272 is a proposal to use our state-of-the-art Gaussian Process (GP) m...
Retinal Mitochondrial Metabolism in Alzheimer's Disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the leading cause of dementia. Effective treatment and tests for early diagnosis are still not available. AD patients often h...
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses.
Project Abstract Dementias, including those associated with Alzheimer's disease (AD), are major neurodegenerative disorders that cause visual problems due to pathologic changes i...
Mitochondrial calcium overload and necrosis in tauopathies caused by inhibition of Mfn2 and NCLX
Abstract Tau aggregates (also known as neurofibrillary tangles or NFTs) are hallmarks of the neurodegenerative diseases collectively known as tauopathies. These diseases are a br...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic...
Optimizing sleep spindle measurements as translational assays of memory consolidation
This research proposal addresses a key challenge to drug development: the paucity of biomarkers that reveal whether interventions affect implicated brain circuitry at early stages...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated varian...
Synthesis and Characterization of Nitrogen and Sulfur Donor-Acceptor Stenhouse Adducts
Project Summary/Abstract This proposal describes the use of fundamental chemical properties to alter the reactivity of reagents for the synthesis of biomedically important compo...