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99,167 grants found
Showing 98,081 – 98,100 of 99,167 grants
Core A: Administrative Core
Administrative Core - Project Summary/Abstract The Administrative Core is located within the administrative offices of the Blood Research Institute (BRI), the research arm of Versi...
Core B: Glyco-genomics and Bioinformatics
Core B - Project Summary/Abstract This Program Project will investigate the mechanisms by which glycosylation and glycans may alter the function, maintenance, differentiation, and...
Core C: GAGomics and Proteomics
Core C – Project Summary/Abstract Glycosaminoglycans (GAGs) are linear O-linked polysaccharides that modify serine residues for a select number of membrane proteins (e.g., glypican...
Project 1: Megakaryocytes as Organizers of the Hematopoietic Environment
Insufficient megakaryopoiesis and thrombopoiesis remain the main cause of persistent thrombocytopenia after hematopoietic stem and progenitor cell (HSPC) transplantation and after...
Project 2: Extracellular Glycosylation and Blood Cell Production
Project 2 – Project Summary Maintaining hematopoiesis is critical for life. Generating the proper numbers of functional blood cells across all lineages requires cell-intrinsic deve...
Uncovering associations of variant infection with COVID-19 disease severity in children
Project Abstract Under parent grant R61HD105618 (PI Chiu, University of California, San Francisco), we proposed to define panels of diagnostic and predictive host markers of COVID-...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability. In response to DNA damage, the cell activates several evolut...
Discovery and development of artificial nucleic acid ligands to probe cellular interactions
Discovery and development of artificial nucleic acid ligands to probe cellular interactions The regulation followed by measurement of cellular events, such as intercellular communi...
Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism
Multiple hypotheses have been put forward regarding cortical circuit dysfunction in autism, including: excitation to inhibition (E/I) imbalance, hyper- or hypo- connectivity profil...
SCH: Context-Aware Freezing of Gait Mitigation in Real-World Setting
See attached. RELEVANCE (See instructions): See attached.
Strategic Molecular Activations for the Selective Synthesis of 2-Deoxy-Beta-Glycosides, and for the Synthesis of Novel Donor-Acceptor Stenhouse Adducts
Project Summary/Abstract This proposal describes the use of fundamental chemical properties to alter the reactivity of reagents for the synthesis of biomedically important compound...
Surfactant Protein C Mouse Models: A Fit For Purpose Preclinical Platform For Advancing Discovery In And Treatment Of Idiopathic Pulmonary Fibrosis
ABSTRACT Idiopathic Pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) of older adults characterized by disruption of distal lung architecture that ultimatel...
High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart
Project Summary Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subseq...
Molecular Mechanisms of HFpEF-associated Atrial Fibrillation
PROJECT SUMMARY It is said that heart failure with preserved ejection fraction (HFpEF) is the single greatest unmet need in cardiovascular medicine. Patients with HFpEF are uniquel...
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome. To reduce this burden, most organisms have evolved sophisti...
Disparities in the Use of Oral Anticancer Agents in Kidney Cancer
We have long known that real-world black-white racial disparities have existed in the treatment and outcomes of patients with renal cell carcinoma (RCC). However, it is unclear how...
Proteomic determinants of response to checkpoint blockade in malignant pleuralmesothelioma
PROJECT SUMMARY / ABSTRACT Malignant pleural mesothelioma (MPM) is a fatal cancer of the lining of the lungs that has defeated standard therapies for decades. Immune checkpoint inh...
Testing a culturally targeted narrative video to reduce disparities in the use of genetic counseling and testing in Latina women at-risk of HBOC
ABSTRACT National guidelines recommend that women at increased risk for Hereditary Breast and Ovarian Cancer (HBOC) due to BRCA1/2 mutations be referred for genetic counseling and...
Dynamics, Regulation and Function of p53 in Single Cells
The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes. The tumor suppressor protein p53 is a transcription factor orchestrat...
Understanding the function of histone H3 as an oxidoreductase enzyme
PROJECT SUMMARY This application proposes to investigate the newly discovered function of histone H3 as an oxidoreductase enzyme, catalyzing the reduction of cupric (Cu+2) ions to...