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99,167 grants found
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Combining modeling and experiments to study the evolution of cells with altered ploidy
Project Summary Aneuploidy is a ubiquitous feature of cancer cells, and accumulation of aneuploidy is believed to often happen via tetraploidization (genome doubling) as an interme...
Modeling the dynamicimpact of rare and common genetic variation on gene expression anddisease
Understanding the genetic basis of human disease will require a deep understanding of genetic effects on gene expression. The vast majority of disease-risk loci are non-coding, so...
Allorecognition, parasitic stem cells and regeneration in a basal chordate
Abstract Our lab works at the intersection of immunology, stem cell biology and regeneration, and the grants funding this work (GM123267 and GM 123255) which we are requesting to m...
Developing nonmuscle myosin II inhibitors for the treatment of glioblastoma
PROJECT SUMMARY An area of significant unmet need is the treatment of glioblastoma (GBM), an aggressive, fast-growing and lethal brain cancer that represents 15% of all brain tumor...
Developmental underpinnings of substantia nigra vulnerability
Abstract: DA neuron degeneration, resulting in deficient DA signaling, underpins the debilitating motor symptoms of Parkinson’s disease (PD). Among DA neurons, those located in ven...
Fluid shear stress mechanotransduction at endothelial cell-cell junctions
Project Summary This project aims to understand in molecular detail how fluid shear stress acting on endothelial cells triggers mechanical activation of signaling pathways at cell-...
RNA Nanosystem for Posterior Eye Drug Delivery
RNA nanotechnology provides molecules that have the simplicity in design with the characteristics of DNA and can be used in therapies. However, a major problem in RNA nanotechnolog...
DNA-based Immune Phenotyping in HNSCC for Biomarkers of Response to Immunotherapy
PROJECT SUMMARY/ABSTRACT Head and Neck Squamous Cell Carcinomas (HNSCCs) are devastating upper airway tumors that are associated with an immunosuppressive network impacting the tum...
Gene regulatory networks for heart development
PROJECT SUMMARY Congenital heart defects (CHDs) are the most prevalent and serious birth defects, occurring in over 1% of live births. Major subsets of congenital heart defects are...
Computational- and experimental- driven discovery of splicing regulation and circRNA function
Project Summary/Abstract Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcribe and process gene...
Strategic Molecular Activations for the Selective Synthesis of 2-Deoxy-Beta-Glycosides, and for the Synthesis of Novel Donor-Acceptor Stenhouse Adducts
Project Summary/Abstract This proposal describes the use of fundamental chemical properties to alter the reactivity of reagents for the synthesis of biomedically important compound...
Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of...
Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD
Only sertraline and paroxetine are currently FDA‐approved to treat PTSD. Other psychotropics are equally limited to provide optimal respond. This efficacy gap may be particularly g...
Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.
Parkinson’s Disease (PD) is a common neurodegenerative disorder affecting human movements. PD is not just a motor disease. It also results in impaired multi-sensory processing that...
Base editing and prime editing for sickle cell disease
PROJECT SUMMARY Despite advances in the medical care of sickle cell disease (SCD), most patients continue to experience severe pain, poor quality of life, progressive organ deterio...
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Project Summary/Abstract Alzheimer’s disease (AD) is characterized by heterogeneity in sex, race, APOE ε4 status, and tau. APOE ε4 status has been used to stratify AD patients in c...
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
PROJECT SUMMARY Early detection of lung cancer among asymptomatic individuals is a priority for reducing mortality of the number one cancer killer worldwide. Most lung cancers are...
Transcriptional control of retinal neuron specification and maturation.
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguished...
Ligand discovery for delineating cholesterol homeostasis in the brain
Alzheimer’s disease (AD) is a long-term neurodegenerative disorder that ranks sixth in the leading cause of all deaths in the United States and features amyloid β protein depositio...
The Effects of Early Psychosocial Deprivation on Cardiometabolic Risk in Early Adulthood
Project Summary/Abstract The Bucharest Early Intervention Project (BEIP)—the only randomized controlled trial (RCT) comparing foster care to institutional care for young children—w...