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99,167 grants found
Showing 98,241 – 98,260 of 99,167 grants
Identifying the sequences and factors that govern the fate of elongating RNAPII
PROJECT SUMMARY: Precise control of gene expression during development and in response to signals is essential for organismal growth and homeostasis. Accordingly, gene expression...
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine
PROJECT SUMMARY: Inflammatory bowel disease (IBD) is an increasingly prevalent disease that currently affects ~1.3% of adults in the US. IBD is characterized by chronic inflammato...
Mitochondrial 2-hydroxyglutarate dehydrogenases modulate the cellular epitranscriptome
There is increasing recognition of mitochondria as signaling organelles. An important facet of this “adjunct” mitochondrial function is epigenetic modulation, as exemplified by th...
Community Care Utilization among Post-9/11 Veterans with Traumatic Brain Injury
Background: Estimates suggest that 20% or more of Post-9/11 Veterans have experienced at least one military-related traumatic brain injury (TBI); the majority are categorized as m...
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
Project Summary/Abstract The overall theme of my research program is to understand the formation mechanism of chromatin structure and its role in gene regulation. We plan to addr...
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level
Project Summary/Abstract Heart failure (HF) is a growing cause of morbidity and mortality. Despite the best available treatments, prognosis remains poor for many HF patients und...
Synaptic mechanisms of auditory thalamic cross-modal communication
ABSTRACT Healthy subjects rapidly shift their attention in response to a dynamic sensory environment and changing cognitive demands. Failure to quickly shift perceptual resources...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc...
The role of Bik in the replication and severity of influenza A virus
Influenza A virus (IAV) is responsible for seasonal epidemics that results in severe respiratory illness and deaths worldwide, costing billions of dollars annually in the U.S. alo...
A system for long-term high-resolution 3D tracking of movement kinematics in freely behaving animals
PROJECT SUMMARY The aim of this proposal is to deliver an innovative and easy-to-use experimental platform for measuring and quantifying naturalistic behaviors of mammalian anima...
Traumatic Axonopathy in the CNS as Wallerian degeneration
PROJECT SUMMARY In this application we propose that traumatic axonal injury (TAI) leads to an active axonopathy with the molecular features of Wallerian degeneration and that tar...
Estrogen Receptor Signaling in the Expression of Respiratory Motor Plasticity
PROJECT SUMMARY/ABSTRACT The respiratory control system displays a remarkable capacity for neuroplasticity, imparting flexibility of breathing in response to changing physiologic...
Understanding and targeting bone marrow microenvironment in myelofibrosis
Project summary/Abstract Understanding and targeting abnormal tumor microenvironment is critically important for developing effective therapy. Primary myelofibrosis (PMF) is a fo...
cryoEM Studies of Muscle
Project Summary The long term goal of this research project has been and continues to be an understanding of the molecular mechanism of muscle function. The existing project, fun...
New Statistical Methods for Modelling Cancer Outcomes
PROJECT SUMMARY/ABSTRACT Lung cancer is one of the most common causes of mortality worldwide. Radiomic features have been shown to provide prognostic values in predicting lung ca...
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA struc...
Action of Lipolytic Enzymes
PROJECT SUMMARY/ABSTRACT The overall goal of this grant in recent years has been to describe in molecular detail the mechanism of action of physiologically important human forms...
CCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastoma
PROJECT SUMMARY Brain tumors are the most common solid tumor and the leading cause of cancer-related death in children. Medulloblastoma (MB) is the most common malignant pediatri...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in respons...
Impact of brain estrogens on cognition and brain aging in a non-human primate
SUMMARY Aromatase inhibitors (AIs) are drugs that inhibit estrogen synthesis and that are prescribed to prevent the recurrence of estrogen responsive breast cancers. However, AI...