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99,167 grants found
Showing 961 – 980 of 99,167 grants
Spatial Transcriptomics for Investigating the Interaction between TDP-43 Proteinopathy and Hippocampal Sclerosis in Alzheimer's Disease
PROJECT SUMMARY Alzheimer's Disease (AD) stands as a formidable neurodegenerative affliction impacting millions globally. While substantial headway has been made in decipherin...
Quantitative magnetic resonance imaging of pulmonaryperfusion
Project Summary/Abstract The goal of this project is to establish a pharmacokinetic model for absolute quantification of pulmonary perfusion and microvascular parameters and valida...
A high-throughput assay to measure amyloid-β oligomer formation
Project Summary Toxic oligomers formed by amyloid-beta (Aβ) self-association are of high interest for research into the causes and treatment of Alzheimer's Disease. Studies Aβ...
Obstructive sleep apnea and glycemic dysregulation in adults with type 1 diabetes
Most adults with Type 1 Diabetes (T1D) do not achieve optimal glycemic control, and thus have increased cardiovascular risk. Obstructive sleep apnea (OSA) is a highly common sleep...
Stress and Affective Mechanisms that Relate to Inflammation in Diverse Older Men and Women
Project Summary/Abstract Prolonged, elevated inflammation is detrimental to health, with ties to disease and mortality, making prolonged, elevated inflammation an economic burden a...
Circadian Mechanisms of Glycemic Control and Cardiovascular Risk in Adults with Type 1 Diabetes
Abstract People with type 1 diabetes (T1D) are disproportionately affected by cardiovascular disease (CVD). CVD is a leading cause of death in T1D, contributing to 40% of mortality...
Therapeutic Value of BNC-1 in Addressing Tau Pathology in TBI
PROJECT SUMMARY/ABSTRACT Each year, approximately 200,000 Americans aged 65 and older seek medical care for traumatic brain injuries (TBI), primarily from closed head injuries (CHI...
Helping Patients, Families, and Clinicians Make Shared Decisions about Therapies for Dementia
PROJECT SUMMARY On July 6th, 2023, the FDA approved Lecanemab-IRMB, the first drug with evidence of slowing the rate of cognitive decline through a reduction in amyloid plaques, th...
Development of an amphiphilic PET probe to detect CD206+ microglia/macrophages in Alzheimer's disease
Activated macrophages and microglia are key players in the innate response in the pathogenesis of Alzheimer’s disease (AD). They are closely associated with b-amyloid deposits in b...
Feasibility study for assessing processes and outcomes related to gender affirming care
PROJECT SUMMARY In the United States (U.S.) an estimated 300,000 youth, ages 13-17-years, identify as transgender and, over the past decade, increasing numbers of youth have sought...
Intermingling of circulating B cells and cerebral spinal fluid B cells with advancing age
The broad, long term objective of this project is to elucidate the role that the B cell arm of the immune system plays in the pathophysiology of aging from the stand-point of, and...
Molecular pharmacology of xylazine at adrenoceptors: Relation to necrotic skin lesions associated with chronic intravenous administration
PROJECT SUMMARY/ABSTRACT The α2-adrenergic receptor (α2R) agonist xylazine has been used in veterinary medicine for decades owing to its anesthetic, muscle relaxant, and analgesic...
The mechanisms of cerebral microcirculation response to transcranial stimulation.
Transcranial alternating current stimulation (tACS) is a relatively new non-invasive electrical stimulation technique (tES) where a sinusoidal oscillating low-voltage electric curr...
Negative allosteric modulation of mu opioid receptors to reverse fentanyl overdose
Abstract Fentanyl’s high potency, facile synthesis, abuse liability, and propensity to cause profound respiratory depression via the mu opioid receptor (MOR) have combined to creat...
Novel methods for estimating adult mortality using a survey
ABSTRACT Accurate estimates of adult death rates are critical to good science and health policy. In most high-income countries, adult death rates are directly calculated since civi...
Using a Pragmatic Randomized Rollout Trial to Evaluate Implementation Strategies to Promote Smoking Treatment and Cancer Prevention for Salvation Army Clients
ABSTRACT / PROJECT SUMMARY The prevalence of combustible cigarette tobacco use remains high among socioeconomically disadvantaged Americans despite declines in the broader populati...
Expand human umbilical cord blood hematopoietic stem cells with PPAR-a agonists
Expand human umbilical cord blood hematopoietic stem cells with PPAR-a agonists Abstract Hematopoietic stem cells (HSCs) are defined by their self-renewal potential and ability to...
Elucidate Gene-environmental interactions employed by Pb in promoting ADRD in aging brains
Project Summary Alzheimer's disease and related dementia (AD/ADRD) affect a large percentage of population in the US creating a signficant health care burnden to society. A fe...
AD GxE: In vivo and in vitro modeling of gene x environment interactions
Project Summary Common genetic variants identified through genome-wide association studies have been reproducibly associated with risk for Alzheimer’s disease (AD), but the functio...
Examining the effect of cadmium metal exposure on Alzheimer's disease genetic alleles using herpes viral infected cerebral organoids
PROJECT SUMMARY/ABSTRACT Several genetic variants within immune system genes like APOE, TREM2, BIN1, CR1, etc have been associated with Alzheimer’s disease (AD). There is also evid...