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99,167 grants found
Showing 98,021 – 98,040 of 99,167 grants
Leveraging Mechanical Control of Relaxation to Improve Diastolic Function
7. PROJECT SUMMARY/ABSTRACT Impaired diastolic relaxation, an important component of diastolic dysfunction, is present in nearly all patients with heart failure-both with reduce...
Light regulated vascular development in the eye via the Hippo pathway
Light regulated vascular development in the eye via the Hippo pathway Our recent studies show that opsin-mediated light responses function as developmental timing cues for vascul...
Action of Lipolytic Enzymes
PROJECT SUMMARY/ABSTRACT The overall goal of this grant in recent years has been to describe in molecular detail the mechanism of action of physiologically important human forms...
Complexity and the Wound Healing Response
Project Summary The ability to heal is essential for human health. The remarkable wound healing capacity of humans (and indeed of all animals) is a complicated process. Genomic s...
Noninvasive measurement of oxygenation using quantitative susceptibility mapping
PROJECT SUMMARY/ABSTRACT The goal of this research is to develop cardiac quantitative susceptibility mapping (QSM) for non-invasive meas- urement of blood oxygen saturation, towa...
Molecular and Clinical Glycobiology of the Bone Marrow Environment
The life-long production of blood cells requires hematopoietic developmental programs guided by systemic and local signals to convey the dynamic need for these cells. How these si...
TAK1 signaling pathways
Abstract Innate immune signaling pathways are activated in response to exposure to microorganisms, and generally are effective in preventing pathogen invasion through inducing i...
Renal AT2 Receptors in Hypertension
PROJECT SUMMARY/ABSTRACT Hypertension (HT) affects ~48% of the US population. Increased renal sodium (Na+) retention is a major contributor to the development of HT. The renal an...
Precise assembly of retinal circuitry through rejection of inappropriate synaptic partners
During development, retinal neurons make exquisitely precise connections with specific synaptic partners. These synaptic choices impact the computational capacity of retinal circu...
Project 3: Role of Glycosaminoglycans in Hematopoiesis
Project 3 – Project Summary/Abstract Glycosaminoglycans (GAGs) contribute to myriad, and very often opposing, functions such as cellular proliferation as well as apoptosis, self-...
Developing nonmuscle myosin II inhibitors for the treatment of glioblastoma
PROJECT SUMMARY An area of significant unmet need is the treatment of glioblastoma (GBM), an aggressive, fast-growing and lethal brain cancer that represents 15% of all brain tum...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Known modifiable risk fact...
Addressing Social Determinants of Health to Improve Diabetes Prevention Program Outcomes Among Underserved African Americans
PROJECT SUMMARY African Americans (AAs) are disproportionately burdened by diabetes mellitus (DM) with rates twice as high as Whites (13% vs 7.5%), and increased rates of DM-rela...
Estrogen Receptor Signaling in the Expression of Respiratory Motor Plasticity
PROJECT SUMMARY/ABSTRACT The respiratory control system displays a remarkable capacity for neuroplasticity, imparting flexibility of breathing in response to changing physiologic...
Motherhood Biographies and Midlife Women's Health
Abstract Research shows widening health disparities among midlife women since the mid-1980s. However, the mechanisms through which these health gradients operate are not fully kn...
Experience-dependent Cellular Plasticity Mechanisms
Brain activity is essential for the development and plasticity of neurons and circuits, however our understanding of the mechanisms by which activity generates functional circuits...
Kidney PCSK9 in nephrotic syndrome
Summary / Abstract (max 30 lines): Nephrotic syndrome is a major manifestation of human glomerular disease, and patients with this condition develop large amounts of protein in t...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computati...
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
ABSTRACT Despite substantial experimental evidence for the important functional role of myeloid-biased HSC (myHSC) in stress, inflammation and aging, the mechanisms which control...
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome. To reduce this burden, most organisms have evolved sophis...