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Structural Biology of Dopamine Signaling
Abstract Human dopamine signaling pathway induces and facilitates dopamine neurotransmission through the mesolimbic dopaminergic pathway, which modifies reward-related behaviors an...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Known modifiable risk factor...
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infection
PROJECT SUMMARY: Zika virus (ZIKV) is a teratogenic human pathogen that causes congenital eye and brain diseases. Affected babies exhibit vision impairment and associated ocular pa...
Epigenomics of asthma risk factors and clinical subtypes in minority children
PROJECT SUMMARY Asthma is the most common chronic disorder of children, with an estimated 300 million cases worldwide and with significant increases in incidence since the early 19...
Development of biophysical approaches to investigate high-resolution structure and dynamics of membrane proteins
Abstract Functional reconstitution of membrane proteins has been the major roadblock for the application of NMR and other biophysical techniques to investigate their high-resolutio...
Dynamics, Regulation and Function of p53 in Single Cells
The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes. The tumor suppressor protein p53 is a transcription factor orchestrat...
Soft drusen in rhesus macaques as a nonhuman primate model of early age-related macular degeneration
PROJECT SUMMARY Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, but current treatments target advanced stages when interventions may be l...
Gene regulatory networks for heart development
PROJECT SUMMARY Congenital heart defects (CHDs) are the most prevalent and serious birth defects, occurring in over 1% of live births. Major subsets of congenital heart defects are...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic ou...
Community Action to Promote Healthy Environments
PROJECT SUMMARY The overarching goals of the Community Action to Promote Healthy Environments (CAPHE) partnership, established in 2014, are to: (1) develop new knowledge on local c...
Highly Selective Catalytic Reactions of Alkenes and Alkynes Relevant to Medicinal and Process Chemistry
Project Summary/Abstract A recent critical analysis of biologically active molecules and reactions most often used for their preparation suggests that fraction of saturated carbon...
Role of mitophagy in age-related respiratory and vascular diseases
PROJECT SUMMARY/ABSTRACT The overarching theme of my research program is to understand how innate immunity enhances age- associated cardiovascular and pulmonary diseases. As a phys...
Deciphering principles of network dynamics underlying depression symptom severity from multi-day intracranial recordings in patients with major depression
PROJECT SUMMARY/ABSTRACT Major depressive disorder (MDD) is common and causes significant disability world-wide. While typically responsive to medications and therapy, there remai...
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease Principal Investigators: Chong Wu, Ph.D. (contact); Jonathan Bradley, Ph.D. Summary A fundamental...
Developing novel CRISPR/CasX editors to generate a CCR5/null immune system
The characterization of CRISPR/Cas as a method to edit genes that contribute to human diseases provides new opportunities for the development of innovative therapeutic approaches....
The Impact of Aging on Prostate Cancer with Age-Related Disruption of Th17/Treg Axis
Project Summary/Abstract: Prostate cancer (PCa) is particularly important in elderly men because of the high incidence and prevalence of disease and mortality in this group of pat...
Historic Violence and Contemporary Racial Disparities in Birth Outcomes
Abstract Racism and racist structures shape the social environment for all Americans, although the durable imprint of place on health and health disparities remains underexamined....
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Project Summary/Abstract Alzheimer?s disease (AD) is characterized by heterogeneity in sex, race, APOE ?4 status, and tau. APOE ?4 status has been used to stratify AD patients in c...
Employing functionalized fragment libraries to identify therapeutic agents for neurofibromatosis type 2
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease with the most common manifestation being development of bilateral schwannomas of the 8th cranial nerve (V...
Ligand discovery for delineating cholesterol homeostasis in the brain
Alzheimer?s disease (AD) is a long-term neurodegenerative disorder that ranks sixth in the leading cause of all deaths in the United States and features amyloid ? protein depositio...