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99,167 grants found
Showing 98,101 – 98,120 of 99,167 grants
Normalizing aberrant metabolism in ovarian cancer by a unique drug delivery system
Gene silencing using small interfering RNA (siRNA) is a viable therapeutic approach but, limited in translation due to lack of effective delivery systems. Developing effective and...
Influence of Opioids on the Brainstem Respiratory Network
PROJECT SUMMARY Many of the 54,000 opioid-related deaths in 2017 were due to respiratory depression. The specific mechanisms by which opioids depress breathing are not fully unde...
Development of Asymmetric Cooperative Gold Catalysis and Beyond
Cooperative catalysis or catalysis involving metal-ligand cooperation is a highly versatile approach in catalysis that have resulted in a myriad of highly efficient synthetic meth...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic...
Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer
PROJECT SUMMARY/ABSTRACT Development of effective therapies is an urgent unmet medical need for patients with metastatic gastroesophageal adenocarcinoma (mGEA). The advent of imm...
Soft drusen in rhesus macaques as a nonhuman primate model of early age-related macular degeneration
PROJECT SUMMARY Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, but current treatments target advanced stages when interventions may be...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for mol...
Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2D
Abstract Charcot-Marie-Tooth (CMT) disease type 2D is caused by dominant mutations in GARS, encoding glycyl-tRNA synthetase (GlyRS). CMT is a clinically and genetically heterogen...
New Statistical Methods for Modelling Cancer Outcomes
PROJECT SUMMARY/ABSTRACT Lung cancer is one of the most common causes of mortality worldwide. Radiomic features have been shown to provide prognostic values in predicting lung ca...
Molecular mechanisms of excitatory postsynaptic diversity
Unique patterns of synaptic connectivity between neurons, and the differential strength of those synapses, are fundamental to the information processing capability of the brain. S...
Regulating transcription of the key neural lineage driver ASCL1
The bHLH transcription factor ASCL1 (HASH1/MASH1) is essential for neuronal differentiation and sub-type specification of multiple neuronal cell-types throughout the brain, spinal...
Exploring cyclic di-nucleotide signaling across the tree of life
Scope of Work This administrative supplement will support Dr. Nkrumah Grant for a postdoctoral position in the Waters laboratory at Michigan State University. Dr. Grant will perf...
Optimizing Colorectal Cancer Screening among Patients with Diabetes in Safety-Net Primary Care Settings: Targeting Implementation Approaches
ABSTRACT Patients with diabetes mellitus have an estimated 27% elevated risk of developing colorectal cancer (CRC) and are disproportionately Non-Hispanic blacks (NHBs) and Hispa...
Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy
Project Summary Recently, we discovered that adoptive transfer of CD39KO tumor-specific (mixed CD4+ and CD8+) T cells, resulted in long-term survival of mice bearing large establ...
Structural Biology of Dopamine Signaling
Abstract Human dopamine signaling pathway induces and facilitates dopamine neurotransmission through the mesolimbic dopaminergic pathway, which modifies reward-related behaviors...
Identifying primary targets of bumped kinase inhibitor derived compounds to improve utility as therapy for castration resistant prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer (CRPC) that inevitably escapes primary therapies most often retains dependency on androgen receptor (AR). We are repos...
Neurally targeted group intervention to reduce early childhood anxiety
Clinically significant anxiety affects 20% of preschoolers and can become chronic, leading to depression, substance abuse, school-drop out and even suicide. To reduce anxiety and p...
Harnessing acid-sensing ion channel toxins for therapeutic purposes
PROJECT SUMMARY/ABSTRACT Generalized anxiety and panic disorder are debilitating disorders resulting in severe social and economic impact for patients. Antidepressants and benzodi...
2/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT DESCRIPTION The goal of this international collaborative project, in response to PAR-20-027, is to characterize the genetic architecture of schizophrenia in the Xhosa popul...