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99,167 grants found
Showing 98,061 – 98,080 of 99,167 grants
Experience-dependent Cellular Plasticity Mechanisms
Brain activity is essential for the development and plasticity of neurons and circuits, however our understanding of the mechanisms by which activity generates functional circuits...
Optimization of Lead BKIs for Cryptosporidiosis Therapy
ABSTRACT: Optimization of Lead BKIs for Cryptosporidiosis Therapy The broad, long-term objective of this research is to develop a therapeutic for treatment of Cryptosporidium inf...
Direct chemical control of the hematopoietic master transcription factor PU.1
PROJECT SUMMARY/ABSTRACT: Direct control of the hematopoietic master transcription factor PU.1 Hematopoiesis, the process by which all lineages of blood cells are derived, is unde...
ERβ repurposes EZH2 to suppress oncogenic NFκB signaling in TNBC
PROJECT SUMMARY/ABSTRACT Breast cancer remains the most commonly diagnosed cancer in women and is the second leading cause of cancer-related deaths among women. Triple Negative B...
Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos
Latinos are the fastest growing subpopulation of older adults in the U.S.A. and have a greater prevalence of Alzheimer’s disease (AD) than non-Latino whites (1). Despite this, our...
Probing cytosolic nucleic acid sensing pathways in cancer
ABSTRACT The ability of mammalian cells to elicit inflammation is central to many processes including embryogenesis, wound healing, tissue regeneration, and cancer metastasis. A...
Uptake and Patterns of Use of the IQOS Heated Tobacco System by US Smokers
Project Abstract On April 30, 2019, the U.S. Food and Drug Administration (FDA) issued a marketing order authorizing the IQOS “Tobacco Heating System” (IQOS), manufactured by Phi...
Abscission regulation of corticogenesis
Abstract: In order for the brain to develop with proper size and structure, neural stem cells (NSCs) at early ages must make proliferative divisions and maintain their stemness to...
Elucidation of a Eukaryotic Chemorepulsion Mechanism
The directed movement of eukaryotic cells away from a source of a chemorepellent appears to play a major role in development and the resolution of inflammation, but very little is...
Aspirin to prevent cardiac dysfunction in preeclampsia
ABSTRACT Preeclampsia (PE) is a disease of late pregnancy characterized by hypertension and organ damage, which not only increases peripartum morbidity but is associated with the...
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and Cardiomyopathy
Abstract Alzheimer disease (AD) is the most frequent form of dementia causing a significant reduction of quality of life of affected patients. In the brains of AD patients, β-amy...
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense ag...
Novel gastrocnemius muscle characteristics in peripheral artery disease patients associated with impaired functional performance
Lower extremity peripheral artery disease (PAD) significantly affects aging populations and results in functional impairment. Although the clinical importance of finding efficacio...
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
This proposal brings together a unique interdisciplinary team with complementary expertise in high-LET radiobiology, pancreatic cancer research, and high-LET physics. It leverages...
Tissue Damage-Driven Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is responsible for ~10% of total cancer mortality worldwide. SCC prognosis is context-dependent and does not seem to be determined by driver gene som...
T cell invasion of the stem cell compartment during immune-mediated GI damage
Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance in the gastrointestinal (GI) tract and the clinical significance of inflammatory intestinal disor...
Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2D
Abstract Charcot-Marie-Tooth (CMT) disease type 2D is caused by dominant mutations in GARS, encoding glycyl-tRNA synthetase (GlyRS). CMT is a clinically and genetically heterogen...
A Randomized Controlled Trial: Genetic Counseling Patient Preference Intervention via Electronic Health Record Portal vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer
PROJECT SUMMARY Women at elevated risk for breast cancer should complete genetic counseling and may require more frequent screening or additional tests (e.g. breast magnetic reso...
Oxylipin Signaling in Congenital Heart Disease
Project summary Congenital heart defects (CHD) constitute the most common type of congenital defect in humans, however the causes for CHD in most cases are unknown. Lipoxygenase-...
A deubiquitination module controls Treg adaptation to tumor microenvironment
Project Summary: One of the recent advances in cancer treatment is the development of immunotherapy largely through targeting the checkpoint receptors. However, attempts at immun...