Browse All Grants
99,167 grants found
Showing 98,201 – 98,220 of 99,167 grants
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
Project Summary: There is a rapidly growing body of evidence that Müller glia can are a source of retinal progenitors to promote neural regeneration. Many studies have demonstrate...
Role of membrane-associated macrophages in health and inflammation
PROJECT SUMMARY/ ABSTRACT Mesenteritis is an inflammatory disorder of mesenteric tissues. It includes mesenteric lipodystrophy (mesenteric fat necrosis), mesenteric panniculitis...
Molecular mechanistic studies of long “noncoding” RNAs in mammalian cell differentiation
PROJECT SUMMARY The goal of this study is to determine the molecular mechanisms by which long “noncoding” RNAs regulate mammalian cells differentiation. Long noncoding RNAs (lncR...
RNA Nanosystem for Posterior Eye Drug Delivery
RNA nanotechnology provides molecules that have the simplicity in design with the characteristics of DNA and can be used in therapies. However, a major problem in RNA nanotechnolo...
Precise assembly of retinal circuitry through rejection of inappropriate synaptic partners
During development, retinal neurons make exquisitely precise connections with specific synaptic partners. These synaptic choices impact the computational capacity of retinal circu...
Mechanisms of retinal degeneration in neuroinflammatory demyelinating diseases
An important question in the field of multiple sclerosis (MS) is whether myelin/axonal damage in the white matter facilitates neuronal cell body loss in the gray matter, or result...
The regulation and function of long non coding RNA in ischemic AKI: Role of GSTM3P1
Summary: Acute kidney injury (AKI) is a major renal disease that can be caused by ischemia, sepsis, urinary obstruction and nephrotoxins. It is associated with high mortality cli...
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
This proposal brings together a unique interdisciplinary team with complementary expertise in high-LET radiobiology, pancreatic cancer research, and high-LET physics. It leverages...
Exploiting sex-dependent brain injury response for nanoparticle therapeutics
Abstract Traumatic brain injury (TBI) afflicts over 1.7 million persons per year in the U.S. alone, resulting in substantial economic burden annually. To date, despite promising...
Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury
Sepsis accounts for nearly 50% of acute kidney injury (AKI) in the intensive care unit and significantly impacts mortality. However, therapy for sepsis-associated AKI (SA-AKI) has...
SARM1 functional polymorphisms and their contribution to ALS risk
Motor axon loss is a cardinal symptom of amyotrophic lateral sclerosis (ALS). Axon loss can be driven by a genetically encoded program in which the axon survival factors NMNAT2 an...
Structural Biology of Dopamine Signaling
Abstract Human dopamine signaling pathway induces and facilitates dopamine neurotransmission through the mesolimbic dopaminergic pathway, which modifies reward-related behaviors...
Central Nervous System Plasticity in Airway Disease
PROJECT SUMMARY Exacerbations (asthma attacks) account for nearly one-third of all asthma deaths. Despite psychiatric illness as a risk factor for death from asthma, and many con...
The role and mechanistic regulation of cPLA2alpha in eicosanoid biosynthesis and wound healing
In recent years, new technological advancements in small molecule analyses (e.g., lipidomics) have identified a biochemical manifestation of impaired wound healing: the developmen...
Developmental Regulation of Gene Expression by Long Undecoded Transcript Isoforms
PROJECT SUMMARY Dynamic gene expression programs drive essential biological processes including cellular differentiation and stress response pathways. During these processes, cel...
A Leukemia Cell-Specific Coiled-Coil Protein for Treatment of Chronic Myeloid Leukemia
Project Summary/Abstract The long-term goals of this proposal are to explore the protein dimerization interface as an area for therapeutic intervention. Protein dimerization/olig...
Using Genetic Diversity to Manage Neurological Disease
Project Summary/Abstract Understanding and treating genome abnormalities that lead to rare genetic neurodegenerative diseases such as Niemann-Pick C1 globally managing cholestero...
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infection
PROJECT SUMMARY: Zika virus (ZIKV) is a teratogenic human pathogen that causes congenital eye and brain diseases. Affected babies exhibit vision impairment and associated ocular p...
Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer
PROJECT SUMMARY/ABSTRACT Development of effective therapies is an urgent unmet medical need for patients with metastatic gastroesophageal adenocarcinoma (mGEA). The advent of imm...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in euk...